ID   ESR2_ICTPU     STANDARD;      PRT;   575 AA.
AC   Q9IAK1;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   16-OCT-2001 (Rel. 40, Last annotation update)
DE   Estrogen receptor beta (ER-beta).
GN   ESR2 OR NR3A2.
OS   Ictalurus punctatus (Channel catfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Ovary;
RX   MEDLINE=20218982; PubMed=10753576;
RA   Xia Z., Gale W.L., Chang X., Langenau D., Patino R., Maule A.G.,
RA   Densmore L.D.;
RT   "Phylogenetic sequence analysis, recombinant expression, and tissue
RT   distribution of a channel catfish estrogen receptor beta.";
RL   Gen. Comp. Endocrinol. 118:139-149(2000).
CC   -!- FUNCTION: Binds estrogens with an affinity similar to that of ER-
CC       alpha, and activates expression of reporter genes containing
CC       estrogen response elements (ERE) in an estrogen-dependent manner.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-
CC       alpha (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- TISSUE SPECIFICITY: Ovary and testis.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal steroid-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily.
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DR   EMBL; AF185568; AAF63157.1; -.
DR   HSSP; P03372; 1HCQ.
DR   InterPro; IPR000536; Hormone_rec_lig.
DR   InterPro; IPR001723; Stdhrmn_receptor.
DR   InterPro; IPR008946; Str_ncl_receptor.
DR   InterPro; IPR001628; Znf_C4steroid.
DR   Pfam; PF00104; hormone_rec; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_RECEPTOR; 1.
KW   Receptor; Transcription regulation; DNA-binding; Nuclear protein;
KW   Zinc-finger; Steroid-binding.
FT   DOMAIN        1    160       Modulating.
FT   DNA_BIND    161    226       Nuclear receptor-type.
FT   ZN_FING     161    181       C4-type.
FT   ZN_FING     197    221       C4-type.
FT   DOMAIN      227    575       STEROID-BINDING.
SQ   SEQUENCE   575 AA;  63907 MW;  E3863C6AB8EB824F CRC64;
     MSSSLSPTLQ TVNGMDQDEP LPLFPSHYPT ALGVDRGTVC IPSPYADNGH AEMSFCGPSA
     PENPAIAPPL SPSLFWSSHN PHAMPALPLH CPPALPYSEP HIHTAWVDTK PHTSGRHSSF
     LSRPKLFGKR PEDGDGDEAL DDDDPSSSSS GAVVKRDMHF CVVCHDYASG YHYGVWSCEG
     CKAFFKRSIQ GHNDYICPAT NQCTIDKNRR KSCQACRLRK CYEMGMMKCG ARRERCGYRA
     SRRTAPMRDG SARPVGVRGQ SQRLPHTPLH VSLSIPVSRA SAESGFSGLS PEQLVYCILE
     AEPPQIYLKQ QMKKPYTEST VMMSLTQLAD KELVLMISWA KKIPGFVELS LAHQVQLLEC
     CWLEVLMLGL MWRSIDHPGK LIFSLDLKLN RDEGNCVEGI MEIFDMLLAG SSRFRELKLQ
     KEEYVCLKAL ILLNSSMYMT SSACEKDLES RTKLLRLLDA VTDALVWAIS RTGLSTQQQS
     ARLAHLLMLL SHIRHLSNKG MEHLSSMKRK NVVLLYDLLL EMLDANMAQS RHVSTSVCTD
     PVTPATSPNT PLPPQLHSPV AHHVTQVNES QCSQE
//