ID   VPS16_HUMAN    STANDARD;      PRT;   839 AA.
AC   Q9H269; Q8WU31; Q96EE7; Q96N92; Q9H1Q4; Q9H1Q5;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   Vacuolar protein sorting 16 (hVPS16).
GN   Name=VPS16;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ISOFORM 1).
RX   MEDLINE=21147934; PubMed=11250079; DOI=10.1016/S0378-1119(01)00333-X;
RA   Huizing M., Didier A., Walenta J., Anikster Y., Gahl W.A., Kraemer H.;
RT   "Molecular cloning and characterization of human VPS18, VPS11, VPS16,
RT   and VPS33.";
RL   Gene 264:241-247(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ISOFORM 2).
RC   TISSUE=Kidney;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J.-I., Saito K., Kawai Y., Isono Y., Nakamura Y.,
RA   Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M.,
RA   Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H.,
RA   Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E.,
RA   Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M.,
RA   Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K.,
RA   Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y.,
RA   Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T.,
RA   Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O.,
RA   Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M.,
RA   Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE OF 146-839 (ISOFORM 1).
RC   TISSUE=Fetal brain;
RG   The German cDNA consortium;
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE OF 425-839 (ISOFORM 1).
RC   TISSUE=Duodenum, Lung, and Ovary;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [6]
RP   CHARACTERIZATION.
RX   MEDLINE=21369926; PubMed=11382755; DOI=10.1074/jbc.M101778200;
RA   Kim B.Y., Kraemer H., Yamamoto A., Kominami E., Kohsaka S.,
RA   Akazawa C.;
RT   "Molecular characterization of mammalian homologues of class c Vps
RT   proteins that interact with syntaxin-7.";
RL   J. Biol. Chem. 276:29393-29402(2001).
CC   -!- FUNCTION: May play a role in vesicle-mediated protein trafficking
CC       to lysosomal compartments and in membrane docking/fusion reactions
CC       of late endosomes/lysosomes.
CC   -!- SUBUNIT: Large hetero-oligomeric complex together with VPS11,
CC       VPS18 and VPS33A. Interacts with STX7.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic; peripheral membrane protein
CC       associated with late endosomes/lysosomes.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9H269-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9H269-2; Sequence=VSP_004018;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- CAUTION: Ref.3 (CAC21466) sequence differs from that shown due to
CC       erroneous gene model prediction.
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DR   EMBL; AF308801; AAG34678.1; -.
DR   EMBL; AK055787; BAB71013.1; -.
DR   EMBL; AL161656; CAC21465.1; -.
DR   EMBL; AL161656; CAC21466.1; ALT_SEQ.
DR   EMBL; AL834401; CAD39063.1; -.
DR   EMBL; BC012422; AAH12422.1; -.
DR   EMBL; BC021291; AAH21291.2; -.
DR   EMBL; BC064406; AAH64406.1; -.
DR   Ensembl; ENSG00000132670; Homo sapiens.
DR   Genew; HGNC:14584; VPS16.
DR   MIM; 608550; -.
DR   InterPro; IPR006925; Vps16_C.
DR   InterPro; IPR006926; Vps16_N.
DR   Pfam; PF04840; Vps16_C; 1.
DR   Pfam; PF04841; Vps16_N; 1.
KW   Alternative splicing; Membrane; Protein transport; Transport.
FT   VARSPLIC    300    443       Missing (in isoform 2).
FT                                /FTId=VSP_004018.
FT   CONFLICT     87     87       V -> A (in Ref. 2).
FT   CONFLICT    612    612       E -> G (in Ref. 2).
FT   CONFLICT    690    691       QF -> LQ (in Ref. 5; AAH12422).
FT   CONFLICT    768    768       N -> T (in Ref. 1).
FT   CONFLICT    809    809       E -> D (in Ref. 5; AAH12422).
SQ   SEQUENCE   839 AA;  94694 MW;  9C4292D455C19A60 CRC64;
     MDCYTANWNP LGDSAFYRKY ELYSMDWDLK EELRDCLVAA APYGGPIALL RNPWRKEKAA
     SVRPVLDIYS ASGMPLASLL WKSGPVVSLG WSAEEELLCV QEDGAVLVYG LHGDFRRHFS
     MGNEVLQNRV LDARIFHTEF GSGVAILTGA HRFTLSANVG DLKLRRMPEV PGLQSAPSCW
     TVLCQDRVAH ILLAVGPDLY LLDHAACSAV TPPGLAPGVS SFLQMAVSFT YRHLALFTDT
     GYIWMGTASL KEKLCEFNCN IRAPPKQMVW CSRPRSKERA VVVAWERRLM VVGDAPESIQ
     FVLDEDSYLV PELDGVRIFS RSTHEFLHEV PAASEEIFKI ASMAPGALLL EAQKEYEKES
     QKADEYLREI QELGQLTQAV QQCIEAAGHE HQPDMQKSLL RAASFGKCFL DRFPPDSFVH
     MCQDLRVLNA VRDYHIGIPL TYSQYKQLTI QVLLDRLVLR RLYPLAIQIC EYLRLPEVQG
     VSRILAHWAC YKVQQKDVSD EDVARAINQK LGDTPGVSYS DIAARAYGCG RTELAIKLLE
     YEPRSGEQVP LLLKMKRSKL ALSKAIESGD TDLVFTVLLH LKNELNRGDF FMTLRNQPMA
     LSLYRQFCKH QELETLKDLY NQDDNHQELG SFHIRASYAA EERIEGRVAA LQTAADAFYK
     AKNEFAAKAT EDQMRLLRLQ RRLEDELGGQ FLDLSLHDTV TTLILGGHNK RAEQLARDFR
     IPDKRLWWLK LTALADLEDW EELEKFSKSK KSPIGYLPFV EICMKQHNKY EAKKYASRVG
     PEQKVKALLL VGDVAQAADV AIEHRNEAEL SLVLSHCTGA TDGATADKIQ RARAQAQKK
//