ID   Q9HLW3_THEAC            Unreviewed;       869 AA.
AC   Q9HLW3;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   13-SEP-2023, entry version 113.
DE   SubName: Full=Probable aconitate hydratase {ECO:0000313|EMBL:CAC11259.1};
GN   OrderedLocusNames=Ta0112 {ECO:0000313|EMBL:CAC11259.1};
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075 {ECO:0000313|EMBL:CAC11259.1, ECO:0000313|Proteomes:UP000001024};
RN   [1] {ECO:0000313|EMBL:CAC11259.1, ECO:0000313|Proteomes:UP000001024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165
RC   {ECO:0000313|Proteomes:UP000001024};
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.L., Koretke K.K., Volker C.,
RA   Mewes H.W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC       {ECO:0000256|ARBA:ARBA00007185}.
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DR   EMBL; AL445063; CAC11259.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9HLW3; -.
DR   STRING; 273075.Ta0112; -.
DR   EnsemblBacteria; CAC11259; CAC11259; CAC11259.
DR   KEGG; tac:Ta0112; -.
DR   eggNOG; arCOG01697; Archaea.
DR   HOGENOM; CLU_013476_2_1_2; -.
DR   InParanoid; Q9HLW3; -.
DR   OMA; NGGIMQY; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01586; AcnA_IRP; 1.
DR   CDD; cd01580; AcnA_IRP_Swivel; 1.
DR   Gene3D; 6.10.190.10; -; 1.
DR   Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR   Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR   InterPro; IPR044137; AcnA_IRP_Swivel.
DR   InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR   InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR006249; Aconitase/IRP2.
DR   InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR   InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   NCBIfam; TIGR01341; aconitase_1; 1.
DR   PANTHER; PTHR11670; ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER; 1.
DR   PANTHER; PTHR11670:SF54; CITRATE HYDRO-LYASE; 1.
DR   Pfam; PF00330; Aconitase; 1.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   PRINTS; PR00415; ACONITASE.
DR   SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR   PROSITE; PS00450; ACONITASE_1; 1.
DR   PROSITE; PS01244; ACONITASE_2; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001024}.
FT   DOMAIN          50..545
FT                   /note="Aconitase/3-isopropylmalate dehydratase large
FT                   subunit alpha/beta/alpha"
FT                   /evidence="ECO:0000259|Pfam:PF00330"
FT   DOMAIN          672..798
FT                   /note="Aconitase A/isopropylmalate dehydratase small
FT                   subunit swivel"
FT                   /evidence="ECO:0000259|Pfam:PF00694"
SQ   SEQUENCE   869 AA;  96343 MW;  832C3FFB59338520 CRC64;
     MNGKKVYYYP LRKIFGEKVN SLPRSLRIIL ESMVRNLDGR SISDSDINAI LNWNAENVAD
     TEIRFKVSRV VMQDFTGVPA VVDLASMRDT VKNLGKDPEL INPQVRVDLV IDHSVQVDYY
     GETFALEKNE ELEFDRNMER YRFLKWAQKA FKNFKVIPPG TGIIHQVNLE YLAEVVFEGK
     KDGKDYAYFD SLVGTDSHTT MINGIGVLGW GVGGIEAEAA LLGQPITISL PEVIGVRIKG
     KMQPGVTATD VVLTVTEMLR KVNVVDKFVE FFGPSVKYLS VPERATISNM CPEFGATCAL
     FPIDDQTLQY LETTGRPKDH IDLIKKYLEA QGLFGEGAEP KYTRVIELDL STVKPSVAGP
     KLPQQRLDLD QVPASFLSTL EQNGGDRLVT LRKVPLKMKG QNLELSDGDI VIAAITSCTN
     TSNPYVMIAA GLLAKKAVEA GLKVNPKVKT SLAPGSRVVT DYLTESGLLS YLEKLGFYIV
     GYGCTTCIGN SGPLDQDLGN AIVNNNLSVV SVLSGNRNFE ARIHKDVKAN YLMSPPLVVA
     YALAGNITVN LNKDPIATVG GKKVYLKDIW PTNEEINEAV NKYVRKDMFE KRYGNITNER
     WEKIDAPSSP TYAWDPKSTY IRNPPFFENF RLDQEFTDFR IKGAYPLLVL GDSITTDHIS
     PAGSIAKDSP AAKYLIENGV KPEDFNSYGS RRGNHEVMMR GTFANVRIKN LMVKREGGYT
     LFVPENKEMS VYDAAMQYKK MGIPVVVIAG KEYGTGSSRD WAAKGTYLLG VKAVIAKSYE
     RIHRSNLVGM GVIPIEYEGF NPQDIDYTKT IDVDIGSIDP GSKAKITYTD KKGEKHTIDV
     RLRVDTPAES DYIKSGGILQ YSLKKILAS
//