ID   IL25_HUMAN              Reviewed;         177 AA.
AC   Q9H293; Q8IZV3; Q8WXB0;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   23-JAN-2007, entry version 45.
DE   Interleukin-25 precursor (IL-25) (Interleukin-17E) (IL-17E).
GN   Name=IL25; Synonyms=IL17E; ORFNames=UNQ3120/PRO10272;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=11058597; DOI=10.1074/jbc.M008289200;
RA   Lee J., Ho W.-H., Maruoka M., Corpuz R.T., Baldwin D.T., Foster J.S.,
RA   Goddard A.D., Yansura D.G., Vandlen R.L., Wood W.I., Gurney A.L.;
RT   "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog
RT   IL-17Rh1.";
RL   J. Biol. Chem. 276:1660-1664(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   MEDLINE=21629216; PubMed=11754819; DOI=10.1016/S1074-7613(01)00243-6;
RA   Fort M.M., Cheung J., Yen D., Li J., Zurawski S.M., Lo S., Menon S.,
RA   Clifford T., Hunte B., Lesley R., Muchamuel T., Hurst S.D.,
RA   Zurawski G., Leach M.W., Gorman D.M., Rennick D.M.;
RT   "IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in
RT   vivo.";
RL   Immunity 15:985-995(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   MEDLINE=22224358; PubMed=12239140; DOI=10.1182/blood-2002-01-0012;
RA   Kim M.R., Manoukian R., Yeh R., Silbiger S.M., Danilenko D.M.,
RA   Scully S., Sun J., DeRose M.L., Stolina M., Chang D., Van G.Y.,
RA   Clarkin K., Nguyen H.Q., Yu Y.B., Jing S., Senaldi G., Elliott G.,
RA   Medlock E.S.;
RT   "Transgenic overexpression of human IL-17E results in eosinophilia, B-
RT   lymphocyte hyperplasia, and altered antibody production.";
RL   Blood 100:2330-2340(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PROTEIN SEQUENCE OF 33-47.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Induces activation of NF-kappa-B and stimulates
CC       production of the proinflammatory chemokine IL-8. Proinflammatory
CC       cytokine favoring Th2-type immune responses.
CC   -!- SUBCELLULAR LOCATION: Secreted protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9H293-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9H293-2; Sequence=VSP_010159;
CC   -!- TISSUE SPECIFICITY: Expressed at low levels in several tissues,
CC       including brain, kidney, lung, prostate, testis, spinal cord,
CC       adrenal gland, and trachea.
CC   -!- SIMILARITY: Belongs to the IL-17 family.
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DR   EMBL; AF305200; AAG40848.1; -; mRNA.
DR   EMBL; AF458059; AAL57622.1; -; mRNA.
DR   EMBL; AF461739; AAN39038.1; -; mRNA.
DR   EMBL; AY359127; AAQ89484.1; -; mRNA.
DR   EMBL; BC069565; AAH69565.1; -; mRNA.
DR   UniGene; Hs.302036; -.
DR   HSSP; Q96PD4; 1JPY.
DR   Ensembl; ENSG00000166090; Homo sapiens.
DR   KEGG; hsa:64806; -.
DR   HGNC; HGNC:13765; IL25.
DR   MIM; 605658; gene.
DR   ArrayExpress; Q9H293; -.
DR   GermOnline; ENSG00000166090; Homo sapiens.
DR   RZPD-ProtExp; IOH35138; -.
DR   RZPD-ProtExp; IOH40292; -.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0030380; F:interleukin-17E receptor binding; TAS:UniProtKB.
DR   InterPro; IPR010345; IL17.
DR   Pfam; PF06083; IL17; 1.
KW   Alternative splicing; Cytokine; Direct protein sequencing;
KW   Glycoprotein; Signal.
FT   SIGNAL        1     32
FT   CHAIN        33    177       Interleukin-25.
FT                                /FTId=PRO_0000015431.
FT   CARBOHYD    136    136       N-linked (GlcNAc...) (Potential).
FT   DISULFID    110    168       By similarity.
FT   DISULFID    115    170       By similarity.
FT   VAR_SEQ       1     18       MRERPRLGEDSSLISLFL -> MY (in isoform 2).
FT                                /FTId=VSP_010159.
FT   CONFLICT    177    177       G -> A (in Ref. 2).
SQ   SEQUENCE   177 AA;  20330 MW;  52D895710CD59871 CRC64;
     MRERPRLGED SSLISLFLQV VAFLAMVMGT HTYSHWPSCC PSKGQDTSEE LLRWSTVPVP
     PLEPARPNRH PESCRASEDG PLNSRAISPW RYELDRDLNR LPQDLYHARC LCPHCVSLQT
     GSHMDPRGNS ELLYHNQTVF YRRPCHGEKG THKGYCLERR LYRVSLACVC VRPRVMG
//