ID   CCNP_HUMAN              Reviewed;         307 AA.
AC   Q9H8S5; B4DX65;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   29-MAY-2024, entry version 147.
DE   RecName: Full=Cyclin-P {ECO:0000305};
DE   AltName: Full=Cyclin N-terminal domain-containing protein 2;
GN   Name=CCNP {ECO:0000312|HGNC:HGNC:25805}; Synonyms=CNTD2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Ovary, and Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=28860486; DOI=10.1038/s41598-017-10770-8;
RA   Gasa L., Sanchez-Botet A., Quandt E., Hernandez-Ortega S., Jimenez J.,
RA   Carrasco-Garcia M.A., Simonetti S., Kron S.J., Ribeiro M.P., Nadal E.,
RA   Villanueva A., Clotet J.;
RT   "A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic
RT   driver in lung cancer.";
RL   Sci. Rep. 7:10228-10228(2017).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=30087414; DOI=10.1038/s41598-018-30307-x;
RA   Sanchez-Botet A., Gasa L., Quandt E., Hernandez-Ortega S., Jimenez J.,
RA   Mezquita P., Carrasco-Garcia M.A., Kron S.J., Vidal A., Villanueva A.,
RA   Ribeiro M.P.C., Clotet J.;
RT   "The atypical cyclin CNTD2 promotes colon cancer cell proliferation and
RT   migration.";
RL   Sci. Rep. 8:11797-11797(2018).
CC   -!- FUNCTION: Seems to be involved in the regulation of proliferation and
CC       migration. {ECO:0000269|PubMed:28860486, ECO:0000269|PubMed:30087414}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28860486,
CC       ECO:0000269|PubMed:30087414}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9H8S5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9H8S5-2; Sequence=VSP_044165, VSP_044166, VSP_044167;
CC   -!- TISSUE SPECIFICITY: Expression is induced in lung and colon cancer
CC       cells. {ECO:0000269|PubMed:28860486, ECO:0000269|PubMed:30087414}.
CC   -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC       premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC       decay. {ECO:0000305}.
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DR   EMBL; AK023327; BAB14529.1; -; mRNA.
DR   EMBL; AK301833; BAG63277.1; -; mRNA.
DR   EMBL; AC118344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS12551.2; -. [Q9H8S5-1]
DR   RefSeq; NP_079153.2; NM_024877.3. [Q9H8S5-1]
DR   AlphaFoldDB; Q9H8S5; -.
DR   SMR; Q9H8S5; -.
DR   STRING; 9606.ENSP00000396755; -.
DR   iPTMnet; Q9H8S5; -.
DR   PhosphoSitePlus; Q9H8S5; -.
DR   BioMuta; CNTD2; -.
DR   DMDM; 408360026; -.
DR   MassIVE; Q9H8S5; -.
DR   PaxDb; 9606-ENSP00000396755; -.
DR   PeptideAtlas; Q9H8S5; -.
DR   Antibodypedia; 57311; 109 antibodies from 21 providers.
DR   DNASU; 79935; -.
DR   Ensembl; ENST00000221818.5; ENSP00000221818.1; ENSG00000105219.10. [Q9H8S5-2]
DR   Ensembl; ENST00000430325.7; ENSP00000396755.2; ENSG00000105219.10. [Q9H8S5-1]
DR   GeneID; 79935; -.
DR   KEGG; hsa:79935; -.
DR   MANE-Select; ENST00000430325.7; ENSP00000396755.2; NM_024877.4; NP_079153.2.
DR   UCSC; uc010xvi.2; human. [Q9H8S5-1]
DR   AGR; HGNC:25805; -.
DR   CTD; 79935; -.
DR   DisGeNET; 79935; -.
DR   GeneCards; CCNP; -.
DR   HGNC; HGNC:25805; CCNP.
DR   HPA; ENSG00000105219; Group enriched (brain, kidney, liver, pituitary gland).
DR   MIM; 620396; gene.
DR   neXtProt; NX_Q9H8S5; -.
DR   OpenTargets; ENSG00000105219; -.
DR   VEuPathDB; HostDB:ENSG00000105219; -.
DR   eggNOG; KOG0653; Eukaryota.
DR   GeneTree; ENSGT00920000149201; -.
DR   HOGENOM; CLU_060971_0_0_1; -.
DR   InParanoid; Q9H8S5; -.
DR   OrthoDB; 4661482at2759; -.
DR   PhylomeDB; Q9H8S5; -.
DR   TreeFam; TF342174; -.
DR   PathwayCommons; Q9H8S5; -.
DR   SignaLink; Q9H8S5; -.
DR   BioGRID-ORCS; 79935; 22 hits in 1139 CRISPR screens.
DR   ChiTaRS; CNTD2; human.
DR   GenomeRNAi; 79935; -.
DR   Pharos; Q9H8S5; Tbio.
DR   PRO; PR:Q9H8S5; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q9H8S5; Protein.
DR   Bgee; ENSG00000105219; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 117 other cell types or tissues.
DR   ExpressionAtlas; Q9H8S5; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0097124; C:cyclin A2-CDK2 complex; IEA:TreeGrafter.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   CDD; cd20542; CYCLIN_CNTD2; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 2.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like_dom.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177:SF257; CYCLIN-P; 1.
DR   PANTHER; PTHR10177; CYCLINS; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; Cyclin-like; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Nucleus; Reference proteome.
FT   CHAIN           1..307
FT                   /note="Cyclin-P"
FT                   /id="PRO_0000263704"
FT   DOMAIN          102..203
FT                   /note="Cyclin N-terminal"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          35..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         90..119
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_044165"
FT   VAR_SEQ         172..185
FT                   /note="PAFLCLLSADSFSR -> ETEVRNLGPFQGRE (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_044166"
FT   VAR_SEQ         186..307
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_044167"
SQ   SEQUENCE   307 AA;  33574 MW;  9A5E71ADCE0D63E0 CRC64;
     MLVRGRDQGS GSRLGPIVRR WAPRPSPLQS LAASLDAEPS SAAVPDGFPA GPTVSPRRLA
     RPPGLEEALS ALGLQGEREY AGDIFAEVMV CRVLPLRALP RAVTPEMRAL VVDWLVQVHE
     YLGLAGDTLY LAVHLLDSYL SAGRVRLHRL QLLGVACLFV ACKMEECVLP EPAFLCLLSA
     DSFSRAELLR AERRILSRLD FRLHHPGPLL CLGLLAALAG SSPQVMLLAT YFLELSLLEA
     EAAGWEPGRR AAAALSLAHR LLDGAGSRLQ PELYRCSLGG GSVWGHRSFR DLPSWSFLRS
     RRMRDNY
//