ID FGF20_HUMAN Reviewed; 211 AA. AC Q9NP95; B2RPH5; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 01-OCT-2014, entry version 111. DE RecName: Full=Fibroblast growth factor 20; DE Short=FGF-20; GN Name=FGF20; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=10913340; DOI=10.1006/bbrc.2000.3142; RA Kirikoshi H., Sagara N., Saitoh T., Tanaka K., Sekihara H., RA Shiokawa K., Katoh M.; RT "Molecular cloning and characterization of human FGF-20 on chromosome RT 8p21.3-p22."; RL Biochem. Biophys. Res. Commun. 274:337-343(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX PubMed=11032730; DOI=10.1006/bbrc.2000.3675; RA Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., RA Itoh N.; RT "FGF-20, a novel neurotrophic factor, preferentially expressed in the RT substantia nigra pars compacta of rat brain."; RL Biochem. Biophys. Res. Commun. 277:355-360(2000). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE RP SPECIFICITY. RX PubMed=11306498; RA Jeffers M., Shimkets R., Prayaga S., Boldog F., Yang M., Burgess C., RA Fernandes E., Rittman B., Shimkets J., LaRochelle W.J., RA Lichenstein H.S.; RT "Identification of a novel human fibroblast growth factor and RT characterization of its role in oncogenesis."; RL Cancer Res. 61:3131-3138(2001). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-116; ALA-175 AND RP ASN-206. RG NIEHS SNPs program; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP INTERACTION WITH FGFR2 AND FGFR4, AND FUNCTION IN STIMULATION OF CELL RP PROLIFERATION. RX PubMed=16597617; DOI=10.1074/jbc.M601252200; RA Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., RA Ornitz D.M.; RT "Receptor specificity of the fibroblast growth factor family. The RT complete mammalian FGF family."; RL J. Biol. Chem. 281:15694-15700(2006). RN [8] RP REVIEW. RX PubMed=20094046; DOI=10.1038/nrc2780; RA Turner N., Grose R.; RT "Fibroblast growth factor signalling: from development to cancer."; RL Nat. Rev. Cancer 10:116-129(2010). RN [9] RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), SUBUNIT, AND HEPARIN-BINDING. RX PubMed=19564416; DOI=10.1128/MCB.01780-08; RA Kalinina J., Byron S.A., Makarenkova H.P., Olsen S.K., RA Eliseenkova A.V., Larochelle W.J., Dhanabal M., Blais S., Ornitz D.M., RA Day L.A., Neubert T.A., Pollock P.M., Mohammadi M.; RT "Homodimerization controls the fibroblast growth factor 9 subfamily's RT receptor binding and heparan sulfate-dependent diffusion in the RT extracellular matrix."; RL Mol. Cell. Biol. 29:4663-4678(2009). CC -!- FUNCTION: Neurotrophic factor that regulates central nervous CC development and function. {ECO:0000269|PubMed:16597617}. CC -!- SUBUNIT: Homodimer. Interacts with FGFR2 and FGFR4. Affinity CC between fibroblast growth factors (FGFs) and their receptors is CC increased by heparan sulfate glycosaminoglycans that function as CC coreceptors. {ECO:0000269|PubMed:16597617, CC ECO:0000269|PubMed:19564416}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11306498}. CC -!- TISSUE SPECIFICITY: Predominantly expressed in the cerebellum. CC {ECO:0000269|PubMed:11306498}. CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family. CC {ECO:0000305}. CC -!- WEB RESOURCE: Name=NIEHS-SNPs; CC URL="http://egp.gs.washington.edu/data/fgf20/"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB044277; BAB03633.1; -; mRNA. DR EMBL; AB030648; BAB03530.1; -; mRNA. DR EMBL; AY696296; AAT85804.1; -; Genomic_DNA. DR EMBL; CH471080; EAW63828.1; -; Genomic_DNA. DR EMBL; BC137446; AAI37447.1; -; mRNA. DR EMBL; BC137447; AAI37448.1; -; mRNA. DR CCDS; CCDS5998.1; -. DR PIR; JC7353; JC7353. DR RefSeq; NP_062825.1; NM_019851.2. DR UniGene; Hs.199905; -. DR PDB; 3F1R; X-ray; 2.50 A; A/B=1-211. DR PDBsum; 3F1R; -. DR ProteinModelPortal; Q9NP95; -. DR SMR; Q9NP95; 52-208. DR STRING; 9606.ENSP00000180166; -. DR PhosphoSite; Q9NP95; -. DR DMDM; 13626702; -. DR PaxDb; Q9NP95; -. DR PRIDE; Q9NP95; -. DR Ensembl; ENST00000180166; ENSP00000180166; ENSG00000078579. DR GeneID; 26281; -. DR KEGG; hsa:26281; -. DR UCSC; uc003wxc.1; human. DR CTD; 26281; -. DR GeneCards; GC08M016894; -. DR HGNC; HGNC:3677; FGF20. DR MIM; 605558; gene. DR neXtProt; NX_Q9NP95; -. DR PharmGKB; PA28116; -. DR eggNOG; NOG269410; -. DR HOGENOM; HOG000236341; -. DR HOVERGEN; HBG007580; -. DR InParanoid; Q9NP95; -. DR KO; K04358; -. DR OMA; YKDILMY; -. DR OrthoDB; EOG7992S1; -. DR PhylomeDB; Q9NP95; -. DR TreeFam; TF317805; -. DR Reactome; REACT_111184; Negative regulation of FGFR signaling. DR Reactome; REACT_120863; Activated point mutants of FGFR2. DR Reactome; REACT_121153; Signaling by activated point mutants of FGFR1. DR Reactome; REACT_121249; Signaling by FGFR3 mutants. DR Reactome; REACT_121337; Signaling by activated point mutants of FGFR3. DR Reactome; REACT_121398; Signaling by FGFR mutants. DR Reactome; REACT_147727; Constitutive PI3K/AKT Signaling in Cancer. DR Reactome; REACT_21247; FRS2-mediated cascade. DR Reactome; REACT_21270; PI-3K cascade. DR Reactome; REACT_21310; Phospholipase C-mediated cascade. DR Reactome; REACT_21374; SHC-mediated cascade. DR Reactome; REACT_75829; PIP3 activates AKT signaling. DR Reactome; REACT_9413; FGFR2c ligand binding and activation. DR Reactome; REACT_9452; FGFR4 ligand binding and activation. DR Reactome; REACT_9508; FGFR3b ligand binding and activation. DR Reactome; REACT_9510; FGFR3c ligand binding and activation. DR Reactome; REACT_9515; FGFR1c ligand binding and activation. DR Reactome; REACT_976; PI3K Cascade. DR EvolutionaryTrace; Q9NP95; -. DR GenomeRNAi; 26281; -. DR NextBio; 48605; -. DR PRO; PR:Q9NP95; -. DR Bgee; Q9NP95; -. DR CleanEx; HS_FGF20; -. DR Genevestigator; Q9NP95; -. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc. DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome. DR GO; GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome. DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome. DR GO; GO:0045087; P:innate immune response; TAS:Reactome. DR GO; GO:0060113; P:inner ear receptor cell differentiation; IEA:Ensembl. DR GO; GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome. DR GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome. DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome. DR GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0060043; P:regulation of cardiac muscle cell proliferation; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; TAS:ProtInc. DR InterPro; IPR008996; Cytokine_IL1-like. DR InterPro; IPR028291; FGF20. DR InterPro; IPR002209; Fibroblast_GF_fam. DR InterPro; IPR028142; IL-1_fam/FGF_fam. DR PANTHER; PTHR11486; PTHR11486; 1. DR PANTHER; PTHR11486:SF72; PTHR11486:SF72; 1. DR Pfam; PF00167; FGF; 1. DR PRINTS; PR00263; HBGFFGF. DR PRINTS; PR00262; IL1HBGF. DR SMART; SM00442; FGF; 1. DR SUPFAM; SSF50353; SSF50353; 1. DR PROSITE; PS00247; HBGF_FGF; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Growth factor; Polymorphism; KW Reference proteome; Secreted. FT CHAIN 1 211 Fibroblast growth factor 20. FT /FTId=PRO_0000147616. FT VARIANT 116 116 G -> R (in dbSNP:rs3793405). FT {ECO:0000269|Ref.4}. FT /FTId=VAR_020946. FT VARIANT 175 175 P -> A (in dbSNP:rs10089600). FT {ECO:0000269|Ref.4}. FT /FTId=VAR_020947. FT VARIANT 206 206 D -> N (in dbSNP:rs17550360). FT {ECO:0000269|Ref.4}. FT /FTId=VAR_020948. FT HELIX 56 64 FT STRAND 66 71 FT TURN 72 74 FT STRAND 75 79 FT STRAND 85 89 FT STRAND 94 104 FT STRAND 107 112 FT TURN 113 115 FT STRAND 118 121 FT STRAND 127 132 FT HELIX 135 137 FT STRAND 139 145 FT STRAND 148 157 FT TURN 159 161 FT STRAND 164 166 FT STRAND 173 175 FT HELIX 178 180 FT HELIX 186 188 FT STRAND 190 193 FT HELIX 197 199 FT HELIX 201 203 SQ SEQUENCE 211 AA; 23499 MW; AB04608C16060CC1 CRC64; MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR SKRHQKFTHF LPRPVDPERV PELYKDLLMY T //