ID   VCX3_HUMAN              Reviewed;         186 AA.
AC   Q9NNX9; Q9P0H4;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   02-DEC-2020, entry version 116.
DE   RecName: Full=Variable charge X-linked protein 3;
DE   AltName: Full=Variable charge protein on X with eight repeats;
DE            Short=VCX-8r;
DE   AltName: Full=Variably charged protein X-A;
DE            Short=VCX-A;
GN   Name=VCX3A; Synonyms=VCX3, VCX8R, VCXA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=10903929; DOI=10.1086/303047;
RA   Fukami M., Kirsch S., Schiller S., Richter A., Benes V., Franco B.,
RA   Muroya K., Rao E., Merker S., Niesler B., Ballabio A., Ansorge W.,
RA   Ogata T., Rappold G.A.;
RT   "A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-
RT   linked nonspecific mental retardation.";
RL   Am. J. Hum. Genet. 67:563-573(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10607842; DOI=10.1093/hmg/9.2.311;
RA   Lahn B.T., Page D.C.;
RT   "A human sex-chromosomal gene family expressed in male germ cells and
RT   encoding variably charged proteins.";
RL   Hum. Mol. Genet. 9:311-319(2000).
CC   -!- FUNCTION: May mediate a process in spermatogenesis or may play a role
CC       in sex ratio distortion.
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in testis.
CC   -!- SIMILARITY: Belongs to the VCX/VCY family. {ECO:0000305}.
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DR   EMBL; AJ243947; CAB56197.1; -; Genomic_DNA.
DR   EMBL; AF167078; AAG41764.1; -; mRNA.
DR   EMBL; AF159128; AAF28173.1; -; mRNA.
DR   CCDS; CCDS35199.1; -.
DR   RefSeq; NP_057463.2; NM_016379.3.
DR   SMR; Q9NNX9; -.
DR   STRING; 9606.ENSP00000370479; -.
DR   iPTMnet; Q9NNX9; -.
DR   PhosphoSitePlus; Q9NNX9; -.
DR   BioMuta; VCX3A; -.
DR   PaxDb; Q9NNX9; -.
DR   PeptideAtlas; Q9NNX9; -.
DR   PRIDE; Q9NNX9; -.
DR   ProteomicsDB; 81877; -.
DR   Antibodypedia; 23556; 95 antibodies.
DR   DNASU; 51481; -.
DR   Ensembl; ENST00000381089; ENSP00000370479; ENSG00000169059.
DR   GeneID; 51481; -.
DR   KEGG; hsa:51481; -.
DR   UCSC; uc004crs.3; human.
DR   CTD; 51481; -.
DR   DisGeNET; 51481; -.
DR   EuPathDB; HostDB:ENSG00000169059.12; -.
DR   GeneCards; VCX3A; -.
DR   HGNC; HGNC:18159; VCX3A.
DR   HPA; ENSG00000169059; Tissue enriched (testis).
DR   MIM; 300533; gene.
DR   neXtProt; NX_Q9NNX9; -.
DR   OpenTargets; ENSG00000169059; -.
DR   PharmGKB; PA134936169; -.
DR   eggNOG; KOG3216; Eukaryota.
DR   GeneTree; ENSGT00440000034745; -.
DR   InParanoid; Q9NNX9; -.
DR   PathwayCommons; Q9NNX9; -.
DR   BioGRID-ORCS; 51481; 1 hit in 97 CRISPR screens.
DR   GenomeRNAi; 51481; -.
DR   Pharos; Q9NNX9; Tbio.
DR   PRO; PR:Q9NNX9; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q9NNX9; protein.
DR   Bgee; ENSG00000169059; Expressed in testis and 61 other tissues.
DR   ExpressionAtlas; Q9NNX9; baseline.
DR   Genevisible; Q9NNX9; HS.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0007420; P:brain development; IMP:UniProtKB.
DR   InterPro; IPR026653; VCX/VCY1.
DR   Pfam; PF15231; VCX_VCY; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat.
FT   CHAIN           1..186
FT                   /note="Variable charge X-linked protein 3"
FT                   /id="PRO_0000184661"
FT   REPEAT          104..113
FT                   /note="1"
FT   REPEAT          114..123
FT                   /note="2"
FT   REPEAT          124..133
FT                   /note="3"
FT   REPEAT          134..143
FT                   /note="4"
FT   REPEAT          144..153
FT                   /note="5"
FT   REPEAT          154..163
FT                   /note="6"
FT   REPEAT          164..173
FT                   /note="7"
FT   REPEAT          174..183
FT                   /note="8"
FT   REGION          104..183
FT                   /note="8 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-P"
FT   COMPBIAS        82..186
FT                   /note="Glu-rich"
FT   CONFLICT        108
FT                   /note="S -> A (in Ref. 2; AAF28173)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   186 AA;  20020 MW;  8C9C5F66FB97EE9A CRC64;
     MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR GKKGAATKMA
     AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQESEL EEPLSQESEV
     EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEM
     EELPSV
//