ID V1R41_MOUSE Reviewed; 310 AA. AC Q9EQ44; Q8VIC4; DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 22-FEB-2023, entry version 114. DE RecName: Full=Vomeronasal type-1 receptor 41; DE AltName: Full=Vomeronasal type-1 receptor A12; DE AltName: Full=Vomeronasal type-1 receptor B9; GN Name=Vmn1r41; Synonyms=V1ra12 {ECO:0000312|EMBL:BAB79218.1}, V1rb9; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000312|EMBL:AAG42089.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42089.1}; RX PubMed=11116090; DOI=10.1101/gr.10.12.1958; RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.; RT "Sequence diversity and genomic organization of vomeronasal receptor genes RT in the mouse."; RL Genome Res. 10:1958-1967(2000). RN [2] {ECO:0000312|EMBL:BAB79218.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Sam M., Matsunami H., Buck L.; RT "Vomeronasal receptor gene diversity in the mammalian genome."; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000305} RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=12214233; DOI=10.1038/nature00955; RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J., RA Ogawa S., Zufall F., Mombaerts P.; RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal RT receptor genes."; RL Nature 419:70-74(2002). CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000255}. CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12% CC of the V1r repertoire) show a lack of chemosensory response to a subset CC of known pheromonal ligands and changes in maternal aggression as well CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- SEQUENCE CAUTION: CC Sequence=BAB79218.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF291495; AAG42089.1; -; Genomic_DNA. DR EMBL; AB062901; BAB79218.1; ALT_INIT; Genomic_DNA. DR RefSeq; NP_444460.2; NM_053230.2. DR RefSeq; XP_017176825.1; XM_017321336.1. DR AlphaFoldDB; Q9EQ44; -. DR SMR; Q9EQ44; -. DR BioGRID; 227525; 1. DR STRING; 10090.ENSMUSP00000100705; -. DR GlyCosmos; Q9EQ44; 1 site, No reported glycans. DR GlyGen; Q9EQ44; 1 site. DR PaxDb; Q9EQ44; -. DR DNASU; 113857; -. DR GeneID; 113857; -. DR KEGG; mmu:113857; -. DR UCSC; uc009cwl.3; mouse. DR AGR; MGI:2148520; -. DR CTD; 113857; -. DR MGI; MGI:2148520; Vmn1r41. DR eggNOG; ENOG502SNRJ; Eukaryota. DR InParanoid; Q9EQ44; -. DR OMA; TRTIMIL; -. DR OrthoDB; 4113734at2759; -. DR PhylomeDB; Q9EQ44; -. DR BioGRID-ORCS; 113857; 2 hits in 71 CRISPR screens. DR PRO; PR:Q9EQ44; -. DR Proteomes; UP000000589; Unplaced. DR RNAct; Q9EQ44; protein. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro. DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW. DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI. DR CDD; cd13949; 7tm_V1R_pheromone; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR004072; Vmron_rcpt_1. DR PANTHER; PTHR24062; VOMERONASAL TYPE-1 RECEPTOR; 1. DR PANTHER; PTHR24062:SF185; VOMERONASAL TYPE-1 RECEPTOR-RELATED; 1. DR Pfam; PF03402; V1R; 1. DR PRINTS; PR01534; VOMERONASL1R. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer; KW Transmembrane; Transmembrane helix. FT CHAIN 1..310 FT /note="Vomeronasal type-1 receptor 41" FT /id="PRO_0000239981" FT TOPO_DOM 1..20 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 21..41 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 42..49 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 50..70 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 71..93 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 94..114 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 115..134 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 135..155 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 156..190 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 191..211 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 212..238 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 239..259 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 260..269 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 270..290 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 291..310 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 159 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 85..172 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" SQ SEQUENCE 310 AA; 35228 MW; 19D8ED1740455DAE CRC64; MNKANLLYTD TNMKTFLFSE VSVGISANSM LFIVHICILL GENRPKPINL YIAFLSLTQL MLLITMGLIV ADMFMSQGIW DSITCQSLIY LHRLLRGLTL CATCLLNVLW TITLSPRSSC LTKFKHKSPH HISGAFLFFC ALYMSFSSHL FLSIIATPNL TSEDFMYVTQ SCSLLSMSYS RTSMFSTAIA IREAFLISLF ALCSGYMVAL LWRHKKQAWD LHSTNVSSKS SPEQRATRTI MLLMSFFVVL YVLENAVFHS RMKFKDGSML YCVQIIVSHS YATVSPFVLI CTEKRMIKFW GSMFGRIVNI //