ID   IL22_HUMAN     STANDARD;      PRT;   179 AA.
AC   Q9GZX6;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   25-OCT-2004 (Rel. 45, Last annotation update)
DE   Interleukin-22 precursor (IL-22) (IL-10-related T-cell-derived
DE   inducible factor) (IL-TIF) (UNQ3099/PRO10096).
GN   Name=IL22; Synonyms=ILTIF;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=20420346; PubMed=10954742; DOI=10.1073/pnas.170291697;
RA   Dumoutier L., Van Roost E., Colau D., Renauld J.-C.;
RT   "Human interleukin-10-related T cell-derived inducible factor:
RT   molecular cloning and functional characterization as an hepatocyte-
RT   stimulating factor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:10144-10149(2000).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=21069354; PubMed=11197690; DOI=10.1038/sj.gene.6363716;
RA   Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L.,
RA   Renauld J.-C.;
RT   "IL-TIF/IL-22: genomic organization and mapping of the human and mouse
RT   genes.";
RL   Genes Immun. 1:488-494(2000).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=20469498; PubMed=10875937; DOI=10.1074/jbc.M005304200;
RA   Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J.,
RA   Wood W.I., Goddard A.D., Gurney A.L.;
RT   "Interleukin (IL)-22, a novel human cytokine that signals through the
RT   interferon receptor-related proteins CRF2-4 and IL-22R.";
RL   J. Biol. Chem. 275:31335-31339(2000).
RN   [4]
RP   SEQUENCE FROM N.A., AND VARIANT GLY-158.
RA   Rieder M.J., Carrington D.P., Chung M.-W., Lee K.L., Poel C.L., Yi Q.,
RA   Nickerson D.A.;
RT   "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-
RT   FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu).";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.,
RA   Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A., Wood W.I.,
RA   Godowski P., Gray A.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [6]
RP   SEQUENCE OF 34-48.
RA   Zhang Z., Henzel W.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Submitted (JUN-2004) to Swiss-Prot.
CC   -!- FUNCTION: Cytokine that contributes to the inflammatory response
CC       in vivo.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-10 family.
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DR   EMBL; AJ277247; CAC06085.1; -.
DR   EMBL; AJ277248; CAC19409.1; -.
DR   EMBL; AF279437; AAG22064.1; -.
DR   EMBL; AF387519; AAK62468.1; -.
DR   EMBL; AY358890; AAQ89249.1; -.
DR   PDB; 1M4R; X-ray; A/B=29-179.
DR   Genew; HGNC:14900; IL22.
DR   MIM; 605330; -.
DR   GO; GO:0005576; C:extracellular; IC.
DR   GO; GO:0045518; F:interleukin-22 receptor binding; NAS.
DR   GO; GO:0006953; P:acute-phase response; NAS.
DR   GO; GO:0007267; P:cell-cell signaling; IC.
DR   GO; GO:0006954; P:inflammatory response; NAS.
DR   InterPro; IPR009079; 4_helix_cytokine.
DR   InterPro; IPR000098; Interleukin_10.
DR   ProDom; PD003687; Interleukin_10; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
KW   3D-structure; Cytokine; Direct protein sequencing; Glycoprotein;
KW   Polymorphism; Signal.
FT   SIGNAL        1     33
FT   CHAIN        34    179       Interleukin-22.
FT   CARBOHYD     54     54       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     68     68       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     97     97       N-linked (GlcNAc...) (Potential).
FT   VARIANT     158    158       S -> G.
FT                                /FTId=VAR_013078.
SQ   SEQUENCE   179 AA;  20011 MW;  3C35E64D60CF8767 CRC64;
     MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP YITNRTFMLA
     KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL EEVLFPQSDR FQPYMQEVVP
     FLARLSNRLS TCHIEGDDLH IQRNVQKLKD TVKKLGESGE IKAIGELDLL FMSLRNACI
//