ID GLYA_BACHD STANDARD; PRT; 413 AA. AC Q9K6G4; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 01-OCT-2004 (Rel. 45, Last annotation update) DE Serine hydroxymethyltransferase (EC 2.1.2.1) (Serine methylase) DE (SHMT). GN Name=glyA; OrderedLocusNames=BH3765; OS Bacillus halodurans. OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus. OX NCBI_TaxID=86665; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=C-125 / JCM 9153; RX MEDLINE=20512582; PubMed=11058132; DOI=10.1093/nar/28.21.4317; RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., RA Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., RA Horikoshi K.; RT "Complete genome sequence of the alkaliphilic bacterium Bacillus RT halodurans and genomic sequence comparison with Bacillus subtilis."; RL Nucleic Acids Res. 28:4317-4331(2000). CC -!- FUNCTION: Interconversion of serine and glycine. CC -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + glycine + CC H(2)O = tetrahydrofolate + L-serine. CC -!- COFACTOR: Pyridoxal phosphate (By similarity). CC -!- PATHWAY: Key enzyme in the biosynthesis of purines, lipids, CC hormones and other components. CC -!- SUBUNIT: Homotetramer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity). CC -!- SIMILARITY: Belongs to the SHMT family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP001519; BAB07484.1; -. DR PIR; E84120; E84120. DR HSSP; P00477; 1DFO. DR HAMAP; MF_00051; -; 1. DR InterPro; IPR001085; Gly_Hymtfrase. DR Pfam; PF00464; SHMT; 1. DR PIRSF; PIRSF000412; SHMT; 1. DR PROSITE; PS00096; SHMT; 1. KW Complete proteome; One-carbon metabolism; Pyridoxal phosphate; KW Transferase. FT BINDING 226 226 Pyridoxal phosphate (By similarity). SQ SEQUENCE 413 AA; 45233 MW; 1133BA2083E3B6BA CRC64; MSTLQSKDPK VFEAVQQELG RQRDKIELIA SENFVSEAVM EAQSSVLTNK YAEGYPGRRY YGGCEYVDIV EDLARDRAKE IFGGEHVNVQ PHSGAQANMA VYFTILEHGD TVLGMNLSHG GHLTHGSPVN FSGIQYNFVE YGVDKESQRI DYEEVRRLAK EHQPKMIVAG ASAYPREIDF AKFREIADEV GAYLMVDMAH IAGLVAAGLH QNPVPHSHFV TTTTHKTLRG PRGGMIICNE EFAKQIDKSI FPGIQGGPLM HVIAAKAVAF GEALQPEFKS YGEAIIRNAK RLGEKLTSEG IDLVSGGTDN HLLLLDLRSL GLTGKVAEKA LDDVGITTNK NTIPFDPESP FVTSGIRIGT AAVTSRGLDE EAMDEIGATI ALTLKNVDNE EKMNEARERV DALTAKFPMY PNL //