ID V1R41_MOUSE Reviewed; 310 AA. AC Q9EQ44; Q8VIC4; DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 19-FEB-2014, entry version 74. DE RecName: Full=Vomeronasal type-1 receptor 41; DE AltName: Full=Vomeronasal type-1 receptor A12; DE AltName: Full=Vomeronasal type-1 receptor B9; GN Name=Vmn1r41; Synonyms=V1ra12, V1rb9; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; RX PubMed=11116090; DOI=10.1101/gr.10.12.1958; RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.; RT "Sequence diversity and genomic organization of vomeronasal receptor RT genes in the mouse."; RL Genome Res. 10:1958-1967(2000). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Sam M., Matsunami H., Buck L.; RT "Vomeronasal receptor gene diversity in the mammalian genome."; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=12214233; DOI=10.1038/nature00955; RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., RA Wysocki C.J., Ogawa S., Zufall F., Mombaerts P.; RT "Deficient pheromone responses in mice lacking a cluster of RT vomeronasal receptor genes."; RL Nature 419:70-74(2002). CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation CC of social and reproductive behavior. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein CC (Potential). CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene CC (12% of the V1r repertoire) show a lack of chemosensory response CC to a subset of known pheromonal ligands and changes in maternal CC aggression as well as male reproductive behavior. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- SEQUENCE CAUTION: CC Sequence=BAB79218.1; Type=Erroneous initiation; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF291495; AAG42089.1; -; Genomic_DNA. DR EMBL; AB062901; BAB79218.1; ALT_INIT; Genomic_DNA. DR RefSeq; NP_444460.2; NM_053230.2. DR UniGene; Mm.377154; -. DR ProteinModelPortal; Q9EQ44; -. DR Ensembl; ENSMUST00000089417; ENSMUSP00000100705; ENSMUSG00000094586. DR Ensembl; ENSMUST00000178083; ENSMUSP00000137573; ENSMUSG00000094586. DR GeneID; 113857; -. DR KEGG; mmu:113857; -. DR UCSC; uc009cwl.3; mouse. DR CTD; 113857; -. DR MGI; MGI:2148520; Vmn1r41. DR eggNOG; NOG77521; -. DR GeneTree; ENSGT00530000062929; -. DR HOGENOM; HOG000231674; -. DR HOVERGEN; HBG101191; -. DR InParanoid; Q9EQ44; -. DR KO; K04614; -. DR OMA; LALTHIM; -. DR OrthoDB; EOG7K3TQZ; -. DR NextBio; 368007; -. DR PRO; PR:Q9EQ44; -. DR CleanEx; MM_V1RB9; -. DR Genevestigator; Q9EQ44; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro. DR GO; GO:0004872; F:receptor activity; ISS:MGI. DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW. DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR004072; Vmron_rcpt_1. DR Pfam; PF03402; V1R; 1. DR PRINTS; PR01534; VOMERONASL1R. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Complete proteome; Disulfide bond; KW G-protein coupled receptor; Glycoprotein; Membrane; KW Pheromone response; Receptor; Reference proteome; Transducer; KW Transmembrane; Transmembrane helix. FT CHAIN 1 310 Vomeronasal type-1 receptor 41. FT /FTId=PRO_0000239981. FT TOPO_DOM 1 20 Extracellular (Potential). FT TRANSMEM 21 41 Helical; Name=1; (Potential). FT TOPO_DOM 42 49 Cytoplasmic (Potential). FT TRANSMEM 50 70 Helical; Name=2; (Potential). FT TOPO_DOM 71 93 Extracellular (Potential). FT TRANSMEM 94 114 Helical; Name=3; (Potential). FT TOPO_DOM 115 134 Cytoplasmic (Potential). FT TRANSMEM 135 155 Helical; Name=4; (Potential). FT TOPO_DOM 156 190 Extracellular (Potential). FT TRANSMEM 191 211 Helical; Name=5; (Potential). FT TOPO_DOM 212 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 Helical; Name=6; (Potential). FT TOPO_DOM 260 269 Extracellular (Potential). FT TRANSMEM 270 290 Helical; Name=7; (Potential). FT TOPO_DOM 291 310 Cytoplasmic (Potential). FT CARBOHYD 159 159 N-linked (GlcNAc...) (Potential). FT DISULFID 85 172 By similarity. SQ SEQUENCE 310 AA; 35228 MW; 19D8ED1740455DAE CRC64; MNKANLLYTD TNMKTFLFSE VSVGISANSM LFIVHICILL GENRPKPINL YIAFLSLTQL MLLITMGLIV ADMFMSQGIW DSITCQSLIY LHRLLRGLTL CATCLLNVLW TITLSPRSSC LTKFKHKSPH HISGAFLFFC ALYMSFSSHL FLSIIATPNL TSEDFMYVTQ SCSLLSMSYS RTSMFSTAIA IREAFLISLF ALCSGYMVAL LWRHKKQAWD LHSTNVSSKS SPEQRATRTI MLLMSFFVVL YVLENAVFHS RMKFKDGSML YCVQIIVSHS YATVSPFVLI CTEKRMIKFW GSMFGRIVNI //