ID WF10A_HUMAN STANDARD; PRT; 79 AA. AC Q9H1F0; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 01-FEB-2005 (Rel. 46, Last annotation update) DE WAP four-disulfide core domain protein 10A precursor (Putative DE protease inhibitor WAP10A). GN Name=WFDC10A; Synonyms=C20orf146, WAP10; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22304654; PubMed=12206714; DOI=10.1042/BJ20020869; RA Clauss A., Lilja H., Lundwall A.; RT "A locus on human chromosome 20 contains several genes expressing RT protease inhibitor domains with homology to whey acidic protein."; RL Biochem. J. 368:233-242(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). CC -!- SUBCELLULAR LOCATION: Secreted (Potential). CC -!- SIMILARITY: Contains 1 WAP-type domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY038182; AAK72469.1; -. DR EMBL; AL031671; CAC18560.1; ALT_INIT. DR Ensembl; ENSG00000180305; Homo sapiens. DR Genew; HGNC:16139; WFDC10A. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR PROSITE; PS00317; 4_DISULFIDE_CORE; FALSE_NEG. KW Serine protease inhibitor; Signal. FT SIGNAL 1 21 Potential. FT CHAIN 22 79 WAP four-disulfide core domain protein FT 10A. FT DOMAIN 37 75 WAP. FT DISULFID 41 67 By similarity. FT DISULFID 50 71 By similarity. FT DISULFID 54 66 By similarity. FT DISULFID 60 75 By similarity. SQ SEQUENCE 79 AA; 8943 MW; 2C25A0B258ADFD7F CRC64; MAPQTLLPVL VLCVLLLQAQ GGYRDKKRMQ KTQLSPEIKV CQQQPKLYLC KHLCESHRDC QANNICCSTY CGNVCMSIL //