ID TR105_MOUSE Reviewed; 300 AA. AC Q9JKT4; DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 18-APR-2012, entry version 73. DE RecName: Full=Taste receptor type 2 member 105; DE Short=T2R105; DE AltName: Full=Taste receptor type 2 member 5; DE Short=T2R5; DE AltName: Full=Taste receptor type 2 member 9; DE Short=T2R9; GN Name=Tas2r105; Synonyms=Tas2r5, Tas2r9; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TOPOLOGY. RC STRAIN=129/SvJ; RX MEDLINE=20222571; PubMed=10761934; DOI=10.1016/S0092-8674(00)80705-9; RA Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., RA Zuker C.S.; RT "A novel family of mammalian taste receptors."; RL Cell 100:693-702(2000). RN [2] RP FUNCTION, AND VARIANTS ILE-44; ASP-155 AND ARG-294. RX MEDLINE=20222572; PubMed=10761935; DOI=10.1016/S0092-8674(00)80706-0; RA Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., RA Zuker C.S., Ryba N.J.P.; RT "T2Rs function as bitter taste receptors."; RL Cell 100:703-711(2000). RN [3] RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=15759003; DOI=10.1038/nature03352; RA Mueller K.L., Hoon M.A., Erlenbach I., Chandrashekar J., Zuker C.S., RA Ryba N.J.; RT "The receptors and coding logic for bitter taste."; RL Nature 434:225-229(2005). RN [4] RP REVIEW. RX MEDLINE=22135574; PubMed=12139982; DOI=10.1016/S0959-4388(02)00345-8; RA Montmayeur J.-P., Matsunami H.; RT "Receptors for bitter and sweet taste."; RL Curr. Opin. Neurobiol. 12:366-371(2002). RN [5] RP REVIEW. RX MEDLINE=21634924; PubMed=11696554; DOI=10.1074/jbc.R100054200; RA Margolskee R.F.; RT "Molecular mechanisms of bitter and sweet taste transduction."; RL J. Biol. Chem. 277:1-4(2002). RN [6] RP REVIEW. RX MEDLINE=22469025; PubMed=12581520; DOI=10.1016/S0092-8674(03)00071-0; RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., RA Zuker C.S., Ryba N.J.; RT "Coding of sweet, bitter, and umami tastes: different receptor cells RT sharing similar signaling pathways."; RL Cell 112:293-301(2003). CC -!- FUNCTION: Gustducin-coupled cycloheximide receptor implicated in CC the perception of bitter compounds in the oral cavity and the CC gastrointestinal tract. Signals through PLCB2 and the calcium- CC regulated cation channel TRPM5. CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells CC of the tongue and palate epithelium and exclusively in gustducin- CC positive cells. Expressed in gastric and duodenal tissues. CC -!- POLYMORPHISM: Variations in Tas2r105 are associated with avoidance CC of cycloheximide at low concentrations. CC -!- DISRUPTION PHENOTYPE: Mice fail to avoid cycloheximide at low CC concentrations and show a lack of cycloheximide-induced action CC potentials in a principal nerve innervating taste receptor cells CC of the tongue. CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a CC single taste receptor cell. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF227147; AAF43920.1; -; Genomic_DNA. DR IPI; IPI00123398; -. DR RefSeq; NP_065247.1; NM_020501.1. DR UniGene; Mm.377131; -. DR ProteinModelPortal; Q9JKT4; -. DR STRING; Q9JKT4; -. DR PRIDE; Q9JKT4; -. DR Ensembl; ENSMUST00000053652; ENSMUSP00000058006; ENSMUSG00000051153. DR GeneID; 57252; -. DR KEGG; mmu:57252; -. DR CTD; 57252; -. DR MGI; MGI:2681195; Tas2r105. DR eggNOG; NOG28890; -. DR GeneTree; ENSGT00560000076963; -. DR HOGENOM; HBG505422; -. DR HOVERGEN; HBG060698; -. DR InParanoid; Q9JKT4; -. DR KO; K08474; -. DR OMA; ATSRIFI; -. DR OrthoDB; EOG4NZTTR; -. DR NextBio; 313539; -. DR ArrayExpress; Q9JKT4; -. DR Bgee; Q9JKT4; -. DR CleanEx; MM_TAS2R105; -. DR Genevestigator; Q9JKT4; -. DR GermOnline; ENSMUSG00000051153; Mus musculus. DR GO; GO:0016021; C:integral to membrane; NAS:UniProtKB. DR GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB. DR GO; GO:0050913; P:sensory perception of bitter taste; IMP:MGI. DR InterPro; IPR007960; TAS2_rcpt. DR Pfam; PF05296; TAS2R; 1. PE 1: Evidence at protein level; KW Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Reference proteome; Sensory transduction; Taste; Transducer; KW Transmembrane; Transmembrane helix. FT CHAIN 1 300 Taste receptor type 2 member 105. FT /FTId=PRO_0000082359. FT TOPO_DOM 1 7 Extracellular (Potential). FT TRANSMEM 8 28 Helical; Name=1; (Potential). FT TOPO_DOM 29 43 Cytoplasmic (Potential). FT TRANSMEM 44 64 Helical; Name=2; (Potential). FT TOPO_DOM 65 87 Extracellular (Potential). FT TRANSMEM 88 108 Helical; Name=3; (Potential). FT TOPO_DOM 109 128 Cytoplasmic (Potential). FT TRANSMEM 129 149 Helical; Name=4; (Potential). FT TOPO_DOM 150 181 Extracellular (Potential). FT TRANSMEM 182 202 Helical; Name=5; (Potential). FT TOPO_DOM 203 233 Cytoplasmic (Potential). FT TRANSMEM 234 254 Helical; Name=6; (Potential). FT TOPO_DOM 255 259 Extracellular (Potential). FT TRANSMEM 260 280 Helical; Name=7; (Potential). FT TOPO_DOM 281 300 Cytoplasmic (Potential). FT CARBOHYD 161 161 N-linked (GlcNAc...) (Potential). FT VARIANT 44 44 T -> I (in strain: BALB/c, C3H/He, CBA/Ca FT and DBA/2J). FT VARIANT 155 155 G -> D (in strain: BALB/c, C3H/He, CBA/Ca FT and DBA/2J). FT VARIANT 294 294 L -> R (in strain: BALB/c, C3H/He, CBA/Ca FT and DBA/2J). SQ SEQUENCE 300 AA; 34416 MW; 92AD449C68FB85EB CRC64; MLSAAEGILL SIATVEAGLG VLGNTFIALV NCMDWAKNNK LSMTGFLLIG LATSRIFIVW LLTLDAYAKL FYPSKYFSSS LIEIISYIWM TVNHLTVWFA TSLSIFYFLK IANFSDCVFL WLKRRTDKAF VFLLGCLLTS WVISFSFVVK VMKDGKVNHR NRTSEMYWEK RQFTINYVFL NIGVISLFMM TLTACFLLIM SLWRHSRQMQ SGVSGFRDLN TEAHVKAIKF LISFIILFVL YFIGVSIEII CIFIPENKLL FIFGFTTASI YPCCHSFILI LSNSQLKQAF VKVLQGLKFF //