ID   CLP5_ARATH              Reviewed;         424 AA.
AC   Q9FLE2;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   13-SEP-2023, entry version 114.
DE   RecName: Full=Protein CLP1 homolog 5 {ECO:0000255|HAMAP-Rule:MF_03035};
DE   AltName: Full=CLP-like protein 5;
DE   AltName: Full=Protein CLP-SIMILAR PROTEIN 5;
GN   Name=CLPS5 {ECO:0000303|PubMed:18479511};
GN   OrderedLocusNames=At5g39930 {ECO:0000312|Araport:AT5G39930};
GN   ORFNames=MYH19.12 {ECO:0000312|EMBL:BAB10217.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA   Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT   features of the regions of 1,456,315 bp covered by nineteen physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:41-54(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y., Moskal W., Monaghan E., Wang W., Redman J.,
RA   Wu H.C., Utterback T., Town C.D.;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   INTERACTION WITH PCFS1; FIPS3 AND CPSF30, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18479511; DOI=10.1186/1471-2164-9-220;
RA   Hunt A.G., Xu R., Addepalli B., Rao S., Forbes K.P., Meeks L.R., Xing D.,
RA   Mo M., Zhao H., Bandyopadhyay A., Dampanaboina L., Marion A.,
RA   Von Lanken C., Li Q.Q.;
RT   "Arabidopsis mRNA polyadenylation machinery: comprehensive analysis of
RT   protein-protein interactions and gene expression profiling.";
RL   BMC Genomics 9:220-220(2008).
CC   -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC       dependent pre-mRNA 3'-end formation. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC   -!- SUBUNIT: Forms a complex with cleavage and polyadenylation specificity
CC       factor (CPSF) subunits PCFS1, FIPS3 and CPSF30.
CC       {ECO:0000269|PubMed:18479511}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9SR06,
CC       ECO:0000255|HAMAP-Rule:MF_03035}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03035}.
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DR   EMBL; AB010077; BAB10217.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED94492.1; -; Genomic_DNA.
DR   EMBL; AY954872; AAX55198.1; -; mRNA.
DR   RefSeq; NP_198809.2; NM_123356.3.
DR   AlphaFoldDB; Q9FLE2; -.
DR   SMR; Q9FLE2; -.
DR   BioGRID; 19241; 1.
DR   IntAct; Q9FLE2; 1.
DR   STRING; 3702.AT5G39930.1; -.
DR   PaxDb; Q9FLE2; -.
DR   ProteomicsDB; 246653; -.
DR   EnsemblPlants; AT5G39930.1; AT5G39930.1; AT5G39930.
DR   GeneID; 833990; -.
DR   Gramene; AT5G39930.1; AT5G39930.1; AT5G39930.
DR   KEGG; ath:AT5G39930; -.
DR   Araport; AT5G39930; -.
DR   TAIR; AT5G39930; CLPS5.
DR   eggNOG; KOG2749; Eukaryota.
DR   HOGENOM; CLU_018195_1_0_1; -.
DR   InParanoid; Q9FLE2; -.
DR   OMA; WITFPPL; -.
DR   OrthoDB; 56092at2759; -.
DR   PhylomeDB; Q9FLE2; -.
DR   PRO; PR:Q9FLE2; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FLE2; baseline and differential.
DR   Genevisible; Q9FLE2; AT.
DR   GO; GO:0005849; C:mRNA cleavage factor complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IBA:GO_Central.
DR   GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IBA:GO_Central.
DR   Gene3D; 2.60.120.1030; Clp1, DNA binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.330; Pre-mRNA cleavage complex subunit Clp1, C-terminal domain; 1.
DR   HAMAP; MF_03035; Clp1; 1.
DR   InterPro; IPR028606; Clp1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR010655; Clp1_C.
DR   InterPro; IPR038238; Clp1_C_sf.
DR   InterPro; IPR032324; Clp1_N.
DR   InterPro; IPR038239; Clp1_N_sf.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR   PANTHER; PTHR12755:SF19; PROTEIN CLP1 HOMOLOG 5; 1.
DR   Pfam; PF06807; Clp1; 1.
DR   Pfam; PF16573; CLP1_N; 1.
DR   Pfam; PF16575; CLP1_P; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; mRNA processing; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..424
FT                   /note="Protein CLP1 homolog 5"
FT                   /id="PRO_0000431352"
FT   BINDING         16
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT   BINDING         56
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT   BINDING         124..129
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
SQ   SEQUENCE   424 AA;  47489 MW;  50CC9AE9B42B32C9 CRC64;
     MFGPQIRRVK LEKQSELRIE LQPTSPLRLR LLDGKAEIFG YELPHEVWIT FPPLMTFAVF
     TWYGATIEID GITGNEYISC ETPMVNYLGL HNSLQVQRHR VTSSTRDSAS SQEGPRVIIV
     GDIDSGKSTL AKMLLNWAVK DGWKPTFVDL NVGQSSITIP GTIAAAPIKM LVDPVEGFPL
     DKALIHYFGL TNPSVNLRLY RTLVEELARE LKEEFSANAE SRASGMVIDT MGFIVREGYA
     LLLHAIRTFN ASLVIVVGQE EKLVYDLKKN LKFKKNLQVL NLEKSEGVFS RSSDFRKTLR
     NSNIQNYFYG VTNDLTVYTK TVKFSDVQVY RIGDFRVSGS TSAHQRGNDP LKITLVTIDE
     HLVNKVLAIS YAIKPDQIIS SIVAGFVCIK NVDISEERIT YVSPSAAELP SKILILGTLT
     WHVT
//