ID ADEN_ADEF1 Reviewed; 204 AA. AC Q9IIH4; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 10-JUN-2008, entry version 26. DE Adenain (EC 3.4.22.39) (Endoprotease) (Late L3 23 kDa protein). OS Frog adenovirus 1 (FrAdV-1). OC Viruses; dsDNA viruses, no RNA stage; Adenoviridae; Siadenovirus. OX NCBI_TaxID=114102; OH NCBI_TaxID=8404; Rana pipiens (Northern leopard frog). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Isolate ATCC VR-896; RA Davison A.J., Wright K.M., Harrach B.; RT "Phylogenetic position of an amphibian adenovirus."; RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Thiol protease cleaving specific Gly-Ala peptides in a CC number of viral precursor proteins (terminal, IIIa, VI, VII, VIII, CC IIa and mu) which are required for virion maturation. Also cleaves CC host cells cytoskeletal keratins K7 and K18. CC -!- CATALYTIC ACTIVITY: Cleaves proteins of the adenovirus and its CC host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-|-Xaa- and CC -Yaa-Xaa-Gly-Xaa-|-Gly- (in which Yaa is Met, Ile or Leu, and Xaa CC is any amino acid). CC -!- SIMILARITY: Belongs to the peptidase C5 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF224336; AAF86933.1; -; Genomic_DNA. DR RefSeq; NP_062444.1; -. DR HSSP; P03252; 1AVP. DR MEROPS; C05.001; -. DR GeneID; 1732705; -. DR InterPro; IPR000855; Peptidase_C5. DR Gene3D; G3DSA:3.40.395.10; Peptidase_C5; 1. DR Pfam; PF00770; Peptidase_C5; 1. DR PIRSF; PIRSF001218; Protease_ADV; 1. DR PRINTS; PR00703; ADVENDOPTASE. DR ProDom; PD003705; Peptidase_C5; 1. PE 3: Inferred from homology; KW Hydrolase; Late protein; Protease; Thiol protease. FT CHAIN 1 204 Adenain. FT /FTId=PRO_0000218042. FT ACT_SITE 54 54 By similarity. FT ACT_SITE 71 71 By similarity. FT ACT_SITE 121 121 By similarity. SQ SEQUENCE 204 AA; 23222 MW; 91DC0B01544577A5 CRC64; MGTSGADLEN IVLSLGLHSG FLGIFDKHFP GFLNVNKPSF AIVNTGDIIQ GGLHWIAFAF DNVTSTFFMF DPFGWSDMEL YRKYEFQYHR ILKSTALTKP SRCIKLVKSK EAVQCTCSAA CGLFCCLFLA SFYHYPTFPM RGNPIIDLVD GIPPTKLHSS YGIYLTHCNQ KKLIAWLLSN SAYFRKNAML MIHNTRLYYL YTHL //