ID Q9MD82_MOUSE PRELIMINARY; PRT; 607 AA. AC Q9MD82; DT 01-OCT-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2000, sequence version 1. DT 13-JUN-2006, entry version 35. DE NADH dehydrogenase subunit 5 (EC 1.6.5.3) (10 days neonate medulla DE oblongata cDNA, RIKEN full-length enriched library, clone:B830039K22 DE product:unclassifiable, full insert sequence). GN Name=ND5; OS Mus musculus (Mouse). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=SAMP8, SAMP1, and SAMR1; TISSUE=Liver; RA Mori M., Higuchi K., Tanaka M.; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RA Moreno-Loshuertos R., Acin-Perez R., Fernandez-Silva P., Movilla N., RA Perez-Martos A., Rodriguez de Cordoba S., Gallardo M.E., RA Enriquez J.A.; RT "Differences in ROS production provide a molecular explanation for the RT phenotypes associated to common mouse mitochondrial DNA variants."; RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=CBA/J; RA Moreno-Loshuertos R., Acin-Perez R., Fernandez-Silva P., Movilla N., RA Perez-Martos A., Rodriguez de Cordoba S., Gallardo M.E., RA Enriquez J.A.; RT "Differences in ROS production provide a molecular explanation for the RT phenotypes associated to common mouse mitochondrial DNA variants."; RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RX MEDLINE=99279253; PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schonbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group, and Genome Science Group RG (Genome Network Core Team) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RX MEDLINE=22354683; PubMed=12466851; DOI=10.1038/nature01266; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RX MEDLINE=21085660; PubMed=11217851; DOI=10.1038/35055500; RA Kawai J., Shinagawa A., Shibata K., Yoshino M., Itoh M., Ishii Y., RA Arakawa T., Hara A., Fukunishi Y., Konno H., Adachi J., Fukuda S., RA Aizawa K., Izawa M., Nishi K., Kiyosawa H., Kondo S., Yamanaka I., RA Saito T., Okazaki Y., Gojobori T., Bono H., Kasukawa T., Saito R., RA Kadota K., Matsuda H.A., Ashburner M., Batalov S., Casavant T., RA Fleischmann W., Gaasterland T., Gissi C., King B., Kochiwa H., RA Kuehl P., Lewis S., Matsuo Y., Nikaido I., Pesole G., Quackenbush J., RA Schriml L.M., Staubli F., Suzuki R., Tomita M., Wagner L., Washio T., RA Sakai K., Okido T., Furuno M., Aono H., Baldarelli R., Barsh G., RA Blake J., Boffelli D., Bojunga N., Carninci P., de Bonaldo M.F., RA Brownstein M.J., Bult C., Fletcher C., Fujita M., Gariboldi M., RA Gustincich S., Hill D., Hofmann M., Hume D.A., Kamiya M., Lee N.H., RA Lyons P., Marchionni L., Mashima J., Mazzarelli J., Mombaerts P., RA Nordone P., Ring B., Ringwald M., Rodriguez I., Sakamoto N., RA Sasaki H., Sato K., Schoenbach C., Seya T., Shibata Y., Storch K.-F., RA Suzuki H., Toyo-oka K., Wang K.H., Weitz C., Whittaker C., Wilming L., RA Wynshaw-Boris A., Yoshida K., Hasegawa Y., Kawaji H., Kohtsuki S., RA Hayashizaki Y.; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [9] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RX MEDLINE=20499374; PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [10] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RX MEDLINE=20530913; PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system-384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [11] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NON/Lt, NOD/LtJ, ALS/Lt, and ALR/Lt; RA Mathews C.E., Leiter E.H., Spirina O., Bykhovskaya Y., RA Fischel-Ghodsian N.; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. RN [13] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NON/Lt, NOD/LtJ, ALS/Lt, and ALR/Lt; RA Gusdon A.M., Spirina O., Bykhovskaya Y., Fischel-Ghodsia N., RA Libert T., Trucco M., Mathews C.E.; RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases. RN [14] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, Balb/cJ, and C3H/An; TISSUE=Platelets, and RC Connective; RX MEDLINE=22836051; PubMed=12954771; DOI=10.1093/nar/gkg739; RA Bayona-Bafaluy M.P., Acin-Perez R., Mullikin J.C., Park J.S., RA Moreno-Loshuertos R., Hu P., Perez-Martos A., Fernandez-Silva P., RA Bai Y., Enriquez J.A.; RT "Revisiting the mouse mitochondrial DNA sequence."; RL Nucleic Acids Res. 31:5349-5355(2003). RN [15] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Balb/cJ, and C3H/An; TISSUE=Platelets, and Connective; RX MEDLINE=22442040; PubMed=12554686; DOI=10.1093/hmg/ddg021; RA Acin-Perez R., Bayona-Bafaluy M., Bueno M., Machicado C., RA Fernandez-Silva P., Perez-Martos A., Montoya J., Lopez-Perez M.J., RA Sancho J., Enriquez J.A.; RT "An intragenic supressor in the cytochrome c oxidase I gene of mouse RT mitochondrial DNA."; RL Hum. Mol. Genet. 12:329-339(2003). RN [16] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C3H/He; RA Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol. CC -!- SUBCELLULAR LOCATION: Mitochondrion; mitochondrial inner membrane; CC multi-pass membrane protein (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB042809; BAA95805.1; -; Genomic_DNA. DR EMBL; AY999076; AAX83022.1; -; Genomic_DNA. DR EMBL; AY466499; AAR21205.1; -; Genomic_DNA. DR EMBL; AK140457; BAE24397.1; -; mRNA. DR EMBL; AY533108; AAS01475.1; -; Genomic_DNA. DR EMBL; AY533107; AAS01462.1; -; Genomic_DNA. DR EMBL; AY533106; AAS01449.1; -; Genomic_DNA. DR EMBL; AY533105; AAS01436.1; -; Genomic_DNA. DR EMBL; AY172335; AAN85132.1; -; Genomic_DNA. DR EMBL; AJ512208; CAD54442.1; -; Genomic_DNA. DR EMBL; AJ489607; CAD33917.1; -; Genomic_DNA. DR EMBL; AB049357; BAB13811.1; -; Genomic_DNA. DR EMBL; AB042524; BAA95650.1; -; Genomic_DNA. DR EMBL; AB042523; BAA95663.1; -; Genomic_DNA. DR Ensembl; ENSMUSG00000064367; Mus musculus. DR GO; GO:0016021; C:integral to membrane; IEA. DR GO; GO:0016020; C:membrane; IEA. DR GO; GO:0005739; C:mitochondrion; IEA. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA. DR GO; GO:0016491; F:oxidoreductase activity; IEA. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA. DR InterPro; IPR010934; NADH_DH_S5_C. DR InterPro; IPR003945; NADHpl_oxred5. DR InterPro; IPR003916; NADHub_oxred5. DR InterPro; IPR001750; Oxidored_q1. DR InterPro; IPR001516; Oxidored_q1_N. DR Pfam; PF06455; NADH5_C; 1. DR Pfam; PF00361; Oxidored_q1; 1. DR Pfam; PF00662; Oxidored_q1_N; 1. DR PRINTS; PR01434; NADHDHGNASE5. DR TIGRFAMs; TIGR01974; NDH_I_L; 1. KW Inner membrane; Membrane; Mitochondrion; NAD; Oxidoreductase; KW Transmembrane; Ubiquinone. SQ SEQUENCE 607 AA; 68475 MW; 31C10862CDC78B10 CRC64; MNIFTTSILL IFILLLSPIL ISMSNLIKHI NFPLYTTTSI KFSFIISLLP LLMFFHNNME YMITTWHWVT MNSMELKMSF KTDFFSILFT SVALFVTWSI MQFSSWYMHS DPNINRFIKY LTLFLITMLI LTSANNMFQL FIGWEGVGIM SFLLIGWWYG RTDANTAALQ AILYNRIGDI GFILAMVWFS LNMNSWELQQ IMFSNNNDNL IPLMGLLIAA TGKSAQFGLH PWLPSAMEGP TPVSALLHSS TMVVAGIFLL VRFHPLTTNN NFILTTMLCL GALTTLFTAI CALTQNDIKK IIAFSTSSQL GLMMVTLGMN QPHLAFLHIC THAFFKAMLF MCSGSIIHSL ADEQDIRKMG NITKIMPFTS SCLVIGSLAL TGMPFLTGFY SKDLIIEAIN TCNTNAWALL ITLIATSMTA MYSMRIIYFV TMTKPRFPPL ISINENDPDL MNPIKRLAFG SIFAGFVISY NIPPTSIPVL TMPWFLKTTA LIISVLGFLI ALELNNLTMK LSMNKANPYS SFSTLLGFFP SIIHRITPMK SLNLSLKTSL TLLDLIWLEK TIPKSTSTLH TNMTTLTTNQ KGLIKLYFMS FLINIILIII LYSINLE //