ID TR105_MOUSE Reviewed; 300 AA.
AC Q9JKT4;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 07-JUN-2017, entry version 108.
DE RecName: Full=Taste receptor type 2 member 105;
DE Short=T2R105;
DE AltName: Full=Taste receptor type 2 member 5;
DE Short=T2R5;
DE AltName: Full=Taste receptor type 2 member 9;
DE Short=T2R9;
GN Name=Tas2r105; Synonyms=Tas2r5, Tas2r9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TOPOLOGY.
RC STRAIN=129/SvJ;
RX PubMed=10761934; DOI=10.1016/S0092-8674(00)80705-9;
RA Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA Zuker C.S.;
RT "A novel family of mammalian taste receptors.";
RL Cell 100:693-702(2000).
RN [2]
RP FUNCTION, VARIANTS ILE-44; ASP-155 AND ARG-294, AND POLYMORPHISM.
RX PubMed=10761935; DOI=10.1016/S0092-8674(00)80706-0;
RA Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
RA Zuker C.S., Ryba N.J.P.;
RT "T2Rs function as bitter taste receptors.";
RL Cell 100:703-711(2000).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15759003; DOI=10.1038/nature03352;
RA Mueller K.L., Hoon M.A., Erlenbach I., Chandrashekar J., Zuker C.S.,
RA Ryba N.J.;
RT "The receptors and coding logic for bitter taste.";
RL Nature 434:225-229(2005).
RN [4]
RP REVIEW.
RX PubMed=12139982; DOI=10.1016/S0959-4388(02)00345-8;
RA Montmayeur J.-P., Matsunami H.;
RT "Receptors for bitter and sweet taste.";
RL Curr. Opin. Neurobiol. 12:366-371(2002).
RN [5]
RP REVIEW.
RX PubMed=11696554; DOI=10.1074/jbc.R100054200;
RA Margolskee R.F.;
RT "Molecular mechanisms of bitter and sweet taste transduction.";
RL J. Biol. Chem. 277:1-4(2002).
RN [6]
RP REVIEW.
RX PubMed=12581520; DOI=10.1016/S0092-8674(03)00071-0;
RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA Zuker C.S., Ryba N.J.;
RT "Coding of sweet, bitter, and umami tastes: different receptor cells
RT sharing similar signaling pathways.";
RL Cell 112:293-301(2003).
CC -!- FUNCTION: Gustducin-coupled cycloheximide receptor implicated in
CC the perception of bitter compounds in the oral cavity and the
CC gastrointestinal tract. Signals through PLCB2 and the calcium-
CC regulated cation channel TRPM5. {ECO:0000269|PubMed:10761935,
CC ECO:0000269|PubMed:15759003}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells
CC of the tongue and palate epithelium and exclusively in gustducin-
CC positive cells. Expressed in gastric and duodenal tissues.
CC -!- POLYMORPHISM: Variations in Tas2r105 are associated with avoidance
CC of cycloheximide at low concentrations.
CC {ECO:0000269|PubMed:10761935}.
CC -!- DISRUPTION PHENOTYPE: Mice fail to avoid cycloheximide at low
CC concentrations and show a lack of cycloheximide-induced action
CC potentials in a principal nerve innervating taste receptor cells
CC of the tongue. {ECO:0000269|PubMed:15759003}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a
CC single taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AF227147; AAF43920.1; -; Genomic_DNA.
DR CCDS; CCDS20612.1; -.
DR RefSeq; NP_065247.1; NM_020501.1.
DR UniGene; Mm.377131; -.
DR ProteinModelPortal; Q9JKT4; -.
DR STRING; 10090.ENSMUSP00000058006; -.
DR PaxDb; Q9JKT4; -.
DR PRIDE; Q9JKT4; -.
DR Ensembl; ENSMUST00000053652; ENSMUSP00000058006; ENSMUSG00000051153.
DR GeneID; 57252; -.
DR KEGG; mmu:57252; -.
DR UCSC; uc009eiz.1; mouse.
DR CTD; 57252; -.
DR MGI; MGI:2681195; Tas2r105.
DR eggNOG; ENOG410IMNH; Eukaryota.
DR eggNOG; ENOG410Z4AM; LUCA.
DR GeneTree; ENSGT00760000119096; -.
DR HOGENOM; HOG000234595; -.
DR HOVERGEN; HBG060698; -.
DR InParanoid; Q9JKT4; -.
DR KO; K08474; -.
DR OMA; IANYSHC; -.
DR OrthoDB; EOG091G0KU9; -.
DR PhylomeDB; Q9JKT4; -.
DR TreeFam; TF335891; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR PRO; PR:Q9JKT4; -.
DR Proteomes; UP000000589; Chromosome 6.
DR Bgee; ENSMUSG00000051153; -.
DR CleanEx; MM_TAS2R105; -.
DR ExpressionAtlas; Q9JKT4; differential.
DR Genevisible; Q9JKT4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR GO; GO:0050913; P:sensory perception of bitter taste; IMP:MGI.
DR InterPro; IPR007960; T2R.
DR PANTHER; PTHR11394; PTHR11394; 1.
DR Pfam; PF05296; TAS2R; 1.
PE 1: Evidence at protein level;
KW Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Sensory transduction; Taste; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 300 Taste receptor type 2 member 105.
FT /FTId=PRO_0000082359.
FT TOPO_DOM 1 7 Extracellular. {ECO:0000255}.
FT TRANSMEM 8 28 Helical; Name=1. {ECO:0000255}.
FT TOPO_DOM 29 43 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 44 64 Helical; Name=2. {ECO:0000255}.
FT TOPO_DOM 65 87 Extracellular. {ECO:0000255}.
FT TRANSMEM 88 108 Helical; Name=3. {ECO:0000255}.
FT TOPO_DOM 109 128 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 129 149 Helical; Name=4. {ECO:0000255}.
FT TOPO_DOM 150 181 Extracellular. {ECO:0000255}.
FT TRANSMEM 182 202 Helical; Name=5. {ECO:0000255}.
FT TOPO_DOM 203 233 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 234 254 Helical; Name=6. {ECO:0000255}.
FT TOPO_DOM 255 259 Extracellular. {ECO:0000255}.
FT TRANSMEM 260 280 Helical; Name=7. {ECO:0000255}.
FT TOPO_DOM 281 300 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 161 161 N-linked (GlcNAc...) asparagine.
FT {ECO:0000255}.
FT VARIANT 44 44 T -> I (in strain: BALB/c, C3H/He, CBA/Ca
FT and DBA/2J).
FT {ECO:0000269|PubMed:10761935}.
FT VARIANT 155 155 G -> D (in strain: BALB/c, C3H/He, CBA/Ca
FT and DBA/2J).
FT {ECO:0000269|PubMed:10761935}.
FT VARIANT 294 294 L -> R (in strain: BALB/c, C3H/He, CBA/Ca
FT and DBA/2J).
FT {ECO:0000269|PubMed:10761935}.
SQ SEQUENCE 300 AA; 34416 MW; 92AD449C68FB85EB CRC64;
MLSAAEGILL SIATVEAGLG VLGNTFIALV NCMDWAKNNK LSMTGFLLIG LATSRIFIVW
LLTLDAYAKL FYPSKYFSSS LIEIISYIWM TVNHLTVWFA TSLSIFYFLK IANFSDCVFL
WLKRRTDKAF VFLLGCLLTS WVISFSFVVK VMKDGKVNHR NRTSEMYWEK RQFTINYVFL
NIGVISLFMM TLTACFLLIM SLWRHSRQMQ SGVSGFRDLN TEAHVKAIKF LISFIILFVL
YFIGVSIEII CIFIPENKLL FIFGFTTASI YPCCHSFILI LSNSQLKQAF VKVLQGLKFF
//