ID ZNF22_RAT STANDARD; PRT; 237 AA. AC Q9ERU2; Q5EAN1; DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot. DT 24-JAN-2006, sequence version 2. DT 07-FEB-2006, entry version 26. DE Zinc finger protein 22 (Kruppel-type zinc finger protein Krox-25). GN Name=Znf22; Synonyms=Krox25, Zfp422; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, RP AND DEVELOPMENTAL STAGE. RC STRAIN=Sprague-Dawley; RX PubMed=14706453; DOI=10.1016/j.ygeno.2003.08.006; RA Lee S.K., Kim Y.S., Lee S.S., Lee Y.J., Song I.S., Park S.C., RA Kozak C., Yamada Y.; RT "Molecular cloning, chromosomal mapping, and characteristic expression RT in tooth organ of rat and mouse Krox-25."; RL Genomics 83:243-253(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds DNA through the consensus sequence 5'-CAATG-3'. CC May be involved in transcriptional regulation and may play a role CC in tooth formation (By similarity). CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- TISSUE SPECIFICITY: Highly expressed in the ameloblast layer of CC mandibular incisors, moderately expressed in submandibular gland, CC calvaria, kidney and lung, and expressed at low levels in brain CC and thymus. CC -!- DEVELOPMENTAL STAGE: Highly expressed in presecretory ameloblasts CC with very high expression in secretory ameloblasts. Expression CC decreases in the maturation stage and is very low in the late CC maturation stage. CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. CC -!- SIMILARITY: Contains 5 C2H2-type zinc fingers. CC -!- CAUTION: Ref.1 sequence differs from that shown due to a CC frameshift in position 224. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF281635; AAG12467.1; ALT_FRAME; mRNA. DR EMBL; BC090354; AAH90354.1; -; mRNA. DR HSSP; P08046; 1F2I. DR Ensembl; ENSRNOG00000013379; Rattus norvegicus. DR RGD; 620229; Zfp422. DR GO; GO:0005634; C:nucleus; IDA. DR GO; GO:0003677; F:DNA binding; ISS. DR GO; GO:0042476; P:odontogenesis; NAS. DR GO; GO:0045449; P:regulation of transcription; NAS. DR InterPro; IPR007087; Znf_C2H2. DR InterPro; IPR007086; Znf_C2H2_sub. DR Pfam; PF00096; zf-C2H2; 5. DR PRINTS; PR00048; ZINCFINGER. DR ProDom; PD000003; Znf_C2H2; 5. DR SMART; SM00355; ZnF_C2H2; 5. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5. KW DNA-binding; Metal-binding; Nuclear protein; Repeat; Transcription; KW Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1 237 Zinc finger protein 22. FT /FTId=PRO_0000047350. FT ZN_FING 55 82 C2H2-type 1. FT ZN_FING 83 110 C2H2-type 2. FT ZN_FING 111 138 C2H2-type 3. FT ZN_FING 139 166 C2H2-type 4. FT ZN_FING 167 194 C2H2-type 5. FT CONFLICT 6 6 P -> PQ (in Ref. 1). FT CONFLICT 15 15 S -> T (in Ref. 1). FT CONFLICT 23 23 K -> R (in Ref. 1). FT CONFLICT 140 140 C -> Y (in Ref. 1). FT CONFLICT 179 179 S -> N (in Ref. 1). FT CONFLICT 190 190 K -> Q (in Ref. 1). SQ SEQUENCE 237 AA; 27286 MW; 9945E6C00AEC6624 CRC64; MRLGKPKGGI SRSASQGKTY ESKRKTARQR QKWGVAIRFD SGLSRRRRNV DEKPYKCTKC SKSFSQSSTL FQHKKIHTGK KSHKCADCGK SFFQSSNLIQ HRRIHTGEKP YKCDECGERF KQSSNLIQHQ RIHTGEKPYC CDECGRCFSQ SSHLIQHQRT HTGEKPYQCE ECDKCFSQSS HLRQHMKVHK EKKSHKRGKN ARAKTHPVSW KRGKGRKAVA GLRQVKGAAS GLFKKKK //