ID PREB_HUMAN STANDARD; PRT; 417 AA. AC Q9HCU5; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Prolactin regulatory element-binding protein. GN Name=PREB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=20380828; PubMed=10920239; RA Taylor Clelland C.L., Levy B., McKie J.M., Duncan A.M.V., RA Hirschhorn K., Bancroft C.; RT "Cloning and characterization of human PREB; a gene that maps to a RT genomic region associated with trisomy 2p syndrome."; RL Mamm. Genome 11:675-681(2000). CC -!- FUNCTION: Seems to be involved in the regulation of pituitary gene CC transcription. Bind to the prolactin gene (PRL) promoter and seems CC to activate transcription (By similarity). CC -!- SUBCELLULAR LOCATION: Nuclear (By similarity). CC -!- TISSUE SPECIFICITY: Ubiquitous. CC -!- SIMILARITY: Contains 3 WD repeats. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF226684; AAG01692.1; -. DR TRANSFAC; T05048; -. DR Genew; HGNC:9356; PREB. DR H-InvDB; HIX0001910; -. DR MIM; 606395; -. DR InterPro; IPR000008; C2. DR InterPro; IPR001680; WD40. DR InterPro; IPR011046; WD40_like. DR Pfam; PF00400; WD40; 2. DR PRINTS; PR00360; C2DOMAIN. DR SMART; SM00320; WD40; 4. DR PROSITE; PS00678; WD_REPEATS_1; FALSE_NEG. DR PROSITE; PS50082; WD_REPEATS_2; 1. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. KW Activator; DNA-binding; Nuclear protein; Repeat; KW Transcription regulation; WD repeat. FT REPEAT 152 191 WD 1. FT REPEAT 194 232 WD 2. FT REPEAT 298 337 WD 3. SQ SEQUENCE 417 AA; 45502 MW; 407B59C5C56E6698 CRC64; MGRRRAPELY RAPFPLYAFQ VDPSTGLLIA AGGGGAAKTG IKNGVHFLQL ELINGRLSAS LLHSHDTETR ATMNLALAGD ILAAGQDAHC QLLRFQAHQQ QGNKAEKAGS KEQGPRQRKG AAPAEKKCGA ETQHEGLELR VENLQAVQTD FSSDPLQKVV CFNHDNTLLA TGGTDGYVRV WKVPSLEKVL EFKAHEGEIE DLALGPDGKL VTVGRDLKAS VWQKDQLVTQ LHWQENGPTF SSTPYRYQAC RFGQVPDQPA GLRLFTVQIP HKRLRQPPPC YLTAWDGSNF LPLRTKSCGH EVVSCLDVSE SGTFLGLGTV TGSVAIYIAF SLQCLYYVRE AHGIVVTDVA FLPEKGRGPE LLGSHETALF SVAVDSRCQL HLLPSRRSVP VWLLLLLCVG LIIVTILLLQ SAFPGFL //