ID FGF20_HUMAN STANDARD; PRT; 211 AA. AC Q9NP95; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 01-FEB-2005 (Rel. 46, Last annotation update) DE Fibroblast growth factor-20 (FGF-20). GN Name=FGF20; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=20374469; PubMed=10913340; DOI=10.1006/bbrc.2000.3142; RA Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., RA Shiokawa K., Katoh M.; RT "Molecular cloning and characterization of human FGF-20 on chromosome RT 8p21.3-p22."; RL Biochem. Biophys. Res. Commun. 274:337-343(2000). RN [2] RP NUCLEOTIDE SEQUENCE. RA Itoh N.; RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE, AND VARIANTS ARG-116; ALA-175 AND ASN-206. RA Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., RA Nguyen C.P., Nguyen D.A., Poel C.L., Chambers S.W., Schackwitz W.S., RA Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; RT "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department RT of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Secreted (Potential). CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB044277; BAB03633.1; -. DR EMBL; AB030648; BAB03530.1; -. DR EMBL; AY696296; AAT85804.1; -. DR PIR; JC7353; JC7353. DR HSSP; P31371; 1IHK. DR Ensembl; ENSG00000078579; Homo sapiens. DR Genew; HGNC:3677; FGF20. DR MIM; 605558; -. DR GO; GO:0005576; C:extracellular region; TAS. DR GO; GO:0005625; C:soluble fraction; TAS. DR GO; GO:0007267; P:cell-cell signaling; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR008996; Cytok_IL1_like. DR InterPro; IPR002209; HB/F_growthfact. DR InterPro; IPR002348; IL1_HBGF. DR Pfam; PF00167; FGF; 1. DR PRINTS; PR00263; HBGFFGF. DR PRINTS; PR00262; IL1HBGF. DR ProDom; PD000831; IL1_HBGF; 1. DR SMART; SM00442; FGF; 1. DR PROSITE; PS00247; HBGF_FGF; 1. KW Growth factor; Polymorphism. FT VARIANT 116 116 G -> R. FT /FTId=VAR_020946. FT VARIANT 175 175 P -> A. FT /FTId=VAR_020947. FT VARIANT 206 206 D -> N. FT /FTId=VAR_020948. SQ SEQUENCE 211 AA; 23499 MW; AB04608C16060CC1 CRC64; MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR SKRHQKFTHF LPRPVDPERV PELYKDLLMY T //