ID Q9H2E0_HUMAN PRELIMINARY; PRT; 83 AA. AC Q9H2E0; DT 01-MAR-2001 (TrEMBLrel. 16, Created) DT 01-MAR-2001 (TrEMBLrel. 16, Last sequence update) DT 01-FEB-2005 (TrEMBLrel. 29, Last annotation update) DE Neuropilin-1 (Hypothetical protein DKFZp686M1967) (Fragment). GN Name=NRP1; Synonyms=DKFZp686M1967; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=20564205; PubMed=11112349; DOI=10.1006/geno.2000.6381; RA Rossignol M., Gagnon M.L., Klagsbrun M.; RT "Genomic organization of human neuropilin-1 and neuropilin-2 genes: RT identification and distribution of splice variants and soluble RT isoforms."; RL Genomics 70:211-222(2000). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Endometrium carcinoma cell line; RG The German cDNA Consortium; RA Bahr A., Lauber J., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., RA Han M., Wiemann S.; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Responsible for initiating activation of pancreatic CC proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase CC A). It catalyzes the conversion of trypsinogen to trypsin which in CC turn activates other proenzymes including chymotrypsinogen, CC procarboxypeptidases, and proelastases (By similarity). CC -!- CATALYTIC ACTIVITY: Activation of trypsinogen by selective CC cleavage of 6-Lys-|-Ile-7 bond. CC -!- SUBCELLULAR LOCATION: Type II membrane protein (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF280548; AAG41893.1; -. DR EMBL; AL833608; CAH10397.1; -. DR InterPro; IPR000859; CUB. DR Pfam; PF00431; CUB; 1. DR PROSITE; PS01180; CUB; 1. KW Hypothetical protein. FT NON_TER 83 83 SQ SEQUENCE 83 AA; 9376 MW; 398AA6A822A407BB CRC64; MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP SEKCEWLIQA PDPYQRIMIN FNPHFDLEDR DCK //