ID   OR2B2_HUMAN             Reviewed;         357 AA.
AC   Q9GZK3; B2RNH2; Q9GZL2; Q9Y299;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 166.
DE   RecName: Full=Olfactory receptor 2B2;
DE   AltName: Full=Hs6M1-10;
DE   AltName: Full=Olfactory receptor 2B9;
DE   AltName: Full=Olfactory receptor 6-1;
DE            Short=OR6-1;
GN   Name=OR2B2; Synonyms=OR2B9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ARG-234.
RA   Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B.,
RA   Volz A., Younger R., Beck S.;
RT   "Polymorphic olfactory receptor genes and HLA loci constitute extended
RT   haplotypes.";
RL   (In) Kasahara M. (eds.);
RL   Major histocompatibility complex-evolution, structure, and function,
RL   pp.110-130, Springer-Verlag, Tokyo (2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2B2";
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DR   EMBL; AJ302584; CAC20504.1; -; Genomic_DNA.
DR   EMBL; AJ302585; CAC20505.1; -; Genomic_DNA.
DR   EMBL; AJ302586; CAC20506.1; -; Genomic_DNA.
DR   EMBL; AJ302587; CAC20507.1; -; Genomic_DNA.
DR   EMBL; AJ302588; CAC20508.1; -; Genomic_DNA.
DR   EMBL; AJ302589; CAC20509.1; -; Genomic_DNA.
DR   EMBL; AJ302590; CAC20510.1; -; Genomic_DNA.
DR   EMBL; AJ302591; CAC20511.1; -; Genomic_DNA.
DR   EMBL; AJ302592; CAC20512.1; -; Genomic_DNA.
DR   EMBL; AJ302593; CAC20513.1; -; Genomic_DNA.
DR   EMBL; Z98744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471081; EAX03125.1; -; Genomic_DNA.
DR   EMBL; BC136881; AAI36882.1; -; mRNA.
DR   EMBL; BC136901; AAI36902.1; -; mRNA.
DR   CCDS; CCDS4641.1; -.
DR   RefSeq; NP_149046.2; NM_033057.2.
DR   AlphaFoldDB; Q9GZK3; -.
DR   SMR; Q9GZK3; -.
DR   STRING; 9606.ENSP00000304419; -.
DR   GlyGen; Q9GZK3; 1 site.
DR   iPTMnet; Q9GZK3; -.
DR   PhosphoSitePlus; Q9GZK3; -.
DR   BioMuta; OR2B2; -.
DR   DMDM; 14423800; -.
DR   PaxDb; Q9GZK3; -.
DR   PeptideAtlas; Q9GZK3; -.
DR   PRIDE; Q9GZK3; -.
DR   ProteomicsDB; 80079; -.
DR   Antibodypedia; 25824; 62 antibodies from 18 providers.
DR   DNASU; 81697; -.
DR   Ensembl; ENST00000303324.4; ENSP00000304419.2; ENSG00000168131.4.
DR   GeneID; 81697; -.
DR   KEGG; hsa:81697; -.
DR   MANE-Select; ENST00000303324.4; ENSP00000304419.2; NM_033057.2; NP_149046.2.
DR   UCSC; uc011dkw.2; human.
DR   CTD; 81697; -.
DR   DisGeNET; 81697; -.
DR   GeneCards; OR2B2; -.
DR   HGNC; HGNC:13966; OR2B2.
DR   HPA; ENSG00000168131; Not detected.
DR   neXtProt; NX_Q9GZK3; -.
DR   PharmGKB; PA32141; -.
DR   VEuPathDB; HostDB:ENSG00000168131; -.
DR   eggNOG; ENOG502SI2C; Eukaryota.
DR   GeneTree; ENSGT01040000240395; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; Q9GZK3; -.
DR   OMA; PLCGHRE; -.
DR   OrthoDB; 933513at2759; -.
DR   PhylomeDB; Q9GZK3; -.
DR   TreeFam; TF336512; -.
DR   PathwayCommons; Q9GZK3; -.
DR   BioGRID-ORCS; 81697; 12 hits in 666 CRISPR screens.
DR   GeneWiki; OR2B2; -.
DR   GenomeRNAi; 81697; -.
DR   Pharos; Q9GZK3; Tdark.
DR   PRO; PR:Q9GZK3; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q9GZK3; protein.
DR   Bgee; ENSG00000168131; Expressed in skeletal muscle tissue and 11 other tissues.
DR   ExpressionAtlas; Q9GZK3; baseline and differential.
DR   Genevisible; Q9GZK3; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..357
FT                   /note="Olfactory receptor 2B2"
FT                   /id="PRO_0000150460"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..357
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         183
FT                   /note="A -> P (in dbSNP:rs9368537)"
FT                   /id="VAR_057536"
FT   VARIANT         234
FT                   /note="Q -> R (in allele 6M1-10*02; dbSNP:rs34957169)"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="VAR_010943"
FT   VARIANT         300
FT                   /note="A -> S (in dbSNP:rs34788973)"
FT                   /id="VAR_062014"
SQ   SEQUENCE   357 AA;  40412 MW;  53E2F82820EC440A CRC64;
     MNWVNKSVPQ EFILLVFSDQ PWLEIPPFVM FLFSYILTIF GNLTIILVSH VDFKLHTPMY
     FFLSNLSLLD LCYTTSTVPQ MLVNICNTRK VISYGGCVAQ LFIFLALGST ECLLLAVMCF
     DRFVAICRPL HYSIIMHQRL CFQLAAASWI SGFSNSVLQS TWTLKMPLCG HKEVDHFFCE
     VPALLKLSCV DTTANEAELF FISVLFLLIP VTLILISYAF IVQAVLRIQS AEGQRKAFGT
     CGSHLIVVSL FYGTAISMYL QPPSPSSKDR GKMVSLFCGI IAPMLNPLIY TLRNKEVKEA
     FKRLVAKSLL NQEIRNMQMI SFAKDTVLTY LTNFSASCPI FVITIENYCN LPQRKFP
//