ID   Q9HKZ3_THEAC            Unreviewed;       617 AA.
AC   Q9HKZ3;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 103.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   OrderedLocusNames=Ta0450 {ECO:0000313|EMBL:CAC11592.1};
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075 {ECO:0000313|EMBL:CAC11592.1, ECO:0000313|Proteomes:UP000001024};
RN   [1] {ECO:0000313|EMBL:CAC11592.1, ECO:0000313|Proteomes:UP000001024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165
RC   {ECO:0000313|Proteomes:UP000001024};
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.L., Koretke K.K., Volker C.,
RA   Mewes H.W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755}.
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DR   EMBL; AL445064; CAC11592.1; -; Genomic_DNA.
DR   RefSeq; WP_010900877.1; NC_002578.1.
DR   AlphaFoldDB; Q9HKZ3; -.
DR   STRING; 273075.gene:9571670; -.
DR   PaxDb; 273075-Ta0450; -.
DR   EnsemblBacteria; CAC11592; CAC11592; CAC11592.
DR   GeneID; 1456059; -.
DR   KEGG; tac:Ta0450; -.
DR   eggNOG; arCOG00329; Archaea.
DR   HOGENOM; CLU_000203_6_2_2; -.
DR   InParanoid; Q9HKZ3; -.
DR   OrthoDB; 8639at2157; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   CDD; cd05531; POLBc_B2; 1.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 2.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR   PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR   Pfam; PF00136; DNA_pol_B; 2.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022932};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001024};
KW   Transferase {ECO:0000256|ARBA:ARBA00022932}.
FT   DOMAIN          240..311
FT                   /note="DNA-directed DNA polymerase family B
FT                   multifunctional"
FT                   /evidence="ECO:0000259|Pfam:PF00136"
FT   DOMAIN          314..393
FT                   /note="DNA-directed DNA polymerase family B
FT                   multifunctional"
FT                   /evidence="ECO:0000259|Pfam:PF00136"
SQ   SEQUENCE   617 AA;  71401 MW;  EC0B5D886AAD1340 CRC64;
     MTLYEYDGSH VRKRVFQNTS WIFVTGDRYD IETLYDQLDS TRLKYEYSTM PDIYGYQDGI
     KIWVRPSHAR MVGEIIFSNI GYGRRYRVYN ADIDPVLRFM ASNGLSFFEM RSVYDPDPDL
     NVAMVDCSHG KCIVDGEAMG DGRIYDRLMD SHVIVYEGTE QFYRKLMALG IRARYYPGKS
     FTSYGQISYR DSYLDIADRI AINSRSFFYA ESGLSGIYEV SRISHLPPLY VSIVTPGTAV
     SSMELAEAVK KGMLVPFKKD DHENPKTKWE IMAKDRGGLI FQPLPGLYTD VYEIDFSSMY
     PSIIVRYDLT PGRISFLPEA LEGLLSRRLI YKKMDGESVV YHSRNVALKW LLLTSFGYTG
     YKNAKFGKIE VHERITELGR KALAEAIAVA HENGFEMIHG IVDSLWIRGS GSIERVVSEI
     SRRTRIDIVV SGHYHWIAFL PERDGTGSPS RYIGLDTSGK YKIRGLMIRR SDVPDLCKAF
     QMDALRVLSS CTDTRCILEK RREIMDLENY YLRNIRHFPR SYFMVSRKIT RRPDEYHVKN
     LTRSALDLCR DAEELSPGQM ISYYVVDEKR KIVDTDGENG IDYGYYRRCL TRALEEINFL
     FGKNCNIRRL EDFQSFQ
//