ID UBQL1_RAT STANDARD; PRT; 582 AA. AC Q9JJP9; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE Ubiquilin-1 (Protein linking IAP with cytoskeleton-1) (PLIC-1). GN Name=Ubqln1; Synonyms=Da41, Plic1; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH NBL1. RX PubMed=9303440; RA Ozaki T., Hishiki T., Toyama Y., Yuasa S., Nakagawara A., Sakiyama S.; RT "Identification of a new cellular protein that can interact RT specifically with DAN."; RL DNA Cell Biol. 16:985-991(1997). RN [2] RP INTERACTIONS WITH GABRA1; GABRA2; GABRA3; GABRA6; GABRB1; GABRB2 AND RP GABRB3, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RX PubMed=11528422; DOI=10.1038/nn0901-908; RA Bedford F.K., Kittler J.T., Muller E., Thomas P., Uren J.M., Merlo D., RA Wisden W., Triller A., Smart T.G., Moss S.J.; RT "GABA(A) receptor cell surface number and subunit stability are RT regulated by the ubiquitin-like protein Plic-1."; RL Nat. Neurosci. 4:908-916(2001). RN [3] RP X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) OF 450-458 IN COMPLEX WITH MHC RP I. RX PubMed=12470953; DOI=10.1016/S0022-2836(02)01095-1; RA Rudolph M.G., Stevens J., Speir J.A., Trowsdale J., Butcher G.W., RA Joly E., Wilson I.A.; RT "Crystal structures of two rat MHC class Ia (RT1-A) molecules that are RT associated differentially with peptide transporter alleles TAP-A and RT TAP-B."; RL J. Mol. Biol. 324:975-990(2002). CC -!- FUNCTION: Links CD47 to the cytoskeleton. Promotes the surface CC expression of GABA-A receptors. Promotes the accumulation of CC uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has CC no effect on PSEN1 and PSEN2 degradation (By similarity). CC -!- SUBUNIT: Binds CD47, UBE3A, BTRC, P4HB, FRAP1, PSEN1 and PSEN2. CC Interacts with the proteasome 19S subunit (By similarity). Binds CC NBL1, GABRA1, GABRA2, GABRA3, GABRA6, GABRB1, GABRB2 and GABRB3. CC -!- SUBCELLULAR LOCATION: Nuclear (By similarity) and cytoplasmic. CC Detected in neuronal processes and at synapses. CC -!- SIMILARITY: Contains 1 UBA domain. CC -!- SIMILARITY: Contains 1 ubiquitin-like domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D87950; BAA92267.1; -; mRNA. DR PDB; 1KJV; X-ray; -. DR SMR; Q9JJP9; 1-98. DR RGD; 620745; Ubqln1. DR InterPro; IPR006636; STI1_HS_bd. DR InterPro; IPR000449; UBA. DR InterPro; IPR000626; Ubiquitin. DR Pfam; PF00627; UBA; 1. DR Pfam; PF00240; ubiquitin; 1. DR SMART; SM00727; STI1; 2. DR SMART; SM00165; UBA; 1. DR SMART; SM00213; UBQ; 1. DR PROSITE; PS50030; UBA; 1. DR PROSITE; PS00299; UBIQUITIN_1; FALSE_NEG. DR PROSITE; PS50053; UBIQUITIN_2; 1. KW 3D-structure; Nuclear protein; Phosphorylation. FT DOMAIN 28 102 Ubiquitin-like. FT DOMAIN 539 579 UBA. FT COMPBIAS 372 546 Gln-rich. SQ SEQUENCE 582 AA; 62072 MW; 6651E95B09071E5B CRC64; MAESAESGGP PGAQDSAADS GPAEPKIMKV TVKTPKEKEE FAVPENSSVQ QFKEEISKRF KSHIDQLVLI FAGKILKDQD TLSQHGIHDG LTVHLVIKTQ NRPQDNSAQQ TNTTGNSVTS SPAPDSNPTS GPAANSSFGL GGLGGLAGLS SLGLNTTNFS ELQSQMQRQL LSNPEMMVQI MENPFVQSML SNPDLMRQLI MANPQMQQLI QRNPEISHML NNPNIMRQTL ELARNPAMMQ EMMRNQERDL SNLESIPGGY NALRRMYTDI QEPMLNAAQE QFGGNPFASL VSSPSSAEGT QPSRTENRDP LPNPWAPQTP QSSPASGSTG STTNTVSTSA GNATSTPAGQ GTSGPNLVPG AGASMFNTPG MQSLLQQITE NPQLMQNMLS APYMRSMMQS LSQNPDLAAQ MMLNNPLFAG NPQLQEQMRQ QLPTFLQQMQ NPDTLSAMSN PRAMQALLQI QQGLQTLATE APGLIPGFTP GLAAGNSGGP AGTTAPSTAP GEDTNPQGGA AEPGHQQFIQ QMLQALAGVN PQLQSPEVRF QQQLEQLSAM GFLNREANLQ ALIATGGDIN AAIERLLGSQ PS //