ID Q9M7R8 PRELIMINARY; PRT; 596 AA. AC Q9M7R8; DT 01-OCT-2000 (TrEMBLrel. 15, Created) DT 01-OCT-2000 (TrEMBLrel. 15, Last sequence update) DT 01-JUN-2003 (TrEMBLrel. 24, Last annotation update) DE Triosephosphate isomerase + glyceraldehyde-3-phosphate dehydrogenase DE (EC 5.3.1.1) (TIM). GN TIGA. OS Achlya bisexualis (Water mold). OC Eukaryota; stramenopiles; Oomycetes; Saprolegniales; Saprolegniaceae; OC Achlya. OX NCBI_TaxID=4766; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=20142334; PubMed=10677844; RA Liaud M.-F., Lichtle C., Apt K., Martin W., Cerff R.; RT "Compartment-Specific Isoforms of TPI and GAPDH are Imported into RT Diatom Mitochondria as a Fusion Protein: Evidence in Favor of a RT Mitochondrial Origin of the Eukaryotic Glycolytic Pathway."; RL Mol. Biol. Evol. 17:213-223(2000). CC -!- CATALYTIC ACTIVITY: D-GLYCERALDEHYDE 3-PHOSPHATE = GLYCERONE CC PHOSPHATE. CC -!- PATHWAY: PLAYS AN IMPORTANT ROLE IN SEVERAL METABOLIC PATHWAYS. CC -!- SIMILARITY: BELONGS TO THE TRIOSEPHOSPHATE ISOMERASE FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF063107; AAF44720.1; -. DR HSSP; P00357; 4GPD. DR GO; GO:0004365; F:glyceraldehyde 3-phosphate dehydrogenase (p...; IEA. DR GO; GO:0016853; F:isomerase activity; IEA. DR GO; GO:0004807; F:triose-phosphate isomerase activity; IEA. DR GO; GO:0006633; P:fatty acid biosynthesis; IEA. DR GO; GO:0006094; P:gluconeogenesis; IEA. DR GO; GO:0006096; P:glycolysis; IEA. DR GO; GO:0008152; P:metabolism; IEA. DR GO; GO:0006098; P:pentose-phosphate shunt; IEA. DR InterPro; IPR006424; GAPDH-I. DR InterPro; IPR000173; GAP_dhdrogenase. DR InterPro; IPR000652; Triophos_ismrse. DR Pfam; PF00044; gpdh; 1. DR Pfam; PF02800; gpdh_C; 1. DR Pfam; PF00121; TIM; 1. DR PRINTS; PR00078; G3PDHDRGNASE. DR ProDom; PD001005; Triophos_ismrse; 1. DR TIGRFAMs; TIGR01534; GAPDH-I; 1. DR TIGRFAMs; TIGR00419; tim; 1. DR PROSITE; PS00071; GAPDH; 1. DR PROSITE; PS00171; TIM; 1. KW Fatty acid biosynthesis; Gluconeogenesis; Glycolysis; Isomerase; KW Pentose shunt. SQ SEQUENCE 596 AA; 64255 MW; D4CA852D53F8AD31 CRC64; MQVRRFSSVA RKFFVGGNWK CNGSLSQAQS LVDTLNTATI PKNVEVVVAP ASIHALSVKS SLRKDIGVSG QDTWSRGNGA FTGEVSAEML KDAGINYTII GHSERRQKGE TNEEVASKAG YALSKGVSVI ACIGETKIER EAQKTMQVVT EQLAAYAKNI TDWSNVVIAY EPVWAIGTGL TATPEQAQEV HAGIRSWLKQ NVSSAVADAT RIIYGGSVTA GNAAELSKKA DIDGFLVGGA SLKPDFLSII NCQNDKAHQG GPVNIAINGF GRIGRLVLRA AQTNPLLNVV AVNDPFIPTE YMEYMLKHDT VHGHFDGTVR HEGDHIIVND RKIRVFGEKD PKAIKWGESD VEYVVESTGA FTTKEKASAH LLNGPRKVVI SAPSADAPMF VVGVNHDKYD PSMNIVSNAS CTTNCLAPLA KVVNDKFGII EGLMTTVHAV TATQLTVDGP SKKDWRGGRA ACFNIIPSST GAAKAVGKVI PELNGKLTGM SFRVPTANVS VVDLTVRLRN KASYEDIKAA IKYASENELR GILGYTDTAV VSSDFISDPR SSIFDADAGI VLTDDFVKLV SWYDNEWGYS NRVLDLITHM VHTERQ //