ID   CCD68_HUMAN             Reviewed;         335 AA.
AC   Q9H2F9; B2R9I3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   02-OCT-2024, entry version 145.
DE   RecName: Full=Coiled-coil domain-containing protein 68;
DE   AltName: Full=Cutaneous T-cell lymphoma-associated antigen se57-1;
DE            Short=CTCL-associated antigen se57-1;
GN   Name=CCDC68;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=11149944; DOI=10.1073/pnas.98.2.629;
RA   Eichmueller S., Usener D., Dummer R., Stein A., Thiel D., Schadendorf D.;
RT   "Serological detection of cutaneous T-cell lymphoma-associated antigens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-249.
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=15142679; DOI=10.1016/j.canlet.2003.11.021;
RA   Gerhardt A., Usener D., Keese M., Sturm J., Schadendorf D., Eichmueller S.;
RT   "Tissue expression and sero-reactivity of tumor-specific antigens in
RT   colorectal cancer.";
RL   Cancer Lett. 208:197-206(2004).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH CEP170.
RX   PubMed=28422092; DOI=10.1038/ncomms15057;
RA   Huang N., Xia Y., Zhang D., Wang S., Bao Y., He R., Teng J., Chen J.;
RT   "Hierarchical assembly of centriole subdistal appendages via centrosome
RT   binding proteins CCDC120 and CCDC68.";
RL   Nat. Commun. 8:15057-15057(2017).
CC   -!- FUNCTION: Centriolar protein required for centriole subdistal appendage
CC       assembly and microtubule anchoring in interphase cells
CC       (PubMed:28422092). Together with CCDC120, cooperate with subdistal
CC       appendage components ODF2, NIN and CEP170 for hierarchical subdistal
CC       appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:28422092}.
CC   -!- SUBUNIT: Interacts with CEP170 (PubMed:28422092).
CC   -!- INTERACTION:
CC       Q9H2F9; Q5SW79: CEP170; NbExp=7; IntAct=EBI-2813327, EBI-1104799;
CC       Q9H2F9; P63172: DYNLT1; NbExp=3; IntAct=EBI-2813327, EBI-1176455;
CC       Q9H2F9; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-2813327, EBI-3044087;
CC       Q9H2F9; Q9UBB9: TFIP11; NbExp=8; IntAct=EBI-2813327, EBI-1105213;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000269|PubMed:28422092}.
CC       Note=Localizes to the subdistal appendages of centrioles
CC       (PubMed:28422092). {ECO:0000269|PubMed:28422092}.
CC   -!- TISSUE SPECIFICITY: Expressed in bone marrow, colon, small intestine,
CC       spleen, testis, trachea and cutaneous T-cell lymphoma (CTCL).
CC       {ECO:0000269|PubMed:11149944, ECO:0000269|PubMed:15142679}.
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DR   EMBL; AF273051; AAG34911.1; -; mRNA.
DR   EMBL; AK313793; BAG36530.1; -; mRNA.
DR   EMBL; BC029508; AAH29508.1; -; mRNA.
DR   CCDS; CCDS11959.1; -.
DR   RefSeq; NP_001137301.1; NM_001143829.1.
DR   RefSeq; NP_079490.1; NM_025214.2.
DR   RefSeq; XP_006722615.1; XM_006722552.3.
DR   RefSeq; XP_011524500.1; XM_011526198.2.
DR   RefSeq; XP_011524501.1; XM_011526199.2.
DR   RefSeq; XP_011524502.1; XM_011526200.2.
DR   RefSeq; XP_011524503.1; XM_011526201.2.
DR   AlphaFoldDB; Q9H2F9; -.
DR   SMR; Q9H2F9; -.
DR   BioGRID; 123235; 24.
DR   IntAct; Q9H2F9; 27.
DR   STRING; 9606.ENSP00000466690; -.
DR   iPTMnet; Q9H2F9; -.
DR   PhosphoSitePlus; Q9H2F9; -.
DR   BioMuta; CCDC68; -.
DR   DMDM; 74733556; -.
DR   MassIVE; Q9H2F9; -.
DR   PaxDb; 9606-ENSP00000466690; -.
DR   PeptideAtlas; Q9H2F9; -.
DR   ProteomicsDB; 80543; -.
DR   Antibodypedia; 53345; 122 antibodies from 21 providers.
DR   DNASU; 80323; -.
DR   Ensembl; ENST00000337363.8; ENSP00000337209.3; ENSG00000166510.14.
DR   Ensembl; ENST00000432185.5; ENSP00000413406.1; ENSG00000166510.14.
DR   Ensembl; ENST00000591504.6; ENSP00000466690.1; ENSG00000166510.14.
DR   GeneID; 80323; -.
DR   KEGG; hsa:80323; -.
DR   MANE-Select; ENST00000591504.6; ENSP00000466690.1; NM_025214.3; NP_079490.1.
DR   UCSC; uc002lfs.4; human.
DR   AGR; HGNC:24350; -.
DR   CTD; 80323; -.
DR   DisGeNET; 80323; -.
DR   GeneCards; CCDC68; -.
DR   HGNC; HGNC:24350; CCDC68.
DR   HPA; ENSG00000166510; Tissue enhanced (intestine, placenta).
DR   MIM; 616909; gene.
DR   neXtProt; NX_Q9H2F9; -.
DR   OpenTargets; ENSG00000166510; -.
DR   PharmGKB; PA143485420; -.
DR   VEuPathDB; HostDB:ENSG00000166510; -.
DR   eggNOG; ENOG502RXID; Eukaryota.
DR   GeneTree; ENSGT00950000183065; -.
DR   HOGENOM; CLU_071853_0_0_1; -.
DR   InParanoid; Q9H2F9; -.
DR   OMA; KDEIRHN; -.
DR   OrthoDB; 4169556at2759; -.
DR   PhylomeDB; Q9H2F9; -.
DR   PathwayCommons; Q9H2F9; -.
DR   SignaLink; Q9H2F9; -.
DR   BioGRID-ORCS; 80323; 7 hits in 1150 CRISPR screens.
DR   ChiTaRS; CCDC68; human.
DR   GenomeRNAi; 80323; -.
DR   Pharos; Q9H2F9; Tbio.
DR   PRO; PR:Q9H2F9; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; Q9H2F9; protein.
DR   Bgee; ENSG00000166510; Expressed in rectum and 133 other cell types or tissues.
DR   ExpressionAtlas; Q9H2F9; baseline and differential.
DR   GO; GO:0120103; C:centriolar subdistal appendage; IDA:GO_Central.
DR   GO; GO:0005814; C:centriole; IDA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   GO; GO:0034454; P:microtubule anchoring at centrosome; IMP:GO_Central.
DR   GO; GO:0008104; P:protein localization; IMP:GO_Central.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   InterPro; IPR051375; Tuftelin_GRINL1A/MYZAP/CCD68.
DR   PANTHER; PTHR23171:SF3; COILED-COIL DOMAIN-CONTAINING PROTEIN 68; 1.
DR   PANTHER; PTHR23171; GDOWN1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Proteomics identification;
KW   Reference proteome.
FT   CHAIN           1..335
FT                   /note="Coiled-coil domain-containing protein 68"
FT                   /id="PRO_0000264611"
FT   COILED          101..305
FT                   /evidence="ECO:0000255"
FT   VARIANT         249
FT                   /note="V -> A (in dbSNP:rs34751112)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_050762"
SQ   SEQUENCE   335 AA;  38869 MW;  2D7C0DFAC964A815 CRC64;
     MTTVTVTTEI PPRDKMEDNS ALYESTSAHI IEETEYVKKI RTTLQKIRTQ MFKDEIRHDS
     TNHKLDAKHC GNLQQGSDSE MDPSCCSLDL LMKKIKGKDL QLLEMNKENE VLKIKLQASR
     EAGAAALRNV AQRLFENYQT QSEEVRKKQE DSKQLLQVNK LEKEQKLKQH VENLNQVAEK
     LEEKHSQITE LENLVQRMEK EKRTLLERKL SLENKLLQLK SSATYGKSCQ DLQREISILQ
     EQISHLQFVI HSQHQNLRSV IQEMEGLKNN LKEQDKRIEN LREKVNILEA QNKELKTQVA
     LSSETPRTKV SKAVSTSELK TEGVSPYLML IRLRK
//