ID Q9IB44_DANRE Unreviewed; 398 AA. AC Q9IB44; DT 01-OCT-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2000, sequence version 1. DT 02-OCT-2024, entry version 148. DE RecName: Full=G2/mitotic-specific cyclin-B1 {ECO:0000256|ARBA:ARBA00035702}; GN Name=ccnb1 {ECO:0000313|EMBL:AAI53627.1, GN ECO:0000313|RefSeq:NP_571588.1, ECO:0000313|ZFIN:ZDB-GENE-000406-10}; GN Synonyms=cb267 {ECO:0000313|RefSeq:NP_571588.1}, ccnb GN {ECO:0000313|RefSeq:NP_571588.1}, cycb GN {ECO:0000313|RefSeq:NP_571588.1}, cycb1 GN {ECO:0000313|RefSeq:NP_571588.1}, wu:fa19g04 GN {ECO:0000313|RefSeq:NP_571588.1}, wu:fb16d01 GN {ECO:0000313|RefSeq:NP_571588.1}, wu:fb16e07 GN {ECO:0000313|RefSeq:NP_571588.1}, wu:fi21c01 GN {ECO:0000313|RefSeq:NP_571588.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:BAA92876.1}; RN [1] {ECO:0000313|RefSeq:NP_571588.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=9331337; DOI=10.1006/dbio.1997.8673; RA Kondo T., Yanagawa T., Yoshida N., Yamashita M.; RT "Introduction of cyclin B induces activation of the maturation-promoting RT factor and breakdown of germinal vesicle in growing zebrafish oocytes RT unresponsive to the maturation-inducing hormone."; RL Dev. Biol. 190:142-152(1997). RN [2] {ECO:0000313|RefSeq:NP_571588.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=10727871; DOI=10.1016/S0925-4773(00)00247-1; RA Howley C., Ho R.K.; RT "mRNA localization patterns in zebrafish oocytes."; RL Mech. Dev. 92:305-309(2000). RN [3] {ECO:0000313|EMBL:AAP47013.1} RP NUCLEOTIDE SEQUENCE. RA Bauer M.P., Goetz F.W.; RT "The isolation and characterization of cyclin B from the zebrafish."; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|RefSeq:NP_571588.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11150242; RA Kondo T., Kotani T., Yamashita M.; RT "Dispersion of cyclin B mRNA aggregation is coupled with translational RT activation of the mRNA during zebrafish oocyte maturation."; RL Dev. Biol. 229:421-431(2001). RN [5] {ECO:0000313|EMBL:BAA92876.1, ECO:0000313|RefSeq:NP_571588.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Ovary {ECO:0000313|EMBL:BAA92876.1}; RX PubMed=11283000; DOI=10.1074/jbc.M010528200; RA Nakahata S., Katsu Y., Mita K., Inoue K., Nagahama Y., Yamashita M.; RT "Biochemical identification of Xenopus Pumilio as a sequence-specific RT cyclin B1 mRNA-binding protein that physically interacts with a Nanos RT homolog, Xcat-2, and a cytoplasmic polyadenylation element-binding RT protein."; RL J. Biol. Chem. 276:20945-20953(2001). RN [6] {ECO:0000313|RefSeq:NP_571588.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15256591; DOI=10.1073/pnas.0403929101; RA Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S., RA Hopkins N.; RT "Identification of 315 genes essential for early zebrafish development."; RL Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004). RN [7] {ECO:0000313|EMBL:AAI53627.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Activated eggs {ECO:0000313|EMBL:AAI53627.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [9] {ECO:0000313|RefSeq:NP_571588.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30327325; DOI=10.1242/dev.167023; RA Dingare C., Niedzwetzki A., Klemmt P.A., Godbersen S., Fuentes R., RA Mullins M.C., Lecaudey V.; RT "The Hippo pathway effector Taz is required for cell morphogenesis and RT fertilization in zebrafish."; RL Development 145:dev167023-dev167023(2018). RN [10] {ECO:0000313|RefSeq:NP_571588.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30410020; RA Anton K.A., Kajita M., Narumi R., Fujita Y., Tada M.; RT "Src-transformed cells hijack mitosis to extrude from the epithelium."; RL Nat. Commun. 9:4695-4695(2018). RN [11] {ECO:0000313|RefSeq:NP_571588.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30366296; RA Wang Y.Q., Li Y.W., Chen Q.L., Liu Z.H.; RT "Long-term exposure of xenoestrogens with environmental relevant RT concentrations disrupted spermatogenesis of zebrafish through altering sex RT hormone balance, stimulating germ cell proliferation, meiosis and enhancing RT apoptosis."; RL Environ. Pollut. 244:486-494(2019). RN [12] {ECO:0000313|RefSeq:NP_571588.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30606747; RA Mitra S., Sharma P., Kaur S., Khursheed M.A., Gupta S., Chaudhary M., RA Kurup A.J., Ramachandran R.; RT "Dual regulation of lin28a by Myc is necessary during zebrafish retina RT regeneration."; RL J. Cell Biol. 218:489-507(2019). RN [13] {ECO:0000313|RefSeq:NP_571588.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30608921; RA Yi X., Yu J., Ma C., Dong G., Shi W., Li H., Li L., Luo L., Sampath K., RA Ruan H., Huang H.; RT "The effector of Hippo signaling, Taz, is required for formation of the RT micropyle and fertilization in zebrafish."; RL PLoS Genet. 15:e1007408-e1007408(2019). RN [14] {ECO:0000313|RefSeq:NP_571588.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (JUN-2024) to UniProtKB. CC -!- FUNCTION: Essential for the control of the cell cycle at the G2/M CC (mitosis) transition. {ECO:0000256|ARBA:ARBA00003222}. CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily. CC {ECO:0000256|ARBA:ARBA00006955}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC153626; AAI53627.1; -; mRNA. DR EMBL; AF268043; AAP47013.1; -; mRNA. DR EMBL; AB040435; BAA92876.1; -; mRNA. DR RefSeq; NP_571588.1; NM_131513.1. DR GeneID; 58025; -. DR KEGG; dre:58025; -. DR AGR; ZFIN:ZDB-GENE-000406-10; -. DR CTD; 891; -. DR ZFIN; ZDB-GENE-000406-10; ccnb1. DR OrthoDB; 5474295at2759; -. DR Reactome; R-DRE-176408; Regulation of APC/C activators between G1/S and early anaphase. DR Reactome; R-DRE-176417; Phosphorylation of Emi1. DR Reactome; R-DRE-2299718; Condensation of Prophase Chromosomes. DR Reactome; R-DRE-2500257; Resolution of Sister Chromatid Cohesion. DR Reactome; R-DRE-2565942; Regulation of PLK1 Activity at G2/M Transition. DR Reactome; R-DRE-2995383; Initiation of Nuclear Envelope (NE) Reformation. DR Reactome; R-DRE-4419969; Depolymerization of the Nuclear Lamina. DR Reactome; R-DRE-6804114; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest. DR Reactome; R-DRE-69273; Cyclin A/B1/B2 associated events during G2/M transition. DR Reactome; R-DRE-69478; G2/M DNA replication checkpoint. DR Reactome; R-DRE-75035; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex. DR Proteomes; UP000000437; Chromosome 5. DR GO; GO:0005813; C:centrosome; IBA:GO_Central. DR GO; GO:0097125; C:cyclin B1-CDK1 complex; IBA:GO_Central. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central. DR GO; GO:0007080; P:mitotic metaphase chromosome alignment; IBA:GO_Central. DR GO; GO:0001556; P:oocyte maturation; IDA:ZFIN. DR CDD; cd20565; CYCLIN_CCNB1_rpt1; 1. DR CDD; cd20569; CYCLIN_CCNB1_rpt2; 1. DR Gene3D; 1.10.472.10; Cyclin-like; 2. DR InterPro; IPR048026; CCNB1_first_cyclin-box. DR InterPro; IPR039361; Cyclin. DR InterPro; IPR013763; Cyclin-like_dom. DR InterPro; IPR036915; Cyclin-like_sf. DR InterPro; IPR046965; Cyclin_A/B-like. DR InterPro; IPR004367; Cyclin_C-dom. DR InterPro; IPR006671; Cyclin_N. DR InterPro; IPR048258; Cyclins_cyclin-box. DR PANTHER; PTHR10177; CYCLINS; 1. DR PANTHER; PTHR10177:SF193; G2_MITOTIC-SPECIFIC CYCLIN-B1; 1. DR Pfam; PF02984; Cyclin_C; 1. DR Pfam; PF00134; Cyclin_N; 1. DR PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1. DR SMART; SM00385; CYCLIN; 2. DR SMART; SM01332; Cyclin_C; 1. DR SUPFAM; SSF47954; Cyclin-like; 2. DR PROSITE; PS00292; CYCLINS; 1. PE 1: Evidence at protein level; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306}; KW Cell division {ECO:0000256|ARBA:ARBA00022618}; KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383}; KW Mitosis {ECO:0000256|ARBA:ARBA00022776}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q9IB44}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. FT DOMAIN 174..258 FT /note="Cyclin-like" FT /evidence="ECO:0000259|SMART:SM00385" FT DOMAIN 267..385 FT /note="Cyclin C-terminal" FT /evidence="ECO:0000259|SMART:SM01332" FT DOMAIN 271..352 FT /note="Cyclin-like" FT /evidence="ECO:0000259|SMART:SM00385" FT REGION 1..25 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 76..101 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 8..22 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 398 AA; 44836 MW; 8A26971453F5907A CRC64; MMALRVTRNT RLASSENQNA LPGKAVVANK PGLRPRAALG EIGNNPQTRQ ALKKKEVKVA PAAEVVVEKA PVVQQPKKDS PKVQHGVKVV SEPSSPVPME TSGCASDDLC QAFSDVLLNI KDVDADDYDN PMLCSEYVKD IYLYLRQLET EQAVRPKYLA GKEVTGNMRA ILIDWLVQVQ IKFRLLQETM YMTVAIIDRF LQDHPVPKKQ LQLVGVTAMF IASKYEEMYP PEIADFAFVT DRAYTTSQIR EMEMKVLRVL NFGFGRPLPL QFLRRASKIG DVTAEHHTLA KYFLELTMVD YDMVHYPPSQ MASAAYALTL KVFNCGDWTP TLQHYMGYTE DELVPVMQHI AKNVVRVNEG LSKHLAVKNK YSSQKQMRIA TISQLKSSLI KDLAKQIS //