ID Q9FVZ0_ORYSJ Unreviewed; 546 AA. AC Q9FVZ0; DT 01-MAR-2001, integrated into UniProtKB/TrEMBL. DT 01-MAR-2001, sequence version 1. DT 18-APR-2012, entry version 49. DE RecName: Full=Folylpolyglutamate synthase; DE EC=6.3.2.17; DE AltName: Full=Folylpoly-gamma-glutamate synthetase; DE AltName: Full=Tetrahydrofolylpolyglutamate synthase; GN Name=OSJNBb0073N24.10; OS Oryza sativa subsp. japonica (Rice). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; OC Ehrhartoideae; Oryzeae; Oryza. OX NCBI_TaxID=39947; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare; RX PubMed=16100779; DOI=10.1038/nature03895; RG International rice genome sequencing project (IRGSP); RT "The map-based sequence of the rice genome."; RL Nature 436:793-800(2005). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Nipponbare; RX PubMed=18089549; DOI=10.1093/nar/gkm978; RG The rice annotation project (RAP); RT "The rice annotation project database (RAP-DB): 2008 update."; RL Nucleic Acids Res. 36:D1028-D1033(2008). CC -!- FUNCTION: Catalyzes conversion of folates to polyglutamate CC derivatives allowing concentration of folate compounds in the cell CC and the intracellular retention of these cofactors, which are CC important substrates for most of the folate-dependent enzymes that CC are involved in one-carbon transfer reactions involved in purine, CC pyrimidine and amino acid synthesis (By similarity). CC -!- CATALYTIC ACTIVITY: ATP + tetrahydropteroyl-(gamma-Glu)(n) + L- CC glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1). CC -!- COFACTOR: A monovalent cation (By similarity). CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolylpolyglutamate CC biosynthesis. CC -!- SIMILARITY: Belongs to the folylpolyglutamate synthase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC078840; AAG13624.1; -; Genomic_DNA. DR ProteinModelPortal; Q9FVZ0; -. DR STRING; Q9FVZ0; -. DR Gramene; Q9FVZ0; -. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004326; F:tetrahydrofolylpolyglutamate synthase activity; IEA:EC. DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR001645; Folylpolyglutamate_synth. DR InterPro; IPR018109; Folylpolyglutamate_synth_CS. DR InterPro; IPR023600; Folylpolyglutamate_synth_euk. DR InterPro; IPR004101; Mur_ligase_C. DR InterPro; IPR013221; Mur_ligase_cen. DR Gene3D; G3DSA:3.90.190.20; Mur_ligase_C; 1. DR Gene3D; G3DSA:3.40.1190.10; Mur_ligase_cen; 1. DR PANTHER; PTHR11136; Fpolygl_synthtse; 1. DR Pfam; PF08245; Mur_ligase_M; 1. DR PIRSF; PIRSF038895; FPGS; 1. DR SUPFAM; SSF53244; Mur_ligase_C; 1. DR SUPFAM; SSF53623; Mur_ligase_cen; 1. DR TIGRFAMs; TIGR01499; FolC; 1. DR PROSITE; PS01012; FOLYLPOLYGLU_SYNT_2; 1. PE 3: Inferred from homology; KW Complete proteome; Ligase; One-carbon metabolism. SQ SEQUENCE 546 AA; 60109 MW; 673296EE35FA5464 CRC64; MPPPRLAHLR RRSSSLLLLH HNHHHHRGGG SAPPHPLLRP PPPPQSHPFQ LLTPRAAMAS VAQPGVAAGS AEYEEVLGCI SSLITQKVRA DTGNRGNQWE LMAKYLQILE LEEPIARLKV VHVAGTKGKG STCTFAESIL RSCGFRTGLF TSPHLMDVRE RFRLNGLDIS EEKFIRYFWW CWNKLKDKTG GDIPMPAYFR FLALLAFKIF SDEQVDVAVL EVGLGGKYDA TNVVKAPVVC GISSLGYDHM EILGNTLGEI AGEKAGILKK GVPAYTVPQP EEAMSVLKHR ASELGVPLQV VQPLDPQQLD DQPLGLHGEH QYMNAGLAVA LVTLPDQFIE GLSSACLQGR AQIVPDPEVL SKDSSSLIFY LDGAHSPESM EICAKWFSCV TRKDEQQPGP LDQLHIGTNS RKILLFNCMS VRDPQRLLPC LLATCAQNGL QFDHALFVPN QSQYNKLGSH ASPPSERVQI DLSWQLSLQR VWEGLLHSNK GLNGSNSSTA SSVFESLPLA IKWLRETAQQ NQSTSYQVLV TGSLHLVGDV LRLLKE //