ID T2R05_MOUSE STANDARD; PRT; 300 AA. AC Q9JKT4; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 07-FEB-2006 (Rel. 49, Last annotation update) DE Taste receptor type 2 member 105 (T2R105) (T2R5) (T2R9). GN Name=Tas2r105; Synonyms=Tas2r5, Tas2r9; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TOPOLOGY. RC STRAIN=129/SvJ; RX MEDLINE=20222571; PubMed=10761934; DOI=10.1016/S0092-8674(00)80705-9; RA Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., RA Zuker C.S.; RT "A novel family of mammalian taste receptors."; RL Cell 100:693-702(2000). RN [2] RP CHARACTERIZATION. RX MEDLINE=20222572; PubMed=10761935; DOI=10.1016/S0092-8674(00)80706-0; RA Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., RA Zuker C.S., Ryba N.J.P.; RT "T2Rs function as bitter taste receptors."; RL Cell 100:703-711(2000). RN [3] RP REVIEW. RX MEDLINE=22135574; PubMed=12139982; DOI=10.1016/S0959-4388(02)00345-8; RA Montmayeur J.-P., Matsunami H.; RT "Receptors for bitter and sweet taste."; RL Curr. Opin. Neurobiol. 12:366-371(2002). RN [4] RP REVIEW. RX MEDLINE=21634924; PubMed=11696554; DOI=10.1074/jbc.R100054200; RA Margolskee R.F.; RT "Molecular mechanisms of bitter and sweet taste transduction."; RL J. Biol. Chem. 277:1-4(2002). RN [5] RP REVIEW. RX MEDLINE=22469025; PubMed=12581520; DOI=10.1016/S0092-8674(03)00071-0; RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., RA Zuker C.S., Ryba N.J.; RT "Coding of sweet, bitter, and umami tastes: different receptor cells RT sharing similar signaling pathways."; RL Cell 112:293-301(2003). CC -!- FUNCTION: Receptor that may play a role in the perception of CC bitterness and is gustducin-linked. May play a role in sensing the CC chemical composition of the gastrointestinal content. The activity CC of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 CC activation and lead to the gating of TRPM5. Functions as a ligand CC for cyclohexamide. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells CC of the tongue and palate epithelium and exclusively in gustducin- CC positive cells. Expressed in gastric and duodenal tissues. CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited CC number of bitter compounds; individual taste cells can CC discriminate among bitter stimuli. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family. CC -!- CAUTION: This protein was previously referred to T2R5 or T2R9 but CC is now considered to be an ortholog of rat Tas2r105. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF227147; AAF43920.1; -; Genomic_DNA. DR Ensembl; ENSMUSG00000051153; Mus musculus. DR MGI; MGI:2681195; Tas2r105. DR GO; GO:0016021; C:integral to membrane; NAS. DR GO; GO:0008527; F:taste receptor activity; TAS. DR InterPro; IPR007960; TAS2_recept. DR PANTHER; PTHR11394; TAS2_recept; 1. DR Pfam; PF05296; TAS2R; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Sensory transduction; Taste; Transducer; Transmembrane. FT TOPO_DOM 1 7 Extracellular (Potential). FT TRANSMEM 8 28 1 (Potential). FT TOPO_DOM 29 43 Cytoplasmic (Potential). FT TRANSMEM 44 64 2 (Potential). FT TOPO_DOM 65 87 Extracellular (Potential). FT TRANSMEM 88 108 3 (Potential). FT TOPO_DOM 109 128 Cytoplasmic (Potential). FT TRANSMEM 129 149 4 (Potential). FT TOPO_DOM 150 181 Extracellular (Potential). FT TRANSMEM 182 202 5 (Potential). FT TOPO_DOM 203 233 Cytoplasmic (Potential). FT TRANSMEM 234 254 6 (Potential). FT TOPO_DOM 255 259 Extracellular (Potential). FT TRANSMEM 260 280 7 (Potential). FT TOPO_DOM 281 300 Cytoplasmic (Potential). FT CARBOHYD 161 161 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 300 AA; 34416 MW; 92AD449C68FB85EB CRC64; MLSAAEGILL SIATVEAGLG VLGNTFIALV NCMDWAKNNK LSMTGFLLIG LATSRIFIVW LLTLDAYAKL FYPSKYFSSS LIEIISYIWM TVNHLTVWFA TSLSIFYFLK IANFSDCVFL WLKRRTDKAF VFLLGCLLTS WVISFSFVVK VMKDGKVNHR NRTSEMYWEK RQFTINYVFL NIGVISLFMM TLTACFLLIM SLWRHSRQMQ SGVSGFRDLN TEAHVKAIKF LISFIILFVL YFIGVSIEII CIFIPENKLL FIFGFTTASI YPCCHSFILI LSNSQLKQAF VKVLQGLKFF //