ID   Q9M7R8      PRELIMINARY;      PRT;   596 AA.
AC   Q9M7R8;
DT   01-OCT-2000 (TrEMBLrel. 15, Created)
DT   01-OCT-2000 (TrEMBLrel. 15, Last sequence update)
DT   01-OCT-2003 (TrEMBLrel. 25, Last annotation update)
DE   Triosephosphate isomerase + glyceraldehyde-3-phosphate dehydrogenase
DE   (EC 5.3.1.1) (TIM).
GN   TIGA.
OS   Achlya bisexualis (Water mold).
OC   Eukaryota; stramenopiles; Oomycetes; Saprolegniales; Saprolegniaceae;
OC   Achlya.
OX   NCBI_TaxID=4766;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=20142334; PubMed=10677844;
RA   Liaud M.-F., Lichtle C., Apt K., Martin W., Cerff R.;
RT   "Compartment-Specific Isoforms of TPI and GAPDH are Imported into
RT   Diatom Mitochondria as a Fusion Protein: Evidence in Favor of a
RT   Mitochondrial Origin of the Eukaryotic Glycolytic Pathway.";
RL   Mol. Biol. Evol. 17:213-223(2000).
CC   -!- CATALYTIC ACTIVITY: D-GLYCERALDEHYDE 3-PHOSPHATE = GLYCERONE
CC       PHOSPHATE.
CC   -!- PATHWAY: PLAYS AN IMPORTANT ROLE IN SEVERAL METABOLIC PATHWAYS.
CC   -!- SIMILARITY: BELONGS TO THE TRIOSEPHOSPHATE ISOMERASE FAMILY.
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DR   EMBL; AF063107; AAF44720.1; -.
DR   HSSP; P00357; 4GPD.
DR   GO; GO:0004365; F:glyceraldehyde-3-phosphate dehydrogenase (p...; IEA.
DR   GO; GO:0016853; F:isomerase activity; IEA.
DR   GO; GO:0004807; F:triose-phosphate isomerase activity; IEA.
DR   GO; GO:0006633; P:fatty acid biosynthesis; IEA.
DR   GO; GO:0006094; P:gluconeogenesis; IEA.
DR   GO; GO:0006096; P:glycolysis; IEA.
DR   GO; GO:0008152; P:metabolism; IEA.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA.
DR   InterPro; IPR006424; GAPDH-I.
DR   InterPro; IPR000173; GAP_dhdrogenase.
DR   InterPro; IPR000652; Triophos_ismrse.
DR   Pfam; PF00044; gpdh; 1.
DR   Pfam; PF02800; gpdh_C; 1.
DR   Pfam; PF00121; TIM; 1.
DR   PRINTS; PR00078; G3PDHDRGNASE.
DR   ProDom; PD001005; Triophos_ismrse; 1.
DR   TIGRFAMs; TIGR01534; GAPDH-I; 1.
DR   TIGRFAMs; TIGR00419; tim; 1.
DR   PROSITE; PS00071; GAPDH; 1.
DR   PROSITE; PS00171; TIM; 1.
KW   Fatty acid biosynthesis; Gluconeogenesis; Glycolysis; Isomerase;
KW   Pentose shunt.
SQ   SEQUENCE   596 AA;  64255 MW;  D4CA852D53F8AD31 CRC64;
     MQVRRFSSVA RKFFVGGNWK CNGSLSQAQS LVDTLNTATI PKNVEVVVAP ASIHALSVKS
     SLRKDIGVSG QDTWSRGNGA FTGEVSAEML KDAGINYTII GHSERRQKGE TNEEVASKAG
     YALSKGVSVI ACIGETKIER EAQKTMQVVT EQLAAYAKNI TDWSNVVIAY EPVWAIGTGL
     TATPEQAQEV HAGIRSWLKQ NVSSAVADAT RIIYGGSVTA GNAAELSKKA DIDGFLVGGA
     SLKPDFLSII NCQNDKAHQG GPVNIAINGF GRIGRLVLRA AQTNPLLNVV AVNDPFIPTE
     YMEYMLKHDT VHGHFDGTVR HEGDHIIVND RKIRVFGEKD PKAIKWGESD VEYVVESTGA
     FTTKEKASAH LLNGPRKVVI SAPSADAPMF VVGVNHDKYD PSMNIVSNAS CTTNCLAPLA
     KVVNDKFGII EGLMTTVHAV TATQLTVDGP SKKDWRGGRA ACFNIIPSST GAAKAVGKVI
     PELNGKLTGM SFRVPTANVS VVDLTVRLRN KASYEDIKAA IKYASENELR GILGYTDTAV
     VSSDFISDPR SSIFDADAGI VLTDDFVKLV SWYDNEWGYS NRVLDLITHM VHTERQ
//