ID   VP16_HUMAN     STANDARD;      PRT;   839 AA.
AC   Q9H269; Q8WU31; Q96EE7; Q96N92; Q9H1Q4; Q9H1Q5;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   Vacuolar protein sorting 16 (hVPS16).
GN   VPS16.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORM 1).
RX   MEDLINE=21147934; PubMed=11250079;
RA   Huizing M., Didier A., Walenta J., Anikster Y., Gahl W.A., Kraemer H.;
RT   "Molecular cloning and characterization of human VPS18, VPS11, VPS16,
RT   and VPS33.";
RL   Gene 264:241-247(2001).
RN   [2]
RP   SEQUENCE FROM N.A. (ISOFORM 2).
RC   TISSUE=Kidney;
RA   Tashiro H., Yamazaki M., Watanabe K., Kumagai A., Itakura S.,
RA   Fukuzumi Y., Fujimori Y., Komiyama M., Sugiyama T., Irie R.,
RA   Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J., Isono Y.,
RA   Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Yamashita H.,
RA   Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Kanda K., Wagatsuma M.,
RA   Murakawa K., Kanehori K., Takahashi-Fujii A., Oshima A., Sugiyama A.,
RA   Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K.,
RA   Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=21638749; PubMed=11780052;
RA   Deloukas P., Matthews L.H., Ashurst J., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [4]
RP   SEQUENCE OF 146-839 FROM N.A. (ISOFORM 1).
RC   TISSUE=Fetal brain;
RA   Bloecker H., Boecher M., Brandt P., Mewes H.-W., Weil B., Wiemann S.;
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   SEQUENCE OF 425-839 FROM N.A. (ISOFORM 1).
RC   TISSUE=Lung, and Ovary;
RX   MEDLINE=22388257; PubMed=12477932;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length
RT   human and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [6]
RP   CHARACTERIZATION.
RX   MEDLINE=21369926; PubMed=11382755;
RA   Kim B.Y., Kraemer H., Yamamoto A., Kominami E., Kohsaka S.,
RA   Akazawa C.;
RT   "Molecular characterization of mammalian homologues of class c Vps
RT   proteins that interact with syntaxin-7.";
RL   J. Biol. Chem. 276:29393-29402(2001).
CC   -!- FUNCTION: May play a role in vesicle-mediated protein trafficking
CC       to lysosomal compartments and in membrane docking/fusion reactions
CC       of late endosomes/lysosomes.
CC   -!- SUBUNIT: Large hetero-oligomeric complex together with VPS11,
CC       VPS18 and VPS33A. Interacts with STX7.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic; peripheral membrane protein
CC       associated with late endosomes/lysosomes.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9H269-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9H269-2; Sequence=VSP_004018;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- CAUTION: Ref.3 (CAC21466) sequence differs from that shown due to
CC       erroneous gene model prediction.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF308801; AAG34678.1; -.
DR   EMBL; AK055787; BAB71013.1; -.
DR   EMBL; AL161656; CAC21465.1; -.
DR   EMBL; AL161656; CAC21466.1; ALT_SEQ.
DR   EMBL; AL834401; CAD39063.1; -.
DR   EMBL; BC012422; AAH12422.1; -.
DR   EMBL; BC021291; AAH21291.1; -.
DR   Genew; HGNC:14584; VPS16.
DR   InterPro; IPR006925; Vps16_C.
DR   InterPro; IPR006926; Vps16_N.
DR   Pfam; PF04840; Vps16_C; 1.
DR   Pfam; PF04841; Vps16_N; 1.
KW   Transport; Protein transport; Membrane; Alternative splicing.
FT   VARSPLIC    300    443       Missing (in isoform 2).
FT                                /FTId=VSP_004018.
FT   CONFLICT     87     87       V -> A (IN REF. 2).
FT   CONFLICT    467    468       IQ -> RG (IN REF. 5; AAH21291).
FT   CONFLICT    612    612       E -> G (IN REF. 2).
FT   CONFLICT    690    691       QF -> LQ (IN REF. 5; AAH12422).
FT   CONFLICT    768    768       N -> T (IN REF. 1).
FT   CONFLICT    809    809       E -> D (IN REF. 5; AAH12422).
SQ   SEQUENCE   839 AA;  94693 MW;  9C4292D455C19A60 CRC64;
     MDCYTANWNP LGDSAFYRKY ELYSMDWDLK EELRDCLVAA APYGGPIALL RNPWRKEKAA
     SVRPVLDIYS ASGMPLASLL WKSGPVVSLG WSAEEELLCV QEDGAVLVYG LHGDFRRHFS
     MGNEVLQNRV LDARIFHTEF GSGVAILTGA HRFTLSANVG DLKLRRMPEV PGLQSAPSCW
     TVLCQDRVAH ILLAVGPDLY LLDHAACSAV TPPGLAPGVS SFLQMAVSFT YRHLALFTDT
     GYIWMGTASL KEKLCEFNCN IRAPPKQMVW CSRPRSKERA VVVAWERRLM VVGDAPESIQ
     FVLDEDSYLV PELDGVRIFS RSTHEFLHEV PAASEEIFKI ASMAPGALLL EAQKEYEKES
     QKADEYLREI QELGQLTQAV QQCIEAAGHE HQPDMQKSLL RAASFGKCFL DRFPPDSFVH
     MCQDLRVLNA VRDYHIGIPL TYSQYKQLTI QVLLDRLVLR RLYPLAIQIC EYLRLPEVQG
     VSRILAHWAC YKVQQKDVSD EDVARAINQK LGDTPGVSYS DIAARAYGCG RTELAIKLLE
     YEPRSGEQVP LLLKMKRSKL ALSKAIESGD TDLVFTVLLH LKNELNRGDF FMTLRNQPMA
     LSLYRQFCKH QELETLKDLY NQDDNHQELG SFHIRASYAA EERIEGRVAA LQTAADAFYK
     AKNEFAAKAT EDQMRLLRLQ RRLEDELGGQ FLDLSLHDTV TTLILGGHNK RAEQLARDFR
     IPDKRLWWLK LTALADLEDW EELEKFSKSK KSPIGYLPFV EICMKQHNKY EAKKYASRVG
     PEQKVKALLL VGDVAQAADV AIEHRNEAEL SLVLSHCTGA TDGATADKIQ RARAQAQKK
//