ID T2R9_MOUSE STANDARD; PRT; 300 AA. AC Q9JKT4; DT 15-SEP-2003 (Rel. 42, Created) DT 15-SEP-2003 (Rel. 42, Last sequence update) DT 15-SEP-2003 (Rel. 42, Last annotation update) DE Taste receptor type 2 member 9 (T2R9) (Taste receptor type 2 member DE 5) (T2R5). GN TAS2R5. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A., AND TOPOLOGY. RC STRAIN=129/SvJ; RX MEDLINE=20222571; PubMed=10761934; RA Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., RA Zuker C.S.; RT "A novel family of mammalian taste receptors."; RL Cell 100:693-702(2000). RN [2] RP CHARACTERIZATION. RX MEDLINE=20222572; PubMed=10761935; RA Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., RA Zuker C.S., Ryba N.J.; RT "T2Rs function as bitter taste receptors."; RL Cell 100:703-711(2000). RN [3] RP REVIEW. RX MEDLINE=22135574; PubMed=12139982; RA Montmayeur J.-P., Matsunami H.; RT "Receptors for bitter and sweet taste."; RL Curr. Opin. Neurobiol. 12:366-371(2002). RN [4] RP REVIEW. RX MEDLINE=21634924; PubMed=11696554; RA Margolskee R.F.; RT "Molecular mechanisms of bitter and sweet taste transduction."; RL J. Biol. Chem. 277:1-4(2002). RN [5] RP REVIEW. RX MEDLINE=22469025; PubMed=12581520; RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., RA Zuker C.S., Ryba N.J.; RT "Coding of sweet, bitter, and umami tastes: different receptor cells RT sharing similar signaling pathways."; RL Cell 112:293-301(2003). CC -!- FUNCTION: Receptor that may play a role in the perception of CC bitterness and is gustducin-linked. May play a role in sensing the CC chemical composition of the gastrointestinal content. The activity CC of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 CC activation and lead to the gating of TRPM5. Functions as a ligand CC for cyclohexamide. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells CC of the tongue and palate epithelium and exclusively in gustducin- CC positive cells. Expressed in gastric and duodenal tissues. CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited CC number of bitter compounds; individual taste cells can CC discriminate among bitter stimuli. CC -!- SIMILARITY: Belongs to family T2R of G-protein coupled receptors. CC -!- CAUTION: This protein was previously referred to T2R5, but due to CC its high similarity towards both the human and rat T2R9 sequences CC it is considered to be T2R9. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF227147; AAF43920.1; -. DR InterPro; IPR007960; TAS2R. DR Pfam; PF05296; TAS2R; 1. KW Receptor; G-protein coupled receptor; Transmembrane. FT DOMAIN 1 7 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 8 28 1 (POTENTIAL). FT DOMAIN 29 43 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 44 64 2 (POTENTIAL). FT DOMAIN 65 87 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 88 108 3 (POTENTIAL). FT DOMAIN 109 128 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 129 149 4 (POTENTIAL). FT DOMAIN 150 181 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 182 202 5 (POTENTIAL). FT DOMAIN 203 233 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 234 254 6 (POTENTIAL). FT DOMAIN 255 259 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 260 280 7 (POTENTIAL). FT DOMAIN 281 300 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 161 161 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 300 AA; 34416 MW; 92AD449C68FB85EB CRC64; MLSAAEGILL SIATVEAGLG VLGNTFIALV NCMDWAKNNK LSMTGFLLIG LATSRIFIVW LLTLDAYAKL FYPSKYFSSS LIEIISYIWM TVNHLTVWFA TSLSIFYFLK IANFSDCVFL WLKRRTDKAF VFLLGCLLTS WVISFSFVVK VMKDGKVNHR NRTSEMYWEK RQFTINYVFL NIGVISLFMM TLTACFLLIM SLWRHSRQMQ SGVSGFRDLN TEAHVKAIKF LISFIILFVL YFIGVSIEII CIFIPENKLL FIFGFTTASI YPCCHSFILI LSNSQLKQAF VKVLQGLKFF //