ID Q9GKF0_BOVIN PRELIMINARY; PRT; 449 AA. AC Q9GKF0; DT 01-MAR-2001 (TrEMBLrel. 16, Created) DT 01-MAR-2001 (TrEMBLrel. 16, Last sequence update) DT 01-MAR-2004 (TrEMBLrel. 26, Last annotation update) DE Glycine receptor alpha 1 subunit isoform b. GN Name=Glra1; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=21109390; PubMed=11178872; DOI=10.1006/mcne.2000.0934; RA Pierce K.D., Handford C.A., Morris R., Vafa B., Dennis J.A., RA Healy P.J., Schofield P.R.; RT "A nonsense mutation in the alpha1 subunit of the inhibitory glycine RT receptor associated with bovine myoclonus."; RL Mol. Cell. Neurosci. 17:354-363(2001). CC -!- FUNCTION: The glycine receptor is a neurotransmitter-gated ion CC channel. Binding of glycine to its receptor increases the chloride CC conductance and thus produces hyperpolarization (inhibition of CC neuronal firing) (By similarity). CC -!- SUBUNIT: Pentamer composed of alpha (48 kDa) and beta (58 kDa) CC subunits. A third type of subunit (93 kDa) is a peripheral CC membrane protein associated with the cytoplasmic domains of the CC receptor core (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the ligand-gated ionic channel (TC 1.A.9) CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF268366; AAG41140.1; -. DR EMBL; AF268358; AAG41140.1; JOINED. DR EMBL; AF268359; AAG41140.1; JOINED. DR EMBL; AF268360; AAG41140.1; JOINED. DR EMBL; AF268361; AAG41140.1; JOINED. DR EMBL; AF268362; AAG41140.1; JOINED. DR EMBL; AF268363; AAG41140.1; JOINED. DR EMBL; AF268364; AAG41140.1; JOINED. DR EMBL; AF268365; AAG41140.1; JOINED. DR HSSP; P23415; 1MOT. DR GO; GO:0016021; C:integral to membrane; IEA. DR GO; GO:0045211; C:postsynaptic membrane; IEA. DR GO; GO:0005230; F:extracellular ligand-gated ion channel acti...; IEA. DR GO; GO:0004890; F:GABA-A receptor activity; IEA. DR GO; GO:0016934; F:glycine-gated chloride channel activity; IEA. DR GO; GO:0030594; F:neurotransmitter receptor activity; IEA. DR GO; GO:0006821; P:chloride transport; IEA. DR GO; GO:0006811; P:ion transport; IEA. DR InterPro; IPR006028; GABAA_recept. DR InterPro; IPR008127; Glycine_recepA. DR InterPro; IPR008128; Glycine_recepA1. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR006202; Neur_chan_LBD. DR InterPro; IPR006029; Neu_channel_memb. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00253; GABAARECEPTR. DR PRINTS; PR01673; GLYRALPHA. DR PRINTS; PR01674; GLYRALPHA1. DR PRINTS; PR00252; NRIONCHANNEL. DR TIGRFAMs; TIGR00860; LIC; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. KW Chloride channel; Ion transport; Ionic channel; Postsynaptic membrane; KW Receptor; Transmembrane; Transport. SQ SEQUENCE 449 AA; 51676 MW; DC75FB56F3114A4C CRC64; MYSFNTLRLY LWETIVFFSL AASKEAEAAR SASKPMSPSD FLDKLMGRTS GYDARIRPNF KGPPVNVSCN IFINSFGSIA ETTMDYRVNI FLRQQWNDPR XAYNEYPDDS LDLDPSMLDS IWKPDLFFAN EKGAHFHEIT TDNKLXRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE KDLRYCTKHY NTGKFTCIEA RFHLERQMGY YLIQMYIPSL LIVILSWISF WINMDAAPAR VGLGITTVLT MTTQSSGSRA SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRR HHKEDEAGEG RFNFSAYGMG PACLQAKDGI SVKGANNSNT TNPPPAPSKS PEEMRKLFIQ RAKKIDKISR IGFPMAFLIF NMFYWIIYKI VRREDVHNQ //