ID Q9IP55 PRELIMINARY; PRT; 450 AA. AC Q9IP55; DT 01-OCT-2000 (TrEMBLrel. 15, Created) DT 01-OCT-2000 (TrEMBLrel. 15, Last sequence update) DT 01-JUN-2003 (TrEMBLrel. 24, Last annotation update) DE Neuraminidase subtype 1. OS Influenza A virus (A/Hong Kong/485/97(H5N1)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A; H5N1 subtype. OX NCBI_TaxID=132612; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=A/Hong Kong/485/97; RX MEDLINE=20231940; PubMed=10769072; RA Hiromoto Y., Yamazaki Y., Fukushima T., Saito T., Lindstrom S.E., RA Omoe K., Nerome R., Lim W., Sugita S., Nerome K.; RT "Evolutionary characterization of the six internal genes of H5N1 human RT influenza A virus."; RL J. Gen. Virol. 81:1293-1303(2000). CC -!- FUNCTION: Removes the terminal sialic acid from carbohydrate side CC chains of the host cell surface proteins and from the viral CC envelope. Such a reaction prevents self-aggregation and facilitate CC the mobility of the virus to and from the site of infection (By CC similarity). CC -!- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, CC alpha-(2->8)-glycosidic linkages of terminal sialic residues in CC oligosaccharides, glycoproteins, glycolipids, colominic acid and CC synthetic substrates. CC -!- SUBUNIT: Homotetramer (By similarity). CC -!- SUBCELLULAR LOCATION: Viral membrane. Forms a mushroom-shaped CC spike on the surface of the virion (By similarity). CC -!- SIMILARITY: Belongs to family 34 of glycosyl hydrolases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF084274; AAF74324.1; -. DR HSSP; P03472; 1F8E. DR GO; GO:0016021; C:integral to membrane; IEA. DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA. DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA. DR GO; GO:0005975; P:carbohydrate metabolism; IEA. DR InterPro; IPR001860; Glyco_hydro_34. DR InterPro; IPR011040; Sialidase. DR Pfam; PF00064; Neur; 1. DR ProDom; PD000431; Glyco_hydro_34; 1. KW Glycoprotein; Glycosidase; Hydrolase; Transmembrane. SQ SEQUENCE 450 AA; 49534 MW; E9CA5A0D59E7C8F3 CRC64; MNPNQKIITI GSICMVVGII SLMLQIGNII SVWVSHIIQT WHPNQPEPCN QSINFYTEQA AASVTLAGNS SLCPISGWAI YSKDNSIRIG SKGDVFVIRE PFISCSHLEC RTFFLTQGAL LNDKHSNGTV KDRSPYRTLM SCPVGEAPSP YNSRFESVAW SASACHDGIS WLTIGISGPD NGAVAVLKYN GIITDTIKSW RNNILRTQES ECACVNGSCF TVMTDGPSNE QASYKIFKIE KGRVVKSVEL NAPNYHYEEC SCYPDAGEIT CVCRDNWHGS NRPWVSFNQN LEYQIGYICS GVFGDSPRPN DGTGSCGPVS LNGAYGVKGF SFKYGNGVWI GRTKSTSSRS GFEMIWDPNG WTETDSSFSL KQDIIAITDW SGYSGSFIQH PELTGLNCMR PCFWVELIRG RPKEKTIWTS GSSVSFCGVN SDTMGWSWPD GAELPFTIDK //