ID ZN22_RAT STANDARD; PRT; 225 AA. AC Q9ERU2; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Zinc finger protein 22 (Kruppel-type zinc finger protein Krox-25). GN Name=Znf22; Synonyms=Krox25; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND RP DEVELOPMENTAL STAGE. RC STRAIN=Sprague-Dawley; RX PubMed=14706453; DOI=10.1016/j.ygeno.2003.08.006; RA Lee S.K., Kim Y.S., Lee S.S., Lee Y.J., Song I.S., Park S.C., RA Kozak C., Yamada Y.; RT "Molecular cloning, chromosomal mapping, and characteristic expression RT in tooth organ of rat and mouse Krox-25."; RL Genomics 83:243-253(2004). CC -!- FUNCTION: Binds DNA through the consensus sequence 5'-CAATG-3'. CC May be involved in transcriptional regulation and may play a role CC in tooth formation (By similarity). CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- TISSUE SPECIFICITY: Highly expressed in the ameloblast layer of CC mandibular incisors, moderately expressed in submandibular gland, CC calvaria, kidney and lung, and expressed at low levels in brain CC and thymus. CC -!- DEVELOPMENTAL STAGE: Highly expressed in presecretory ameloblasts CC with very high expression in secretory ameloblasts. Expression CC decreases in the maturation stage and is very low in the late CC maturation stage. CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. CC -!- SIMILARITY: Contains 5 C2H2-type zinc fingers. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF281635; AAG12467.1; -. DR HSSP; P08046; 1F2I. DR Ensembl; ENSRNOG00000013379; Rattus norvegicus. DR RGD; 620229; Znf22. DR GO; GO:0005634; C:nucleus; IDA. DR GO; GO:0003677; F:DNA binding; ISS. DR GO; GO:0042476; P:odontogenesis; NAS. DR GO; GO:0045449; P:regulation of transcription; NAS. DR InterPro; IPR007087; Znf_C2H2. DR InterPro; IPR007086; Znf_C2H2_sub. DR Pfam; PF00096; zf-C2H2; 5. DR PRINTS; PR00048; ZINCFINGER. DR ProDom; PD000003; Znf_C2H2; 5. DR SMART; SM00355; ZnF_C2H2; 5. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5. KW DNA-binding; Metal-binding; Nuclear protein; Repeat; KW Transcription regulation; Zinc-finger. FT ZN_FING 56 83 C2H2-type 1. FT ZN_FING 84 111 C2H2-type 2. FT ZN_FING 112 139 C2H2-type 3. FT ZN_FING 140 167 C2H2-type 4. FT ZN_FING 168 195 C2H2-type 5. SQ SEQUENCE 225 AA; 26228 MW; 44F880957CACEB97 CRC64; MRLGKPQKGG ISRSATQGKT YESRRKTARQ RQKWGVAIRF DSGLSRRRRN VDEKPYKCTK CSKSFSQSST LFQHKKIHTG KKSHKCADCG KSFFQSSNLI QHRRIHTGEK PYKCDECGER FKQSSNLIQH QRIHTGEKPY YCDECGRCFS QSSHLIQHQR THTGEKPYQC EECDKCFSQN SHLRQHMKVH QEKKSHKRGK NARAKTHPVS WKRGKGRKAV AGLRR //