ID TM9S3_HUMAN Reviewed; 589 AA. AC Q9HD45; Q5TB57; Q6UWE7; Q9NWL8; Q9P0G9; Q9UHW8; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 27-APR-2001, sequence version 2. DT 23-FEB-2022, entry version 166. DE RecName: Full=Transmembrane 9 superfamily member 3; DE AltName: Full=EP70-P-iso; DE AltName: Full=SM-11044-binding protein; DE Flags: Precursor; GN Name=TM9SF3; Synonyms=SMBP; ORFNames=UNQ245/PRO282; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Warner S.J., Lomax M.I.; RT "Evolution of the TM9 super family of membrane spanning proteins."; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Adrenal gland; RA Gu Y., Peng Y., Li Y., Fu S., Gu J., Gu W., Jiang C., Yu Y., Han Z., RA Wang Y., Chen Z., Fu G.; RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 12-589. RC TISSUE=Skeletal muscle; RA Sugasawa T., Lenzen G., Simon S., Hidaka J., Cahen A., Guillaume J.L., RA Camoin L., Nahmias C., Strosberg A.D.; RT "The iodocyanopindolol and SM-11044 binding protein (SMBP) belongs to the RT emerging family of MP70 multispanning membrane proteins."; RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-589. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale effort to RT identify novel human secreted and transmembrane proteins: a bioinformatics RT assessment."; RL Genome Res. 13:2265-2270(2003). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 128-589. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [9] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-174. RC TISSUE=Liver; RX PubMed=19159218; DOI=10.1021/pr8008012; RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; RT "Glycoproteomics analysis of human liver tissue by combination of multiple RT enzyme digestion and hydrazide chemistry."; RL J. Proteome Res. 8:651-661(2009). RN [10] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-174. RC TISSUE=Leukemic T-cell; RX PubMed=19349973; DOI=10.1038/nbt.1532; RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., RA Schiess R., Aebersold R., Watts J.D.; RT "Mass-spectrometric identification and relative quantification of N-linked RT cell surface glycoproteins."; RL Nat. Biotechnol. 27:378-386(2009). RN [11] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAF67014.1; Type=Frameshift; Evidence={ECO:0000305}; CC Sequence=AAQ89178.1; Type=Frameshift; Evidence={ECO:0000305}; CC Sequence=BAA91362.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF269150; AAF98159.1; -; mRNA. DR EMBL; AF160213; AAF67014.1; ALT_FRAME; mRNA. DR EMBL; AL138765; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471066; EAW49972.1; -; Genomic_DNA. DR EMBL; CH471066; EAW49974.1; -; Genomic_DNA. DR EMBL; BC136788; AAI36789.1; -; mRNA. DR EMBL; BC136789; AAI36790.1; -; mRNA. DR EMBL; AF116347; AAF21983.1; -; mRNA. DR EMBL; AY358819; AAQ89178.1; ALT_FRAME; mRNA. DR EMBL; AK000756; BAA91362.1; ALT_INIT; mRNA. DR CCDS; CCDS7450.1; -. DR RefSeq; NP_064508.3; NM_020123.3. DR SMR; Q9HD45; -. DR BioGRID; 121219; 99. DR IntAct; Q9HD45; 29. DR MINT; Q9HD45; -. DR STRING; 9606.ENSP00000360184; -. DR GlyConnect; 1842; 33 N-Linked glycans (1 site). DR GlyGen; Q9HD45; 3 sites, 32 N-linked glycans (1 site), 1 O-linked glycan (1 site). DR iPTMnet; Q9HD45; -. DR PhosphoSitePlus; Q9HD45; -. DR SwissPalm; Q9HD45; -. DR BioMuta; TM9SF3; -. DR DMDM; 13878808; -. DR EPD; Q9HD45; -. DR jPOST; Q9HD45; -. DR MassIVE; Q9HD45; -. DR MaxQB; Q9HD45; -. DR PaxDb; Q9HD45; -. DR PeptideAtlas; Q9HD45; -. DR PRIDE; Q9HD45; -. DR ProteomicsDB; 81832; -. DR Antibodypedia; 50246; 88 antibodies from 19 providers. DR DNASU; 56889; -. DR Ensembl; ENST00000371142; ENSP00000360184; ENSG00000077147. DR GeneID; 56889; -. DR KEGG; hsa:56889; -. DR MANE-Select; ENST00000371142.9; ENSP00000360184.4; NM_020123.4; NP_064508.3. DR UCSC; uc001kmm.5; human. DR CTD; 56889; -. DR DisGeNET; 56889; -. DR GeneCards; TM9SF3; -. DR HGNC; HGNC:21529; TM9SF3. DR HPA; ENSG00000077147; Low tissue specificity. DR neXtProt; NX_Q9HD45; -. DR OpenTargets; ENSG00000077147; -. DR PharmGKB; PA144596264; -. DR VEuPathDB; HostDB:ENSG00000077147; -. DR eggNOG; KOG1277; Eukaryota. DR GeneTree; ENSGT00940000155493; -. DR HOGENOM; CLU_010714_0_2_1; -. DR InParanoid; Q9HD45; -. DR OMA; DEHDHLY; -. DR OrthoDB; 641127at2759; -. DR PhylomeDB; Q9HD45; -. DR TreeFam; TF314271; -. DR PathwayCommons; Q9HD45; -. DR SignaLink; Q9HD45; -. DR BioGRID-ORCS; 56889; 71 hits in 1050 CRISPR screens. DR ChiTaRS; TM9SF3; human. DR GenomeRNAi; 56889; -. DR Pharos; Q9HD45; Tbio. DR PRO; PR:Q9HD45; -. DR Proteomes; UP000005640; Chromosome 10. DR RNAct; Q9HD45; protein. DR Bgee; ENSG00000077147; Expressed in calcaneal tendon and 242 other tissues. DR ExpressionAtlas; Q9HD45; baseline and differential. DR Genevisible; Q9HD45; HS. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0072657; P:protein localization to membrane; IBA:GO_Central. DR InterPro; IPR004240; EMP70. DR PANTHER; PTHR10766; PTHR10766; 1. DR Pfam; PF02990; EMP70; 1. PE 1: Evidence at protein level; KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1..28 FT /evidence="ECO:0000255" FT CHAIN 29..589 FT /note="Transmembrane 9 superfamily member 3" FT /id="PRO_0000034369" FT TRANSMEM 224..244 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 294..314 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 328..348 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 360..380 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 389..409 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 449..469 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 482..502 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 519..539 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 551..571 FT /note="Helical" FT /evidence="ECO:0000255" FT CARBOHYD 174 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:19159218, FT ECO:0000269|PubMed:19349973" FT CARBOHYD 419 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CONFLICT 15 FT /note="Missing (in Ref. 2; AAF67014)" FT /evidence="ECO:0000305" FT CONFLICT 191 FT /note="M -> I (in Ref. 1; AAF98159)" FT /evidence="ECO:0000305" FT CONFLICT 210..218 FT /note="KYLDPSFFQ -> NILIVLFS (in Ref. 2; AAF67014)" FT /evidence="ECO:0000305" FT CONFLICT 232 FT /note="M -> T (in Ref. 8; BAA91362)" FT /evidence="ECO:0000305" FT CONFLICT 398 FT /note="V -> R (in Ref. 7; AAQ89178)" FT /evidence="ECO:0000305" FT CONFLICT 547 FT /note="F -> S (in Ref. 8; BAA91362)" FT /evidence="ECO:0000305" SQ SEQUENCE 589 AA; 67888 MW; E673D547A35BC4A7 CRC64; MRPLPGALGV AAAAALWLLL LLLPRTRADE HEHTYQDKEE VVLWMNTVGP YHNRQETYKY FSLPFCVGSK KSISHYHETL GEALQGVELE FSGLDIKFKD DVMPATYCEI DLDKEKRDAF VYAIKNHYWY QMYIDDLPIW GIVGEADENG EDYYLWTYKK LEIGFNGNRI VDVNLTSEGK VKLVPNTKIQ MSYSVKWKKS DVKFEDRFDK YLDPSFFQHR IHWFSIFNSF MMVIFLVGLV SMILMRTLRK DYARYSKEEE MDDMDRDLGD EYGWKQVHGD VFRPSSHPLI FSSLIGSGCQ IFAVSLIVII VAMIEDLYTE RGSMLSTAIF VYAATSPVNG YFGGSLYARQ GGRRWIKQMF IGAFLIPAMV CGTAFFINFI AIYYHASRAI PFGTMVAVCC ICFFVILPLN LVGTILGRNL SGQPNFPCRV NAVPRPIPEK KWFMEPAVIV CLGGILPFGS IFIEMYFIFT SFWAYKIYYV YGFMMLVLVI LCIVTVCVTI VCTYFLLNAE DYRWQWTSFL SAASTAIYVY MYSFYYYFFK TKMYGLFQTS FYFGYMAVFS TALGIMCGAI GYMGTSAFVR KIYTNVKID //