ID WF10A_HUMAN Reviewed; 79 AA. AC Q9H1F0; A2RRE9; Q5TGZ7; DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot. DT 19-OCT-2002, sequence version 2. DT 08-JUN-2016, entry version 102. DE RecName: Full=WAP four-disulfide core domain protein 10A; DE AltName: Full=Putative protease inhibitor WAP10A; DE Flags: Precursor; GN Name=WFDC10A; Synonyms=C20orf146, WAP10; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=12206714; DOI=10.1042/BJ20020869; RA Clauss A., Lilja H., Lundwall A.; RT "A locus on human chromosome 20 contains several genes expressing RT protease inhibitor domains with homology to whey acidic protein."; RL Biochem. J. 368:233-242(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. CC -!- SIMILARITY: Contains 1 WAP domain. {ECO:0000255|PROSITE- CC ProRule:PRU00722}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY038182; AAK72469.1; -; mRNA. DR EMBL; AL031671; CAI22433.1; -; Genomic_DNA. DR EMBL; CH471077; EAW75827.1; -; Genomic_DNA. DR EMBL; BC131579; AAI31580.1; -; mRNA. DR CCDS; CCDS13363.1; -. DR RefSeq; NP_542791.1; NM_080753.2. DR UniGene; Hs.199380; -. DR ProteinModelPortal; Q9H1F0; -. DR BioGrid; 126725; 2. DR STRING; 9606.ENSP00000361726; -. DR BioMuta; WFDC10A; -. DR DMDM; 24212617; -. DR EPD; Q9H1F0; -. DR PaxDb; Q9H1F0; -. DR PRIDE; Q9H1F0; -. DR TopDownProteomics; Q9H1F0; -. DR Ensembl; ENST00000372643; ENSP00000361726; ENSG00000180305. DR GeneID; 140832; -. DR KEGG; hsa:140832; -. DR UCSC; uc002xoz.4; human. DR CTD; 140832; -. DR GeneCards; WFDC10A; -. DR HGNC; HGNC:16139; WFDC10A. DR HPA; HPA055187; -. DR neXtProt; NX_Q9H1F0; -. DR PharmGKB; PA25688; -. DR eggNOG; ENOG410JI59; Eukaryota. DR eggNOG; ENOG41113ND; LUCA. DR GeneTree; ENSGT00730000111577; -. DR HOGENOM; HOG000236258; -. DR HOVERGEN; HBG058739; -. DR InParanoid; Q9H1F0; -. DR OMA; NICCSTF; -. DR OrthoDB; EOG72RN25; -. DR PhylomeDB; Q9H1F0; -. DR TreeFam; TF338513; -. DR GenomeRNAi; 140832; -. DR PRO; PR:Q9H1F0; -. DR Proteomes; UP000005640; Chromosome 20. DR Bgee; Q9H1F0; -. DR CleanEx; HS_WFDC10A; -. DR Genevisible; Q9H1F0; HS. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP_dom. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 1. PE 3: Inferred from homology; KW Complete proteome; Disulfide bond; Protease inhibitor; KW Reference proteome; Secreted; Serine protease inhibitor; Signal. FT SIGNAL 1 21 {ECO:0000255}. FT CHAIN 22 79 WAP four-disulfide core domain protein FT 10A. FT /FTId=PRO_0000041387. FT DOMAIN 34 79 WAP. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 41 67 {ECO:0000255|PROSITE-ProRule:PRU00722}. FT DISULFID 50 71 {ECO:0000255|PROSITE-ProRule:PRU00722}. FT DISULFID 54 66 {ECO:0000255|PROSITE-ProRule:PRU00722}. FT DISULFID 60 75 {ECO:0000255|PROSITE-ProRule:PRU00722}. SQ SEQUENCE 79 AA; 8943 MW; 2C25A0B258ADFD7F CRC64; MAPQTLLPVL VLCVLLLQAQ GGYRDKKRMQ KTQLSPEIKV CQQQPKLYLC KHLCESHRDC QANNICCSTY CGNVCMSIL //