ID   Q9M7R8_ACHBI            Unreviewed;       596 AA.
AC   Q9M7R8;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   08-APR-2008, entry version 28.
DE   Triosephosphate isomerase + glyceraldehyde-3-phosphate dehydrogenase.
GN   Name=TigA;
OS   Achlya bisexualis (Water mold).
OC   Eukaryota; stramenopiles; Oomycetes; Saprolegniales; Saprolegniaceae;
OC   Achlya.
OX   NCBI_TaxID=4766;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=20142334; PubMed=10677844;
RA   Liaud M.F., Lichtle C., Apt K., Martin W., Cerff R.;
RT   "Compartment-specific isoforms of TPI and GAPDH are imported into
RT   diatom mitochondria as a fusion protein: evidence in favor of a
RT   mitochondrial origin of the eukaryotic glycolytic pathway.";
RL   Mol. Biol. Evol. 17:213-223(2000).
CC   -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone
CC       phosphate.
CC   -!- SIMILARITY: Belongs to the glyceraldehyde-3-phosphate
CC       dehydrogenase family.
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DR   EMBL; AF063107; AAF44720.1; -; mRNA.
DR   HSSP; P00357; 4GPD.
DR   GO; GO:0004365; F:glyceraldehyde-3-phosphate dehydrogenase (p...; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:InterPro.
DR   GO; GO:0006096; P:glycolysis; IEA:InterPro.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000173; GlycerAld_3-P_DHase.
DR   InterPro; IPR006424; Glyceraldehyde-3-P_DHase_1.
DR   InterPro; IPR000652; Triophos_ismrse.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR10836; GAP_DH; 1.
DR   Pfam; PF02800; Gp_dh_C; 1.
DR   Pfam; PF00044; Gp_dh_N; 1.
DR   Pfam; PF00121; TIM; 1.
DR   PRINTS; PR00078; G3PDHDRGNASE.
DR   ProDom; PD001005; Triophos_ismrse; 1.
DR   TIGRFAMs; TIGR01534; GAPDH-I; 1.
DR   TIGRFAMs; TIGR00419; tim; 1.
DR   PROSITE; PS00071; GAPDH; 1.
DR   PROSITE; PS00171; TIM; 1.
PE   2: Evidence at transcript level;
KW   Gluconeogenesis; Glycolysis; Isomerase; Oxidoreductase; Pentose shunt.
SQ   SEQUENCE   596 AA;  64255 MW;  D4CA852D53F8AD31 CRC64;
     MQVRRFSSVA RKFFVGGNWK CNGSLSQAQS LVDTLNTATI PKNVEVVVAP ASIHALSVKS
     SLRKDIGVSG QDTWSRGNGA FTGEVSAEML KDAGINYTII GHSERRQKGE TNEEVASKAG
     YALSKGVSVI ACIGETKIER EAQKTMQVVT EQLAAYAKNI TDWSNVVIAY EPVWAIGTGL
     TATPEQAQEV HAGIRSWLKQ NVSSAVADAT RIIYGGSVTA GNAAELSKKA DIDGFLVGGA
     SLKPDFLSII NCQNDKAHQG GPVNIAINGF GRIGRLVLRA AQTNPLLNVV AVNDPFIPTE
     YMEYMLKHDT VHGHFDGTVR HEGDHIIVND RKIRVFGEKD PKAIKWGESD VEYVVESTGA
     FTTKEKASAH LLNGPRKVVI SAPSADAPMF VVGVNHDKYD PSMNIVSNAS CTTNCLAPLA
     KVVNDKFGII EGLMTTVHAV TATQLTVDGP SKKDWRGGRA ACFNIIPSST GAAKAVGKVI
     PELNGKLTGM SFRVPTANVS VVDLTVRLRN KASYEDIKAA IKYASENELR GILGYTDTAV
     VSSDFISDPR SSIFDADAGI VLTDDFVKLV SWYDNEWGYS NRVLDLITHM VHTERQ
//