ID Q9MD82_MOUSE Unreviewed; 607 AA. AC Q9MD82; DT 01-OCT-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2000, sequence version 1. DT 29-SEP-2021, entry version 178. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5 {ECO:0000256|RuleBase:RU003404}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003404}; GN Name=mt-Nd5 {ECO:0000313|MGI:MGI:102496}; GN Synonyms=mt-ND5 {ECO:0000313|EMBL:QPG85865.1}, mt-Nd6 GN {ECO:0000313|MGI:MGI:102496}, ND5 {ECO:0000313|EMBL:BAA95805.1}, Nd5 GN {ECO:0000313|EMBL:ADR03166.1}; OS Mus musculus (Mouse). OG Mitochondrion {ECO:0000313|EMBL:BAA95805.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAA95805.1}; RN [1] {ECO:0000313|EMBL:BAE24397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24397.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24397.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAE24397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24397.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24397.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAE24397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24397.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24397.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAA95805.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SAMP1 {ECO:0000313|EMBL:BAA95650.1}, SAMP8 RC {ECO:0000313|EMBL:BAA95805.1}, and SAMR1 RC {ECO:0000313|EMBL:BAA95663.1}; RC TISSUE=Liver {ECO:0000313|EMBL:BAA95805.1}; RA Mori M., Higuchi K., Tanaka M.; RT "Unique transitional nucleotide mutations in the mitochondrial DNA of RT Senescence-accelerated Mouse (SAM) strains."; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:BAB13811.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C3H/He {ECO:0000313|EMBL:BAB13811.1}; RA Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.; RT "Unique mutations in mitochondrial DNA of Senescence-Accelerated Mouse RT (SAM) strains."; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:BAE24397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24397.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24397.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [7] {ECO:0000313|EMBL:BAE24397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24397.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24397.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [8] {ECO:0000313|EMBL:CAD33917.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Balb/cJ {ECO:0000313|EMBL:CAD54442.1}, and C3H/An RC {ECO:0000313|EMBL:CAD33917.1}; RC TISSUE=Connective {ECO:0000313|EMBL:CAD33917.1}, and Platelets RC {ECO:0000313|EMBL:CAD54442.1}; RX PubMed=12554686; DOI=10.1093/hmg/ddg021; RA Acin-Perez R., Bayona-Bafaluy M., Bueno M., Machicado C., RA Fernandez-Silva P., Perez-Martos A., Montoya J., Lopez-Perez M.J., RA Sancho J., Enriquez J.A.; RT "An intragenic suppressor in the cytochrome c oxidase I gene of mouse RT mitochondrial DNA."; RL Hum. Mol. Genet. 12:329-339(2003). RN [9] {ECO:0000313|EMBL:CAD33917.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Balb/cJ {ECO:0000313|EMBL:CAD54442.1}, and C3H/An RC {ECO:0000313|EMBL:CAD33917.1}; RC TISSUE=Connective {ECO:0000313|EMBL:CAD33917.1}, and Platelets RC {ECO:0000313|EMBL:CAD54442.1}; RX PubMed=12954771; DOI=10.1093/nar/gkg739; RA Bayona-Bafaluy M.P., Acin-Perez R., Mullikin J.C., Park J.S., RA Moreno-Loshuertos R., Hu P., Perez-Martos A., Fernandez-Silva P., Bai Y., RA Enriquez J.A.; RT "Revisiting the mouse mitochondrial DNA sequence."; RL Nucleic Acids Res. 31:5349-5355(2003). RN [10] {ECO:0000313|EMBL:AAS01436.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ALR/Lt {ECO:0000313|EMBL:AAS01436.1}, ALS/Lt RC {ECO:0000313|EMBL:AAS01449.1}, NOD/LtJ {ECO:0000313|EMBL:AAS01462.1}, RC and NON/Lt {ECO:0000313|EMBL:AAS01475.1}; RA Gusdon A.M., Spirina O., Bykhovskaya Y., Fischel-Ghodsia N., Libert T., RA Trucco M., Mathews C.E.; RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:AAS01436.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ALR/Lt {ECO:0000313|EMBL:AAS01436.1}, ALS/Lt RC {ECO:0000313|EMBL:AAS01449.1}, NOD/LtJ {ECO:0000313|EMBL:AAS01462.1}, RC and NON/Lt {ECO:0000313|EMBL:AAS01475.1}; RA Mathews C.E., Leiter E.H., Spirina O., Bykhovskaya Y., Fischel-Ghodsian N.; RT "The ALR/Lt Mouse: Contribution of the Mitochondrial Genome in Resistance RT Against both Chemically-Induced and Autoimmune Diabetes."; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:BAE24397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24397.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24397.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:BAE24397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24397.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24397.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [14] {ECO:0000313|EMBL:BAE24397.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE24397.1}; RC TISSUE=Medulla oblongata {ECO:0000313|EMBL:BAE24397.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [15] {ECO:0000313|EMBL:AAR21205.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CBA/J {ECO:0000313|EMBL:AAR21205.1}; RX PubMed=17013393; DOI=10.1038/ng1897; RA Moreno-Loshuertos R., Acin-Perez R., Fernandez-Silva P., Movilla N., RA Perez-Martos A., de Cordoba S.R., Gallardo M.E., Enriquez J.A.; RT "Differences in reactive oxygen species production explain the phenotypes RT associated with common mouse mitochondrial DNA variants."; RL Nat. Genet. 38:1261-1268(2006). RN [16] {ECO:0000313|EMBL:ABK79103.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=129S1/SvImJ {ECO:0000313|EMBL:ABK79103.1}, A/J RC {ECO:0000313|EMBL:ABK79116.1}, AKR/J {ECO:0000313|EMBL:ABK79129.1}, RC BALB/cByJ {ECO:0000313|EMBL:ABK79142.1}, BTBR T+ tf/J RC {ECO:0000313|EMBL:ABK79155.1}, C3H/HeJ {ECO:0000313|EMBL:ABK79168.1}, RC C57BL/6J {ECO:0000313|EMBL:ABK79181.1}, DBA/2J RC {ECO:0000313|EMBL:ABK79194.1}, FVB/NJ {ECO:0000313|EMBL:ABK79207.1}, RC KK/HlJ {ECO:0000313|EMBL:ABK79220.1}, NOD/LtJ RC {ECO:0000313|EMBL:ABK79233.1}, and NZW/LacJ RC {ECO:0000313|EMBL:ABK79246.1}; RX PubMed=17284675; DOI=10.1101/gr.5941007; RA Goios A., Pereira L., Bogue M., Macaulay V., Amorim A.; RT "mtDNA phylogeny and evolution of laboratory mouse strains."; RL Genome Res. 17:293-298(2007). RN [17] {ECO:0000313|EMBL:ACA01533.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MRL/MpJ {ECO:0000313|EMBL:ACA01533.1}; RC TISSUE=Heart {ECO:0000313|EMBL:ACA01533.1}; RX PubMed=18761428; DOI=10.1016/j.mito.2008.07.007; RA Sachadyn P., Zhang X.M., Clark L.D., Naviaux R.K., Heber-Katz E.; RT "Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse."; RL Mitochondrion 8:358-366(2008). RN [18] {ECO:0000313|EMBL:ADZ23173.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6NCrl {ECO:0000313|EMBL:ADZ23173.1}; RX PubMed=18232733; DOI=10.1371/journal.pbio.0060010; RA Stewart J.B., Freyer C., Elson J.L., Wredenberg A., Cansu Z., RA Trifunovic A., Larsson N.G.; RT "Strong purifying selection in transmission of mammalian mitochondrial RT DNA."; RL PLoS Biol. 6:E10-E10(2008). RN [19] {ECO:0000313|EMBL:ABX79712.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C3H/An {ECO:0000313|EMBL:ABX79738.1}, and C57BL/6 RC {ECO:0000313|EMBL:ABX79712.1}; RX PubMed=18388260; DOI=10.1126/science.1156906; RA Ishikawa K., Takenaga K., Akimoto M., Koshikawa N., Yamaguchi A., RA Imanishi H., Nakada K., Honma Y., Hayashi J.; RT "ROS-generating mitochondrial DNA mutations can regulate tumor cell RT metastasis."; RL Science 320:661-664(2008). RN [20] {ECO:0000313|EMBL:ACN91105.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C3H/An {ECO:0000313|EMBL:ACN91105.1}; RA Ishikawa K., Toyama-Sorimachi N., Nakada K., Morimoto M., Niikura M., RA Takenaga K., Yonekawa H., Hayashi J.-I.; RT "Innate immunity in the host mice targets cells with polymorphic mutations RT in mtDNA."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [22] {ECO:0000313|EMBL:ADR03166.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN/aW {ECO:0000313|EMBL:ADR03166.1}; RA Gajewska M., Unrug-Bielawska K., Strzalkowska A.; RT "Mitochondrion complete sequence of BN/aW mouse strain."; RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:AEN03379.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FVB/NJ {ECO:0000313|EMBL:AEN03379.1}; RX PubMed=21858071; DOI=10.1371/journal.pone.0023327; RA Seoane M., Mosquera-Miguel A., Gonzalez T., Fraga M., Salas A., RA Costoya J.A.; RT "The Mitochondrial Genome Is a 'Genetic Sanctuary' during the Oncogenic RT Process."; RL PLoS ONE 6:E23327-E23327(2011). RN [24] {ECO:0000313|EMBL:ADW83076.1} RP NUCLEOTIDE SEQUENCE. RA Fayzulin R., Alexeyev M.; RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|EMBL:ADZ23173.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6NCrl {ECO:0000313|EMBL:ADZ23173.1}; RA Stewart J.B.; RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:AEV56607.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=WOM/W {ECO:0000313|EMBL:AEV56607.1}; RA Strzalkowska A., Unrug-Bielawska K., Gajewska M.; RT "Mus musculus strain WOM/W mitochondrion, complete genom."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [27] {ECO:0000313|EMBL:BAM93593.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:BAM93593.1}; RA Imanishi H., Takibuchi G., Hayashi J.; RT "Polymorphic mutations in mouse mitochondrial DNA regulate a tumor RT phenotype."; RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases. RN [28] {ECO:0000313|EMBL:BAO42860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAO42860.1}; RX PubMed=24510903; DOI=10.1073/pnas.1318109111; RA Shimizu A., Mito T., Hayashi C., Ogasawara E., Koba R., Negishi I., RA Takenaga K., Nakada K., Hayashi J.; RT "Transmitochondrial mice as models for primary prevention of diseases RT caused by mutation in the tRNALys gene."; RL Proc. Natl. Acad. Sci. U.S.A. 111:3104-3109(2014). RN [29] {ECO:0000313|EMBL:AJE26566.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/KaLwRij {ECO:0000313|EMBL:AJE26566.1}; RA Liu Z.-G.; RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases. RN [30] {ECO:0000313|EMBL:AJK91496.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=M13 {ECO:0000313|EMBL:AJK91522.1}, M17 RC {ECO:0000313|EMBL:AJK91496.1}, M6 {ECO:0000313|EMBL:AJK91535.1}, and RC ME {ECO:0000313|EMBL:AJK91509.1}; RA Wang N.; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. RN [31] {ECO:0000313|EMBL:AKS10722.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6N {ECO:0000313|EMBL:AKS10722.1}; RA Hayashi K., Okamura K., Hata K., Nakabayashi K.; RT "Development of an extension-based assembler and demonstration of RT determining complete mitochondrial genome sequences of several mouse RT strains."; RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases. RN [32] {ECO:0000313|EMBL:QPG85865.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27626666; RA Kauppila JHK, Baines HL, Bratic A, Simard ML, Freyer C, Mourier A, Stamp C, RA Filograna R, Larsson NG, Greaves LC Stewart.JB.; RT "A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA RT Mutations Causing Mitochondrial Disease."; RL Cell Rep. 16:2980-2990(2016). RN [33] {ECO:0000313|EMBL:ART65703.1} RP NUCLEOTIDE SEQUENCE. RA StJohn J.; RT "Mitochondrial DNA haplotypes induce differential patterns of DNA RT methylation that result in differential chromosomal gene expression RT patterns."; RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases. RN [34] {ECO:0000313|EMBL:QPG85865.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30250142; RA Gammage PA, Viscomi C, Simard ML, Costa ASH, Gaude E, Powell CA, RA Van Haute L, McCann BJ, Rebelo-Guiomar P, Cerutti R, Zhang L, Rebar EJ, RA Zeviani M, Frezza C, Stewart JB Minczuk.M.; RT "Genome editing in mitochondria corrects a pathogenic mtDNA mutation in RT vivo."; RL Nat. Med. 24:1691-1695(2018). RN [35] {ECO:0000313|EMBL:QPG85865.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30250143; RA Bacman SR, Kauppila JHK, Pereira CV, Nissanka N, Miranda M, Pinto M, RA Williams SL, Larsson NG, Stewart JB Moraes.CT.; RT "MitoTALEN reduces mutant mtDNA load and restores tRNA(Ala) levels in a RT mouse model of heteroplasmic mtDNA mutation."; RL Nat. Med. 24:1696-1700(2018). RN [36] {ECO:0000313|EMBL:QPG85865.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=33099782; DOI=10.1002/jimd.12324; RA Stewart J.B.; RT "Current progress with mammalian models of mitochondrial DNA disease."; RL J. Inherit. Metab. Dis. 0:0-0(2020). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity and assembly of complex CC I. {ECO:0000256|RuleBase:RU003404}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU003404}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane CC protein {ECO:0000256|ARBA:ARBA00004448}. CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. CC {ECO:0000256|ARBA:ARBA00008200, ECO:0000256|RuleBase:RU003404}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY466499; AAR21205.1; -; Genomic_DNA. DR EMBL; AY533105; AAS01436.1; -; Genomic_DNA. DR EMBL; AY533106; AAS01449.1; -; Genomic_DNA. DR EMBL; AY533107; AAS01462.1; -; Genomic_DNA. DR EMBL; AY533108; AAS01475.1; -; Genomic_DNA. DR EMBL; AY999076; AAX83022.1; -; Genomic_DNA. DR EMBL; EF108330; ABK79103.1; -; Genomic_DNA. DR EMBL; EF108331; ABK79116.1; -; Genomic_DNA. DR EMBL; EF108332; ABK79129.1; -; Genomic_DNA. DR EMBL; EF108333; ABK79142.1; -; Genomic_DNA. DR EMBL; EF108334; ABK79155.1; -; Genomic_DNA. DR EMBL; EF108335; ABK79168.1; -; Genomic_DNA. DR EMBL; EF108336; ABK79181.1; -; Genomic_DNA. DR EMBL; EF108337; ABK79194.1; -; Genomic_DNA. DR EMBL; EF108338; ABK79207.1; -; Genomic_DNA. DR EMBL; EF108339; ABK79220.1; -; Genomic_DNA. DR EMBL; EF108340; ABK79233.1; -; Genomic_DNA. DR EMBL; EF108341; ABK79246.1; -; Genomic_DNA. DR EMBL; EU312160; ABX79712.1; -; Genomic_DNA. DR EMBL; EU312161; ABX79725.1; -; Genomic_DNA. DR EMBL; EU315228; ABX79738.1; -; Genomic_DNA. DR EMBL; EU315229; ABX79751.1; -; Genomic_DNA. DR EMBL; EU450583; ACA01533.1; -; Genomic_DNA. DR EMBL; FJ803909; ACN91105.1; -; Genomic_DNA. DR EMBL; HQ586004; ADR03166.1; -; Genomic_DNA. DR EMBL; HQ877407; ADW83076.1; -; Genomic_DNA. DR EMBL; JF286601; ADZ23173.1; -; Genomic_DNA. DR EMBL; HQ675026; AEN03379.1; -; Genomic_DNA. DR EMBL; HQ675027; AEN03392.1; -; Genomic_DNA. DR EMBL; HQ675028; AEN03405.1; -; Genomic_DNA. DR EMBL; HQ675029; AEN03418.1; -; Genomic_DNA. DR EMBL; HQ675030; AEN03431.1; -; Genomic_DNA. DR EMBL; HQ675031; AEN03444.1; -; Genomic_DNA. DR EMBL; JQ003190; AEV56607.1; -; Genomic_DNA. DR EMBL; KP090294; AJE26566.1; -; Genomic_DNA. DR EMBL; KP260514; AJK91496.1; -; Genomic_DNA. DR EMBL; KP260515; AJK91509.1; -; Genomic_DNA. DR EMBL; KP260516; AJK91522.1; -; Genomic_DNA. DR EMBL; KP260517; AJK91535.1; -; Genomic_DNA. DR EMBL; KR020497; AKS10722.1; -; Genomic_DNA. DR EMBL; KY018919; ART65703.1; -; Genomic_DNA. DR EMBL; AB042524; BAA95650.1; -; Genomic_DNA. DR EMBL; AB042523; BAA95663.1; -; Genomic_DNA. DR EMBL; AB042809; BAA95805.1; -; Genomic_DNA. DR EMBL; AB049357; BAB13811.1; -; Genomic_DNA. DR EMBL; AK140457; BAE24397.1; -; mRNA. DR EMBL; AP013030; BAM93593.1; -; Genomic_DNA. DR EMBL; AP014540; BAO42860.1; -; Genomic_DNA. DR EMBL; AP014541; BAO42873.1; -; Genomic_DNA. DR EMBL; AJ489607; CAD33917.1; -; Genomic_DNA. DR EMBL; AJ512208; CAD54442.1; -; Genomic_DNA. DR EMBL; MT937073; QPG85865.1; -; Genomic_DNA. DR RefSeq; NP_904338.1; NC_005089.1. DR RefSeq; YP_220560.1; NC_006914.1. DR Antibodypedia; 35363; 253 antibodies. DR GeneID; 17721; -. DR GeneID; 3338890; -. DR KEGG; mmu:17721; -. DR CTD; 4540; -. DR MGI; MGI:102496; mt-Nd5. DR VEuPathDB; HostDB:ENSMUSG00000064367; -. DR HOGENOM; CLU_007100_6_0_1; -. DR OMA; GVGIMSF; -. DR OrthoDB; 526738at2759; -. DR ChiTaRS; mt-Nd5; mouse. DR Bgee; ENSMUSG00000064367; Expressed in Ammon's horn and 82 other tissues. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl. DR GO; GO:0043005; C:neuron projection; IEA:Ensembl. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl. DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:Ensembl. DR GO; GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl. DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl. DR GO; GO:0010243; P:response to organonitrogen compound; IEA:Ensembl. DR InterPro; IPR010934; NADH_DH_su5_C. DR InterPro; IPR003945; NADHpl_OxRdtase_5. DR InterPro; IPR001750; ND/Mrp_mem. DR InterPro; IPR001516; Proton_antipo_N. DR Pfam; PF06455; NADH5_C; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR Pfam; PF00662; Proton_antipo_N; 1. DR TIGRFAMs; TIGR01974; NDH_I_L; 1. PE 1: Evidence at protein level; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003404}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128, KW ECO:0000256|RuleBase:RU003404}; KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792}; KW NAD {ECO:0000256|RuleBase:RU003404}; KW Oxidoreductase {ECO:0000313|EMBL:AAR21205.1}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003404}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU003404}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003404}; KW Ubiquinone {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 6..27 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 39..56 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 84..105 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 117..134 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 140..160 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 172..191 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 211..233 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 245..266 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 272..294 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 301..319 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 325..347 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 368..386 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 406..432 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 453..472 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 484..504 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT TRANSMEM 586..604 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003404" FT DOMAIN 66..121 FT /note="Proton_antipo_N" FT /evidence="ECO:0000259|Pfam:PF00662" FT DOMAIN 134..418 FT /note="Proton_antipo_M" FT /evidence="ECO:0000259|Pfam:PF00361" FT DOMAIN 422..601 FT /note="NADH5_C" FT /evidence="ECO:0000259|Pfam:PF06455" SQ SEQUENCE 607 AA; 68475 MW; 31C10862CDC78B10 CRC64; MNIFTTSILL IFILLLSPIL ISMSNLIKHI NFPLYTTTSI KFSFIISLLP LLMFFHNNME YMITTWHWVT MNSMELKMSF KTDFFSILFT SVALFVTWSI MQFSSWYMHS DPNINRFIKY LTLFLITMLI LTSANNMFQL FIGWEGVGIM SFLLIGWWYG RTDANTAALQ AILYNRIGDI GFILAMVWFS LNMNSWELQQ IMFSNNNDNL IPLMGLLIAA TGKSAQFGLH PWLPSAMEGP TPVSALLHSS TMVVAGIFLL VRFHPLTTNN NFILTTMLCL GALTTLFTAI CALTQNDIKK IIAFSTSSQL GLMMVTLGMN QPHLAFLHIC THAFFKAMLF MCSGSIIHSL ADEQDIRKMG NITKIMPFTS SCLVIGSLAL TGMPFLTGFY SKDLIIEAIN TCNTNAWALL ITLIATSMTA MYSMRIIYFV TMTKPRFPPL ISINENDPDL MNPIKRLAFG SIFAGFVISY NIPPTSIPVL TMPWFLKTTA LIISVLGFLI ALELNNLTMK LSMNKANPYS SFSTLLGFFP SIIHRITPMK SLNLSLKTSL TLLDLIWLEK TIPKSTSTLH TNMTTLTTNQ KGLIKLYFMS FLINIILIII LYSINLE //