ID FGF20_HUMAN Reviewed; 211 AA. AC Q9NP95; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 24-NOV-2009, entry version 69. DE RecName: Full=Fibroblast growth factor 20; DE Short=FGF-20; GN Name=FGF20; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=20374469; PubMed=10913340; DOI=10.1006/bbrc.2000.3142; RA Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., RA Shiokawa K., Katoh M.; RT "Molecular cloning and characterization of human FGF-20 on chromosome RT 8p21.3-p22."; RL Biochem. Biophys. Res. Commun. 274:337-343(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=20490008; PubMed=11032730; DOI=10.1006/bbrc.2000.3675; RA Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., RA Itoh N.; RT "FGF-20, a novel neurotrophic factor, preferentially expressed in the RT substantia nigra pars compacta of rat brain."; RL Biochem. Biophys. Res. Commun. 277:355-360(2000). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE RP SPECIFICITY. RX PubMed=11306498; RA Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., RA Fernandes E., Rittman B., Shimkets J., LaRochelle W.J., RA Lichenstein H.S.; RT "Identification of a novel human fibroblast growth factor and RT characterization of its role in oncogenesis."; RL Cancer Res. 61:3131-3138(2001). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-116; ALA-175 AND RP ASN-206. RG NIEHS SNPs program; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Neurotrophic factor that regulates central nervous CC development and function. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Predominantly expressed in the cerebellum. CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family. CC -!- WEB RESOURCE: Name=NIEHS-SNPs; CC URL="http://egp.gs.washington.edu/data/fgf20/"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB044277; BAB03633.1; -; mRNA. DR EMBL; AB030648; BAB03530.1; -; mRNA. DR EMBL; AY696296; AAT85804.1; -; Genomic_DNA. DR IPI; IPI00014608; -. DR PIR; JC7353; JC7353. DR RefSeq; NP_062825.1; -. DR UniGene; Hs.199905; -. DR PDB; 3F1R; X-ray; 2.50 A; A/B=1-211. DR PDBsum; 3F1R; -. DR SMR; Q9NP95; 57-208. DR STRING; Q9NP95; -. DR PRIDE; Q9NP95; -. DR Ensembl; ENST00000180166; ENSP00000180166; ENSG00000078579; Homo sapiens. DR GeneID; 26281; -. DR KEGG; hsa:26281; -. DR UCSC; uc003wxc.1; human. DR CTD; 26281; -. DR GeneCards; GC08M016894; -. DR H-InvDB; HIX0034235; -. DR HGNC; HGNC:3677; FGF20. DR MIM; 605558; gene. DR PharmGKB; PA28116; -. DR HOGENOM; Q9NP95; -. DR HOVERGEN; Q9NP95; -. DR OMA; KDILMYS; -. DR OrthoDB; EOG9N5ZG3; -. DR Reactome; REACT_9470; Signaling by FGFR. DR NextBio; 48605; -. DR ArrayExpress; Q9NP95; -. DR Bgee; Q9NP95; -. DR CleanEx; HS_FGF20; -. DR Genevestigator; Q9NP95; -. DR GermOnline; ENSG00000078579; Homo sapiens. DR GO; GO:0005576; C:extracellular region; EXP:Reactome. DR GO; GO:0005625; C:soluble fraction; TAS:ProtInc. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0016049; P:cell growth; IMP:UniProtKB. DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc. DR GO; GO:0008543; P:fibroblast growth factor receptor signaling...; EXP:Reactome. DR InterPro; IPR008996; Cytokine_IL1-like. DR InterPro; IPR002209; GF_heparin_bd. DR InterPro; IPR002348; IL1_HBGF. DR PANTHER; PTHR11486; IL1_HBGF; 1. DR Pfam; PF00167; FGF; 1. DR PRINTS; PR00263; HBGFFGF. DR PRINTS; PR00262; IL1HBGF. DR SMART; SM00442; FGF; 1. DR PROSITE; PS00247; HBGF_FGF; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Growth factor; Polymorphism; KW Secreted. FT CHAIN 1 211 Fibroblast growth factor 20. FT /FTId=PRO_0000147616. FT VARIANT 116 116 G -> R (in dbSNP:rs3793405). FT /FTId=VAR_020946. FT VARIANT 175 175 P -> A (in dbSNP:rs10089600). FT /FTId=VAR_020947. FT VARIANT 206 206 D -> N (in dbSNP:rs17550360). FT /FTId=VAR_020948. SQ SEQUENCE 211 AA; 23499 MW; AB04608C16060CC1 CRC64; MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR SKRHQKFTHF LPRPVDPERV PELYKDLLMY T //