ID Q9H2E0_HUMAN Unreviewed; 83 AA. AC Q9H2E0; DT 01-MAR-2001, integrated into UniProtKB/TrEMBL. DT 01-MAR-2001, sequence version 1. DT 24-JUL-2024, entry version 96. DE SubName: Full=Neuropilin-1 {ECO:0000313|EMBL:AAG41893.1}; DE Flags: Fragment; GN Name=NRP1 {ECO:0000313|EMBL:AAG41893.1}; GN Synonyms=DKFZp686M1967 {ECO:0000313|EMBL:CAH10397.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAG41893.1}; RN [1] {ECO:0000313|EMBL:AAG41893.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11112349; DOI=10.1006/geno.2000.6381; RA Rossignol M., Gagnon M.L., Klagsbrun M.; RT "Genomic organization of human neuropilin-1 and neuropilin-2 genes: RT identification and distribution of splice variants and soluble isoforms."; RL Genomics 70:211-222(2000). RN [2] {ECO:0000313|EMBL:CAH10397.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Endometrium carcinoma cell line {ECO:0000313|EMBL:CAH10397.1}; RG The German cDNA Consortium; RA Bahr A., Lauber J., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., RA Han M., Wiemann S.; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AH010078; AAG41893.1; -; Genomic_DNA. DR EMBL; AL833608; CAH10397.1; -; mRNA. DR AlphaFoldDB; Q9H2E0; -. DR PeptideAtlas; Q9H2E0; -. DR ChiTaRS; NRP1; human. DR GO; GO:0030424; C:axon; IEA:TreeGrafter. DR GO; GO:0005925; C:focal adhesion; IEA:TreeGrafter. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0017154; F:semaphorin receptor activity; IEA:TreeGrafter. DR GO; GO:0038085; F:vascular endothelial growth factor binding; IEA:TreeGrafter. DR GO; GO:0005021; F:vascular endothelial growth factor receptor activity; IEA:TreeGrafter. DR GO; GO:0007411; P:axon guidance; IEA:TreeGrafter. DR GO; GO:0001755; P:neural crest cell migration; IEA:TreeGrafter. DR GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:TreeGrafter. DR GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:TreeGrafter. DR GO; GO:0030947; P:regulation of vascular endothelial growth factor receptor signaling pathway; IEA:TreeGrafter. DR GO; GO:0009611; P:response to wounding; IEA:TreeGrafter. DR GO; GO:0002040; P:sprouting angiogenesis; IEA:TreeGrafter. DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:TreeGrafter. DR GO; GO:0001570; P:vasculogenesis; IEA:TreeGrafter. DR CDD; cd00041; CUB; 1. DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1. DR InterPro; IPR000859; CUB_dom. DR InterPro; IPR050633; Neuropilin_MCO_CoagFactor. DR InterPro; IPR035914; Sperma_CUB_dom_sf. DR PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR46806:SF4; NEUROPILIN-1; 1. DR Pfam; PF00431; CUB; 1. DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1. DR PROSITE; PS01180; CUB; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE- KW ProRule:PRU00059}; Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}. FT SIGNAL 1..21 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 22..83 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5010847898" FT DOMAIN 27..83 FT /note="CUB" FT /evidence="ECO:0000259|PROSITE:PS01180" FT DISULFID 27..54 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059" FT NON_TER 83 FT /evidence="ECO:0000313|EMBL:AAG41893.1" SQ SEQUENCE 83 AA; 9376 MW; 398AA6A822A407BB CRC64; MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP SEKCEWLIQA PDPYQRIMIN FNPHFDLEDR DCK //