ID VN1B9_MOUSE Reviewed; 310 AA. AC Q9EQ44; Q8VIC4; DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 16-JUN-2009, entry version 39. DE RecName: Full=Vomeronasal type-1 receptor B9; DE AltName: Full=Vomeronasal type-1 receptor A12; GN Name=V1rb9; Synonyms=V1ra12; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; RX MEDLINE=20568485; PubMed=11116090; DOI=10.1101/gr.10.12.1958; RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.; RT "Sequence diversity and genomic organization of vomeronasal receptor RT genes in the mouse."; RL Genome Res. 10:1958-1967(2000). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Sam M., Matsunami H., Buck L.; RT "Vomeronasal receptor gene diversity in the mammalian genome."; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=12214233; DOI=10.1038/nature00955; RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., RA Wysocki C.J., Ogawa S., Zufall F., Mombaerts P.; RT "Deficient pheromone responses in mice lacking a cluster of RT vomeronasal receptor genes."; RL Nature 419:70-74(2002). CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation CC of social and reproductive behavior. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein CC (Potential). CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene CC (12% of the V1r repertoire) show a lack of chemosensory response CC to a subset of known pheromonal ligands and changes in maternal CC aggression as well as male reproductive behavior. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF291495; AAG42089.1; -; Genomic_DNA. DR EMBL; AB062901; BAB79218.1; ALT_INIT; Genomic_DNA. DR IPI; IPI00406440; -. DR RefSeq; NP_444460.1; -. DR UniGene; Mm.377154; -. DR Ensembl; ENSMUSG00000068234; Mus musculus. DR GeneID; 113857; -. DR KEGG; mmu:113857; -. DR MGI; MGI:2148520; V1rb9. DR HOVERGEN; Q9EQ44; -. DR OMA; Q9EQ44; CTRIINI. DR NextBio; 368007; -. DR CleanEx; MM_V1RB9; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IEA:UniProtKB-KW. DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW. DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI. DR InterPro; IPR000276; 7TM_GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_supfam. DR InterPro; IPR004072; Vmron_rcpt_1. DR PANTHER; PTHR11391; Vmron_rcpt_1; 1. DR Pfam; PF03402; V1R; 1. DR PRINTS; PR01534; VOMERONASL1R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; KW Glycoprotein; Membrane; Pheromone response; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 310 Vomeronasal type-1 receptor B9. FT /FTId=PRO_0000239981. FT TOPO_DOM 1 20 Extracellular (Potential). FT TRANSMEM 21 41 1 (Potential). FT TOPO_DOM 42 49 Cytoplasmic (Potential). FT TRANSMEM 50 70 2 (Potential). FT TOPO_DOM 71 93 Extracellular (Potential). FT TRANSMEM 94 114 3 (Potential). FT TOPO_DOM 115 134 Cytoplasmic (Potential). FT TRANSMEM 135 155 4 (Potential). FT TOPO_DOM 156 190 Extracellular (Potential). FT TRANSMEM 191 211 5 (Potential). FT TOPO_DOM 212 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT TOPO_DOM 260 269 Extracellular (Potential). FT TRANSMEM 270 290 7 (Potential). FT TOPO_DOM 291 310 Cytoplasmic (Potential). FT CARBOHYD 159 159 N-linked (GlcNAc...) (Potential). FT DISULFID 85 172 By similarity. SQ SEQUENCE 310 AA; 35228 MW; 19D8ED1740455DAE CRC64; MNKANLLYTD TNMKTFLFSE VSVGISANSM LFIVHICILL GENRPKPINL YIAFLSLTQL MLLITMGLIV ADMFMSQGIW DSITCQSLIY LHRLLRGLTL CATCLLNVLW TITLSPRSSC LTKFKHKSPH HISGAFLFFC ALYMSFSSHL FLSIIATPNL TSEDFMYVTQ SCSLLSMSYS RTSMFSTAIA IREAFLISLF ALCSGYMVAL LWRHKKQAWD LHSTNVSSKS SPEQRATRTI MLLMSFFVVL YVLENAVFHS RMKFKDGSML YCVQIIVSHS YATVSPFVLI CTEKRMIKFW GSMFGRIVNI //