ID VN1A7_MOUSE Reviewed; 309 AA. AC Q9EP79; DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 16-JUN-2009, entry version 38. DE RecName: Full=Vomeronasal type-1 receptor A7; DE AltName: Full=Vomeronasal receptor 3; DE AltName: Full=Pheromone receptor VN3; GN Name=V1ra7; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; RX MEDLINE=20568485; PubMed=11116090; DOI=10.1101/gr.10.12.1958; RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.; RT "Sequence diversity and genomic organization of vomeronasal receptor RT genes in the mouse."; RL Genome Res. 10:1958-1967(2000). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=21642638; PubMed=11752409; DOI=10.1073/pnas.012608399; RA Lane R.P., Cutforth T., Axel R., Hood L., Trask B.J.; RT "Sequence analysis of mouse vomeronasal receptor gene clusters reveals RT common promoter motifs and a history of recent expansion."; RL Proc. Natl. Acad. Sci. U.S.A. 99:291-296(2002). RN [3] RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=12214233; DOI=10.1038/nature00955; RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., RA Wysocki C.J., Ogawa S., Zufall F., Mombaerts P.; RT "Deficient pheromone responses in mice lacking a cluster of RT vomeronasal receptor genes."; RL Nature 419:70-74(2002). CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation CC of social and reproductive behavior. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein CC (Potential). CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene CC (12% of the V1r repertoire) show a lack of chemosensory response CC to a subset of known pheromonal ligands and changes in maternal CC aggression as well as male reproductive behavior. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF291486; AAG42080.1; -; Genomic_DNA. DR EMBL; AF129005; AAG43250.1; -; Genomic_DNA. DR IPI; IPI00109260; -. DR RefSeq; NP_444452.1; -. DR UniGene; Mm.435482; -. DR Ensembl; ENSMUSG00000060816; Mus musculus. DR GeneID; 113849; -. DR KEGG; mmu:113849; -. DR MGI; MGI:2148512; V1ra7. DR HOVERGEN; Q9EP79; -. DR OMA; Q9EP79; HILIAAI. DR NextBio; 367975; -. DR CleanEx; MM_V1RA7; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IEA:UniProtKB-KW. DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW. DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI. DR InterPro; IPR000276; 7TM_GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_supfam. DR InterPro; IPR004072; Vmron_rcpt_1. DR PANTHER; PTHR11391; Vmron_rcpt_1; 1. DR Pfam; PF03402; V1R; 1. DR PRINTS; PR01534; VOMERONASL1R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; KW Glycoprotein; Membrane; Pheromone response; Receptor; Transducer; KW Transmembrane. FT CHAIN 1 309 Vomeronasal type-1 receptor A7. FT /FTId=PRO_0000239962. FT TOPO_DOM 1 19 Extracellular (Potential). FT TRANSMEM 20 40 1 (Potential). FT TOPO_DOM 41 49 Cytoplasmic (Potential). FT TRANSMEM 50 70 2 (Potential). FT TOPO_DOM 71 93 Extracellular (Potential). FT TRANSMEM 94 114 3 (Potential). FT TOPO_DOM 115 134 Cytoplasmic (Potential). FT TRANSMEM 135 155 4 (Potential). FT TOPO_DOM 156 187 Extracellular (Potential). FT TRANSMEM 188 208 5 (Potential). FT TOPO_DOM 209 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 6 (Potential). FT TOPO_DOM 260 268 Extracellular (Potential). FT TRANSMEM 269 289 7 (Potential). FT TOPO_DOM 290 309 Cytoplasmic (Potential). FT CARBOHYD 159 159 N-linked (GlcNAc...) (Potential). FT DISULFID 85 172 By similarity. SQ SEQUENCE 309 AA; 35050 MW; 918D81704C2EF267 CRC64; MNKDHTLYCS VYIRNAFFSE IGIGISANSC LLLFHTFMFI RGHRPRLTDL PIGFVALIHL VMLLLAAYIT EDFFMSSGGW DDITCKLVIF LHRFFRSLSV CATCLLSVFQ AIILCPQSSH LAKLKQNSPH QLSYFFIFLS IFYTSISSHI LIAAIPTQNI TFVNLIYITN SCSFLPLSSS MQHTFSTLLA FRNVFVIGLM GLSTCYMATL LCRHKTRSQR LQNSKLSPKA TPEQRALRTI LMLMSFFLLM STFDSIISYS RTILQGNPLP FCFQILVAHS YAAVSPLLVL SNEKRITNLL ISMYEKIVL //