ID ZFP14_HUMAN Reviewed; 533 AA. AC Q9HCL3; A7MD23; DT 21-FEB-2002, integrated into UniProtKB/Swiss-Prot. DT 21-FEB-2002, sequence version 2. DT 03-MAY-2023, entry version 171. DE RecName: Full=Zinc finger protein 14 homolog; DE Short=Zfp-14; DE AltName: Full=Zinc finger protein 531; GN Name=ZFP14; Synonyms=KIAA1559, ZNF531; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=10997877; DOI=10.1093/dnares/7.4.271; RA Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. XVIII. The RT complete sequences of 100 new cDNA clones from brain which code for large RT proteins in vitro."; RL DNA Res. 7:273-281(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May be involved in transcriptional regulation. CC -!- INTERACTION: CC Q9HCL3; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-6381556, EBI-746778; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAB13385.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB046779; BAB13385.1; ALT_INIT; mRNA. DR EMBL; BC152446; AAI52447.1; -; mRNA. DR CCDS; CCDS33002.1; -. DR RefSeq; NP_065968.1; NM_020917.2. DR RefSeq; XP_016882527.1; XM_017027038.1. DR AlphaFoldDB; Q9HCL3; -. DR SMR; Q9HCL3; -. DR BioGRID; 121706; 6. DR IntAct; Q9HCL3; 7. DR MINT; Q9HCL3; -. DR STRING; 9606.ENSP00000270001; -. DR iPTMnet; Q9HCL3; -. DR PhosphoSitePlus; Q9HCL3; -. DR BioMuta; ZFP14; -. DR DMDM; 20140808; -. DR EPD; Q9HCL3; -. DR jPOST; Q9HCL3; -. DR MassIVE; Q9HCL3; -. DR MaxQB; Q9HCL3; -. DR PaxDb; Q9HCL3; -. DR PeptideAtlas; Q9HCL3; -. DR ProteomicsDB; 81753; -. DR Antibodypedia; 29750; 90 antibodies from 17 providers. DR DNASU; 57677; -. DR Ensembl; ENST00000270001.12; ENSP00000270001.6; ENSG00000142065.14. DR GeneID; 57677; -. DR KEGG; hsa:57677; -. DR MANE-Select; ENST00000270001.12; ENSP00000270001.6; NM_020917.3; NP_065968.1. DR UCSC; uc010eex.3; human. DR AGR; HGNC:29312; -. DR CTD; 57677; -. DR GeneCards; ZFP14; -. DR HGNC; HGNC:29312; ZFP14. DR HPA; ENSG00000142065; Low tissue specificity. DR MIM; 620163; gene. DR neXtProt; NX_Q9HCL3; -. DR OpenTargets; ENSG00000142065; -. DR PharmGKB; PA145147576; -. DR VEuPathDB; HostDB:ENSG00000142065; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000162016; -. DR HOGENOM; CLU_002678_44_0_1; -. DR InParanoid; Q9HCL3; -. DR OMA; YECVECW; -. DR OrthoDB; 3120634at2759; -. DR PhylomeDB; Q9HCL3; -. DR TreeFam; TF341817; -. DR PathwayCommons; Q9HCL3; -. DR Reactome; R-HSA-212436; Generic Transcription Pathway. DR SignaLink; Q9HCL3; -. DR BioGRID-ORCS; 57677; 27 hits in 1170 CRISPR screens. DR ChiTaRS; ZFP14; human. DR GenomeRNAi; 57677; -. DR Pharos; Q9HCL3; Tdark. DR PRO; PR:Q9HCL3; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; Q9HCL3; protein. DR Bgee; ENSG00000142065; Expressed in cortical plate and 143 other tissues. DR ExpressionAtlas; Q9HCL3; baseline and differential. DR Genevisible; Q9HCL3; HS. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro. DR CDD; cd07765; KRAB_A-box; 1. DR Gene3D; 6.10.140.140; -; 1. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 13. DR InterPro; IPR001909; KRAB. DR InterPro; IPR036051; KRAB_dom_sf. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR24377; IP01015P-RELATED; 1. DR PANTHER; PTHR24377:SF980; ZINC FINGER PROTEIN 420; 1. DR Pfam; PF01352; KRAB; 1. DR Pfam; PF00096; zf-C2H2; 12. DR Pfam; PF13912; zf-C2H2_6; 1. DR SMART; SM00349; KRAB; 1. DR SMART; SM00355; ZnF_C2H2; 13. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7. DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1. DR PROSITE; PS50805; KRAB; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13. PE 1: Evidence at protein level; KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; KW Transcription; Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1..533 FT /note="Zinc finger protein 14 homolog" FT /id="PRO_0000047285" FT DOMAIN 6..78 FT /note="KRAB" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119" FT ZN_FING 172..194 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 200..222 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 228..250 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 256..278 FT /note="C2H2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 284..306 FT /note="C2H2-type 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 312..334 FT /note="C2H2-type 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 340..362 FT /note="C2H2-type 7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 368..390 FT /note="C2H2-type 8" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 396..418 FT /note="C2H2-type 9" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 424..446 FT /note="C2H2-type 10" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 452..474 FT /note="C2H2-type 11" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 480..502 FT /note="C2H2-type 12" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 508..530 FT /note="C2H2-type 13" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" SQ SEQUENCE 533 AA; 63463 MW; E40EF5EC22A99F10 CRC64; MAHGSVTFRD VAIDFSQEEW EFLDPAQRDL YRDVMWENYS NFISLGPSIS KPDVITLLDE ERKEPGMVVR EGTRRYCPDL ESRYRTNTLS PEKDIYEIYS FQWDIMERIK SYSLQGSIFR NDWECKSKIE GEKEQQEGYF GQVKITSEKM TTYKRHNFLT EYQIVHNGEK VYECKECRKT FIRRSTLSQH LRIHTGEKPY KCKECGQAFR QRAHLIRHHK LHTGEKPYEC KECGKAFTVL QELTQHQRLH TGEKPYECKE CGKAFRVHQQ LARHQRIHTG EKPYECKDCG KTFRQCTHLT RHQRLHTAEK LYECKECGKA FVCGPDLRVH QKIHFGEKPY ECKECGKAFR ICQQLTVHQS IHTGEKPYEC KECGKTFRLR QQLVRHQRIH TREKPYECME CWKTFSSYSQ LISHQSIHIG ERPYECEECG KAFRLLSQLT QHQSIHTGEK PYECKECRKP FRLLSQLTQH QSIHTGEKPY ECKECGKAFR LYSFLTQHQR IHTGEKPYKC KECKKAFRQH SHLTQHQKIH NGI //