ID FGF20_HUMAN Reviewed; 211 AA. AC Q9NP95; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 10-AUG-2010, entry version 75. DE RecName: Full=Fibroblast growth factor 20; DE Short=FGF-20; GN Name=FGF20; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=20374469; PubMed=10913340; DOI=10.1006/bbrc.2000.3142; RA Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., RA Shiokawa K., Katoh M.; RT "Molecular cloning and characterization of human FGF-20 on chromosome RT 8p21.3-p22."; RL Biochem. Biophys. Res. Commun. 274:337-343(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=20490008; PubMed=11032730; DOI=10.1006/bbrc.2000.3675; RA Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., RA Itoh N.; RT "FGF-20, a novel neurotrophic factor, preferentially expressed in the RT substantia nigra pars compacta of rat brain."; RL Biochem. Biophys. Res. Commun. 277:355-360(2000). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE RP SPECIFICITY. RX PubMed=11306498; RA Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., RA Fernandes E., Rittman B., Shimkets J., LaRochelle W.J., RA Lichenstein H.S.; RT "Identification of a novel human fibroblast growth factor and RT characterization of its role in oncogenesis."; RL Cancer Res. 61:3131-3138(2001). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-116; ALA-175 AND RP ASN-206. RG NIEHS SNPs program; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Neurotrophic factor that regulates central nervous CC development and function. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Predominantly expressed in the cerebellum. CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family. CC -!- WEB RESOURCE: Name=NIEHS-SNPs; CC URL="http://egp.gs.washington.edu/data/fgf20/"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB044277; BAB03633.1; -; mRNA. DR EMBL; AB030648; BAB03530.1; -; mRNA. DR EMBL; AY696296; AAT85804.1; -; Genomic_DNA. DR IPI; IPI00014608; -. DR PIR; JC7353; JC7353. DR RefSeq; NP_062825.1; -. DR UniGene; Hs.199905; -. DR PDB; 3F1R; X-ray; 2.50 A; A/B=1-211. DR PDBsum; 3F1R; -. DR ProteinModelPortal; Q9NP95; -. DR STRING; Q9NP95; -. DR PRIDE; Q9NP95; -. DR Ensembl; ENST00000180166; ENSP00000180166; ENSG00000078579; Homo sapiens. DR GeneID; 26281; -. DR KEGG; hsa:26281; -. DR UCSC; uc003wxc.1; human. DR CTD; 26281; -. DR GeneCards; GC08M016894; -. DR H-InvDB; HIX0034235; -. DR HGNC; HGNC:3677; FGF20. DR MIM; 605558; gene. DR PharmGKB; PA28116; -. DR HOGENOM; HBG715603; -. DR HOVERGEN; HBG007580; -. DR InParanoid; Q9NP95; -. DR OMA; KDILMYS; -. DR OrthoDB; EOG9N5ZG3; -. DR PhylomeDB; Q9NP95; -. DR Reactome; REACT_498; Signaling by Insulin receptor. DR Reactome; REACT_9470; Signaling by FGFR. DR NextBio; 48605; -. DR ArrayExpress; Q9NP95; -. DR Bgee; Q9NP95; -. DR CleanEx; HS_FGF20; -. DR Genevestigator; Q9NP95; -. DR GermOnline; ENSG00000078579; Homo sapiens. DR GO; GO:0005576; C:extracellular region; EXP:Reactome. DR GO; GO:0005625; C:soluble fraction; TAS:ProtInc. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0016049; P:cell growth; IMP:UniProtKB. DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc. DR GO; GO:0008543; P:fibroblast growth factor receptor signaling...; EXP:Reactome. DR GO; GO:0007165; P:signal transduction; TAS:ProtInc. DR InterPro; IPR008996; Cytokine_IL1-like. DR InterPro; IPR002209; GF_heparin-bd. DR InterPro; IPR002348; IL1_HBGF. DR PANTHER; PTHR11486; IL1_HBGF; 1. DR Pfam; PF00167; FGF; 1. DR PRINTS; PR00263; HBGFFGF. DR PRINTS; PR00262; IL1HBGF. DR SMART; SM00442; FGF; 1. DR SUPFAM; SSF50353; Cytok_IL1_like; 1. DR PROSITE; PS00247; HBGF_FGF; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Growth factor; Polymorphism; KW Secreted. FT CHAIN 1 211 Fibroblast growth factor 20. FT /FTId=PRO_0000147616. FT VARIANT 116 116 G -> R (in dbSNP:rs3793405). FT /FTId=VAR_020946. FT VARIANT 175 175 P -> A (in dbSNP:rs10089600). FT /FTId=VAR_020947. FT VARIANT 206 206 D -> N (in dbSNP:rs17550360). FT /FTId=VAR_020948. FT HELIX 56 60 FT STRAND 66 71 FT STRAND 98 101 FT STRAND 108 111 FT HELIX 135 137 FT STRAND 139 145 FT STRAND 148 157 FT STRAND 164 166 FT HELIX 186 188 FT STRAND 190 193 FT HELIX 197 199 FT HELIX 201 203 SQ SEQUENCE 211 AA; 23499 MW; AB04608C16060CC1 CRC64; MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR SKRHQKFTHF LPRPVDPERV PELYKDLLMY T //