ID Q9MD82_MOUSE Unreviewed; 607 AA. AC Q9MD82; DT 01-OCT-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2000, sequence version 1. DT 11-DEC-2013, entry version 113. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5; DE EC=1.6.5.3; GN Name=mt-Nd5; Synonyms=mt-Nd6, ND5, Nd5; OS Mus musculus (Mouse). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=SAMP1, SAMP8, and SAMR1; TISSUE=Liver; RA Mori M., Higuchi K., Tanaka M.; RT "Unique transitional nucleotide mutations in the mitochondrial DNA of RT Senescence-accelerated Mouse (SAM) strains."; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C3H/He; RA Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.; RT "Unique mutations in mitochondrial DNA of Senescence-Accelerated Mouse RT (SAM) strains."; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RG The RIKEN Genome Exploration Research Group Phase II Team and the RG FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group RG Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Balb/cJ, and C3H/An; TISSUE=Connective, and Platelets; RX PubMed=12554686; DOI=10.1093/hmg/ddg021; RA Acin-Perez R., Bayona-Bafaluy M., Bueno M., Machicado C., RA Fernandez-Silva P., Perez-Martos A., Montoya J., Lopez-Perez M.J., RA Sancho J., Enriquez J.A.; RT "An intragenic suppressor in the cytochrome c oxidase I gene of mouse RT mitochondrial DNA."; RL Hum. Mol. Genet. 12:329-339(2003). RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Balb/cJ, C3H/An, and C57BL/6J; RC TISSUE=Connective, and Platelets; RX PubMed=12954771; DOI=10.1093/nar/gkg739; RA Bayona-Bafaluy M.P., Acin-Perez R., Mullikin J.C., Park J.S., RA Moreno-Loshuertos R., Hu P., Perez-Martos A., Fernandez-Silva P., RA Bai Y., Enriquez J.A.; RT "Revisiting the mouse mitochondrial DNA sequence."; RL Nucleic Acids Res. 31:5349-5355(2003). RN [10] RP NUCLEOTIDE SEQUENCE. RC STRAIN=ALR/Lt, ALS/Lt, NOD/LtJ, and NON/Lt; RA Gusdon A.M., Spirina O., Bykhovskaya Y., Fischel-Ghodsia N., RA Libert T., Trucco M., Mathews C.E.; RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases. RN [11] RP NUCLEOTIDE SEQUENCE. RC STRAIN=ALR/Lt, ALS/Lt, NOD/LtJ, and NON/Lt; RA Mathews C.E., Leiter E.H., Spirina O., Bykhovskaya Y., RA Fischel-Ghodsian N.; RT "The ALR/Lt Mouse: Contribution of the Mitochondrial Genome in RT Resistance Against both Chemically-Induced and Autoimmune Diabetes."; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [13] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group RG (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [14] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group RG (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [15] RP NUCLEOTIDE SEQUENCE. RC STRAIN=CBA/J; RX PubMed=17013393; DOI=10.1038/ng1897; RA Moreno-Loshuertos R., Acin-Perez R., Fernandez-Silva P., Movilla N., RA Perez-Martos A., de Cordoba S.R., Gallardo M.E., Enriquez J.A.; RT "Differences in reactive oxygen species production explain the RT phenotypes associated with common mouse mitochondrial DNA variants."; RL Nat. Genet. 38:1261-1268(2006). RN [16] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129S1/SvImJ, A/J, AKR/J, BALB/cByJ, BTBR T+ tf/J, C3H/HeJ, RC C57BL/6J, DBA/2J, FVB/NJ, KK/HlJ, NOD/LtJ, and NZW/LacJ; RX PubMed=17284675; DOI=10.1101/gr.5941007; RA Goios A., Pereira L., Bogue M., Macaulay V., Amorim A.; RT "mtDNA phylogeny and evolution of laboratory mouse strains."; RL Genome Res. 17:293-298(2007). RN [17] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MRL/MpJ; TISSUE=Heart; RX PubMed=18761428; DOI=10.1016/j.mito.2008.07.007; RA Sachadyn P., Zhang X.M., Clark L.D., Naviaux R.K., Heber-Katz E.; RT "Naturally occurring mitochondrial DNA heteroplasmy in the MRL RT mouse."; RL Mitochondrion 8:358-366(2008). RN [18] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6NCrl; RX PubMed=18232733; DOI=10.1371/journal.pbio.0060010; RA Stewart J.B., Freyer C., Elson J.L., Wredenberg A., Cansu Z., RA Trifunovic A., Larsson N.G.; RT "Strong purifying selection in transmission of mammalian mitochondrial RT DNA."; RL PLoS Biol. 6:E10-E10(2008). RN [19] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C3H/An, and C57BL/6; RX PubMed=18388260; DOI=10.1126/science.1156906; RA Ishikawa K., Takenaga K., Akimoto M., Koshikawa N., Yamaguchi A., RA Imanishi H., Nakada K., Honma Y., Hayashi J.; RT "ROS-generating mitochondrial DNA mutations can regulate tumor cell RT metastasis."; RL Science 320:661-664(2008). RN [20] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C3H/An; RA Ishikawa K., Toyama-Sorimachi N., Nakada K., Morimoto M., Niikura M., RA Takenaga K., Yonekawa H., Hayashi J.-I.; RT "Innate immunity in the host mice targets cells with polymorphic RT mutations in mtDNA."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [21] RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN/aW; RA Gajewska M., Unrug-Bielawska K., Strzalkowska A.; RT "Mitochondrion complete sequence of BN/aW mouse strain."; RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases. RN [22] RP NUCLEOTIDE SEQUENCE. RC STRAIN=FVB/NJ; RX PubMed=21858071; DOI=10.1371/journal.pone.0023327; RA Seoane M., Mosquera-Miguel A., Gonzalez T., Fraga M., Salas A., RA Costoya J.A.; RT "The Mitochondrial Genome Is a 'Genetic Sanctuary' during the RT Oncogenic Process."; RL PLoS ONE 6:E23327-E23327(2011). RN [23] RP NUCLEOTIDE SEQUENCE. RA Fayzulin R., Alexeyev M.; RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases. RN [24] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6NCrl; RA Stewart J.B.; RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases. RN [25] RP NUCLEOTIDE SEQUENCE. RC STRAIN=WOM/W; RA Strzalkowska A., Unrug-Bielawska K., Gajewska M.; RT "Mus musculus strain WOM/W mitochondrion, complete genom."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [26] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6; RA Imanishi H., Takibuchi G., Hayashi J.; RT "Polymorphic mutations in mouse mitochondrial DNA regulate a tumor RT phenotype."; RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone (By similarity). CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + CC ubiquinol + 4 H(+)(Out). CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY172335; AAN85132.1; -; Genomic_DNA. DR EMBL; AY466499; AAR21205.1; -; Genomic_DNA. DR EMBL; AY533105; AAS01436.1; -; Genomic_DNA. DR EMBL; AY533106; AAS01449.1; -; Genomic_DNA. DR EMBL; AY533107; AAS01462.1; -; Genomic_DNA. DR EMBL; AY533108; AAS01475.1; -; Genomic_DNA. DR EMBL; AY999076; AAX83022.1; -; Genomic_DNA. DR EMBL; EF108330; ABK79103.1; -; Genomic_DNA. DR EMBL; EF108331; ABK79116.1; -; Genomic_DNA. DR EMBL; EF108332; ABK79129.1; -; Genomic_DNA. DR EMBL; EF108333; ABK79142.1; -; Genomic_DNA. DR EMBL; EF108334; ABK79155.1; -; Genomic_DNA. DR EMBL; EF108335; ABK79168.1; -; Genomic_DNA. DR EMBL; EF108336; ABK79181.1; -; Genomic_DNA. DR EMBL; EF108337; ABK79194.1; -; Genomic_DNA. DR EMBL; EF108338; ABK79207.1; -; Genomic_DNA. DR EMBL; EF108339; ABK79220.1; -; Genomic_DNA. DR EMBL; EF108340; ABK79233.1; -; Genomic_DNA. DR EMBL; EF108341; ABK79246.1; -; Genomic_DNA. DR EMBL; EU312160; ABX79712.1; -; Genomic_DNA. DR EMBL; EU312161; ABX79725.1; -; Genomic_DNA. DR EMBL; EU315228; ABX79738.1; -; Genomic_DNA. DR EMBL; EU315229; ABX79751.1; -; Genomic_DNA. DR EMBL; EU450583; ACA01533.1; -; Genomic_DNA. DR EMBL; FJ803909; ACN91105.1; -; Genomic_DNA. DR EMBL; HQ586004; ADR03166.1; -; Genomic_DNA. DR EMBL; HQ877407; ADW83076.1; -; Genomic_DNA. DR EMBL; JF286601; ADZ23173.1; -; Genomic_DNA. DR EMBL; HQ675026; AEN03379.1; -; Genomic_DNA. DR EMBL; HQ675027; AEN03392.1; -; Genomic_DNA. DR EMBL; HQ675028; AEN03405.1; -; Genomic_DNA. DR EMBL; HQ675029; AEN03418.1; -; Genomic_DNA. DR EMBL; HQ675030; AEN03431.1; -; Genomic_DNA. DR EMBL; HQ675031; AEN03444.1; -; Genomic_DNA. DR EMBL; JQ003190; AEV56607.1; -; Genomic_DNA. DR EMBL; AB042524; BAA95650.1; -; Genomic_DNA. DR EMBL; AB042523; BAA95663.1; -; Genomic_DNA. DR EMBL; AB042809; BAA95805.1; -; Genomic_DNA. DR EMBL; AB049357; BAB13811.1; -; Genomic_DNA. DR EMBL; AK140457; BAE24397.1; -; mRNA. DR EMBL; AP013030; BAM93593.1; -; Genomic_DNA. DR EMBL; AJ489607; CAD33917.1; -; Genomic_DNA. DR EMBL; AJ512208; CAD54442.1; -; Genomic_DNA. DR IPI; IPI00480233; -. DR RefSeq; NP_904338.1; NC_005089.1. DR STRING; 10090.ENSMUSP00000081001; -. DR GeneID; 17721; -. DR KEGG; mmu:17721; -. DR CTD; 4540; -. DR MGI; MGI:102496; mt-Nd5. DR GeneTree; ENSGT00730000111303; -. DR HOVERGEN; HBG108343; -. DR InParanoid; Q9MD82; -. DR KO; K03883; -. DR OMA; KLDYFSM; -. DR OrthoDB; EOG75QR54; -. DR ProtClustDB; MTH00108; -. DR NextBio; 292347; -. DR Genevestigator; Q9MD82; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005739; C:mitochondrion; IDA:MGI. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0003954; F:NADH dehydrogenase activity; IDA:MGI. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR InterPro; IPR010934; NADH_DH_su5_C. DR InterPro; IPR001750; NADH_UbQ/plastoQ_OxRdtase. DR InterPro; IPR001516; NADH_UbQ_OxRdtase_chain5/L_N. DR InterPro; IPR003945; NADHpl_OxRdtase_5. DR Pfam; PF06455; NADH5_C; 1. DR Pfam; PF00361; Oxidored_q1; 1. DR Pfam; PF00662; Oxidored_q1_N; 1. DR TIGRFAMs; TIGR01974; NDH_I_L; 1. PE 2: Evidence at transcript level; KW Complete proteome; Electron transport; Membrane; Mitochondrion; KW Mitochondrion inner membrane; NAD; Oxidoreductase; Reference proteome; KW Respiratory chain; Transmembrane; Transmembrane helix; Transport; KW Ubiquinone. SQ SEQUENCE 607 AA; 68475 MW; 31C10862CDC78B10 CRC64; MNIFTTSILL IFILLLSPIL ISMSNLIKHI NFPLYTTTSI KFSFIISLLP LLMFFHNNME YMITTWHWVT MNSMELKMSF KTDFFSILFT SVALFVTWSI MQFSSWYMHS DPNINRFIKY LTLFLITMLI LTSANNMFQL FIGWEGVGIM SFLLIGWWYG RTDANTAALQ AILYNRIGDI GFILAMVWFS LNMNSWELQQ IMFSNNNDNL IPLMGLLIAA TGKSAQFGLH PWLPSAMEGP TPVSALLHSS TMVVAGIFLL VRFHPLTTNN NFILTTMLCL GALTTLFTAI CALTQNDIKK IIAFSTSSQL GLMMVTLGMN QPHLAFLHIC THAFFKAMLF MCSGSIIHSL ADEQDIRKMG NITKIMPFTS SCLVIGSLAL TGMPFLTGFY SKDLIIEAIN TCNTNAWALL ITLIATSMTA MYSMRIIYFV TMTKPRFPPL ISINENDPDL MNPIKRLAFG SIFAGFVISY NIPPTSIPVL TMPWFLKTTA LIISVLGFLI ALELNNLTMK LSMNKANPYS SFSTLLGFFP SIIHRITPMK SLNLSLKTSL TLLDLIWLEK TIPKSTSTLH TNMTTLTTNQ KGLIKLYFMS FLINIILIII LYSINLE //