ID   SO5A1_HUMAN             Reviewed;         848 AA.
AC   Q9H2Y9; A4QPC2; B2RPF7; B3KMU7; E9PKK5; G3V1C0;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   02-JUN-2021, entry version 163.
DE   RecName: Full=Solute carrier organic anion transporter family member 5A1;
DE   AltName: Full=Organic anion transporter polypeptide-related protein 4;
DE            Short=OATP-RP4;
DE            Short=OATPRP4;
DE   AltName: Full=Solute carrier family 21 member 15;
GN   Name=SLCO5A1; Synonyms=OATP5A1, SLC21A15;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Wu Y., Hsiang B.H., Zhu Y., Yang W.-P., Kirchgessner T.G.;
RT   "Identification and characterization of novel human OATP family members.";
RL   Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   PHE-33.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9H2Y9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9H2Y9-2; Sequence=VSP_045498;
CC       Name=3;
CC         IsoId=Q9H2Y9-3; Sequence=VSP_045499, VSP_045500;
CC   -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC       {ECO:0000305}.
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DR   EMBL; AF205075; AAG42207.1; -; mRNA.
DR   EMBL; AK022760; BAG51109.1; -; mRNA.
DR   EMBL; AC024680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471068; EAW86957.1; -; Genomic_DNA.
DR   EMBL; CH471068; EAW86958.1; -; Genomic_DNA.
DR   EMBL; BC137424; AAI37425.1; -; mRNA.
DR   EMBL; BC139755; AAI39756.1; -; mRNA.
DR   CCDS; CCDS55242.1; -. [Q9H2Y9-2]
DR   CCDS; CCDS55243.1; -. [Q9H2Y9-3]
DR   CCDS; CCDS6205.1; -. [Q9H2Y9-1]
DR   RefSeq; NP_001139480.1; NM_001146008.1. [Q9H2Y9-3]
DR   RefSeq; NP_001139481.1; NM_001146009.1. [Q9H2Y9-2]
DR   RefSeq; NP_112220.2; NM_030958.2. [Q9H2Y9-1]
DR   RefSeq; XP_005251370.1; XM_005251313.2. [Q9H2Y9-2]
DR   RefSeq; XP_016869372.1; XM_017013883.1. [Q9H2Y9-3]
DR   BioGRID; 123587; 2.
DR   IntAct; Q9H2Y9; 2.
DR   STRING; 9606.ENSP00000260126; -.
DR   MEROPS; I01.972; -.
DR   TCDB; 2.A.60.1.16; the organo anion transporter (oat) family.
DR   GlyGen; Q9H2Y9; 7 sites.
DR   iPTMnet; Q9H2Y9; -.
DR   PhosphoSitePlus; Q9H2Y9; -.
DR   BioMuta; SLCO5A1; -.
DR   DMDM; 296452911; -.
DR   PaxDb; Q9H2Y9; -.
DR   PeptideAtlas; Q9H2Y9; -.
DR   PRIDE; Q9H2Y9; -.
DR   ProteomicsDB; 21498; -.
DR   ProteomicsDB; 32322; -.
DR   ProteomicsDB; 80635; -. [Q9H2Y9-1]
DR   Antibodypedia; 12199; 32 antibodies.
DR   DNASU; 81796; -.
DR   Ensembl; ENST00000260126; ENSP00000260126; ENSG00000137571. [Q9H2Y9-1]
DR   Ensembl; ENST00000524945; ENSP00000434422; ENSG00000137571. [Q9H2Y9-3]
DR   Ensembl; ENST00000530307; ENSP00000431611; ENSG00000137571. [Q9H2Y9-2]
DR   GeneID; 81796; -.
DR   KEGG; hsa:81796; -.
DR   UCSC; uc003xyk.4; human. [Q9H2Y9-1]
DR   CTD; 81796; -.
DR   DisGeNET; 81796; -.
DR   GeneCards; SLCO5A1; -.
DR   HGNC; HGNC:19046; SLCO5A1.
DR   HPA; ENSG00000137571; Tissue enhanced (heart muscle, lymphoid tissue, skeletal muscle, tongue).
DR   MIM; 613543; gene.
DR   neXtProt; NX_Q9H2Y9; -.
DR   OpenTargets; ENSG00000137571; -.
DR   PharmGKB; PA134948571; -.
DR   VEuPathDB; HostDB:ENSG00000137571.10; -.
DR   eggNOG; KOG3626; Eukaryota.
DR   GeneTree; ENSGT01030000234560; -.
DR   HOGENOM; CLU_008954_1_1_1; -.
DR   InParanoid; Q9H2Y9; -.
DR   OMA; PFSEAIN; -.
DR   PhylomeDB; Q9H2Y9; -.
DR   TreeFam; TF317540; -.
DR   PathwayCommons; Q9H2Y9; -.
DR   BioGRID-ORCS; 81796; 1 hit in 979 CRISPR screens.
DR   ChiTaRS; SLCO5A1; human.
DR   GenomeRNAi; 81796; -.
DR   Pharos; Q9H2Y9; Tdark.
DR   PRO; PR:Q9H2Y9; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q9H2Y9; protein.
DR   Bgee; ENSG00000137571; Expressed in quadriceps femoris and 126 other tissues.
DR   ExpressionAtlas; Q9H2Y9; baseline and differential.
DR   Genevisible; Q9H2Y9; HS.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR   GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004156; OATP.
DR   PANTHER; PTHR11388; PTHR11388; 1.
DR   Pfam; PF07648; Kazal_2; 1.
DR   Pfam; PF03137; OATP; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   SUPFAM; SSF103473; SSF103473; 2.
DR   TIGRFAMs; TIGR00805; oat; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..848
FT                   /note="Solute carrier organic anion transporter family
FT                   member 5A1"
FT                   /id="PRO_0000191070"
FT   TOPO_DOM        1..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..168
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..195
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..220
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..260
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..290
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..329
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        330..344
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..369
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        370..427
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..449
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        450..469
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        470..493
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        494..497
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        498..521
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        522..651
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        652..674
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        675..683
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        684..709
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        710..742
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        743..760
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        761..808
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          549..603
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          821..848
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        228
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        241
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        469
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        550
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        590
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        597
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        730
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        555..585
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        561..581
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        570..601
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   VAR_SEQ         420..474
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_045498"
FT   VAR_SEQ         675..687
FT                   /note="RSVEDEERPFALG -> SIHSYSNLLWSSH (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_045499"
FT   VAR_SEQ         688..848
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_045500"
FT   VARIANT         33
FT                   /note="L -> F (in dbSNP:rs3750266)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_022041"
FT   CONFLICT        40
FT                   /note="V -> A (in Ref. 2; BAG51109)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        264
FT                   /note="V -> L (in Ref. 1; AAG42207)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        457
FT                   /note="K -> E (in Ref. 2; BAG51109)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   848 AA;  91864 MW;  F213B18FE8389596 CRC64;
     MDEGTGLQPG AGEQLEAPAT AEAVQERCEP ETLRSKSLPV LSSASCRPSL SPTSGDANPA
     FGCVDSSGHQ ELKQGPNPLA PSPSAPSTSA GLGDCNHRVD LSKTFSVSSA LAMLQERRCL
     YVVLTDSRCF LVCMCFLTFI QALMVSGYLS SVITTIERRY SLKSSESGLL VSCFDIGNLV
     VVVFVSYFGG RGRRPLWLAV GGLLIAFGAA LFALPHFISP PYQIQELNAS APNDGLCQGG
     NSTATLEPPA CPKDSGGNNH WVYVALFICA QILIGMGSTP IYTLGPTYLD DNVKKENSSL
     YLAIMYVMGA LGPAVGYLLG GLLIGFYVDP RNPVHLDQND PRFIGNWWSG FLLCAIAMFL
     VIFPMFTFPK KLPPRHKKKK KKKFSVDAVS DDDVLKEKSN NSEQADKKVS SMGFGKDVRD
     LPRAAVRILS NMTFLFVSLS YTAESAIVTA FITFIPKFIE SQFGIPASNA SIYTGVIIVP
     SAGVGIVLGG YIIKKLKLGA RESAKLAMIC SGVSLLCFST LFIVGCESIN LGGINIPYTT
     GPSLTMPHRN LTGSCNVNCG CKIHEYEPVC GSDGITYFNP CLAGCVNSGN LSTGIRNYTE
     CTCVQSRQVI TPPTVGQRSQ LRVVIVKTYL NENGYAVSGK CKRTCNTLIP FLVFLFIVTF
     ITACAQPSAI IVTLRSVEDE ERPFALGMQF VLLRTLAYIP TPIYFGAVID TTCMLWQQEC
     GVQGSCWEYN VTSFRFVYFG LAAGLKFVGF IFIFLAWYSI KYKEDGLQRR RQREFPLSTV
     SERVGHPDNA RTRSCPAFST QGEFHEETGL QKGIQCAAQT YPGPFPEAIS SSADPGLEES
     PAALEPPS
//