ID V1R52_MOUSE Reviewed; 309 AA. AC Q9EP79; DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 24-JAN-2024, entry version 123. DE RecName: Full=Vomeronasal type-1 receptor 52; DE AltName: Full=Pheromone receptor VN3; DE AltName: Full=Vomeronasal receptor 3; DE AltName: Full=Vomeronasal type-1 receptor A7; GN Name=Vmn1r52; Synonyms=V1ra7; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000312|EMBL:AAG42080.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42080.1}; RX PubMed=11116090; DOI=10.1101/gr.10.12.1958; RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.; RT "Sequence diversity and genomic organization of vomeronasal receptor genes RT in the mouse."; RL Genome Res. 10:1958-1967(2000). RN [2] {ECO:0000312|EMBL:AAG43250.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=11752409; DOI=10.1073/pnas.012608399; RA Lane R.P., Cutforth T., Axel R., Hood L., Trask B.J.; RT "Sequence analysis of mouse vomeronasal receptor gene clusters reveals RT common promoter motifs and a history of recent expansion."; RL Proc. Natl. Acad. Sci. U.S.A. 99:291-296(2002). RN [3] {ECO:0000305} RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=12214233; DOI=10.1038/nature00955; RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J., RA Ogawa S., Zufall F., Mombaerts P.; RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal RT receptor genes."; RL Nature 419:70-74(2002). CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000255}. CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12% CC of the V1r repertoire) show a lack of chemosensory response to a subset CC of known pheromonal ligands and changes in maternal aggression as well CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF291486; AAG42080.1; -; Genomic_DNA. DR EMBL; AF129005; AAG43250.1; -; Genomic_DNA. DR CCDS; CCDS20353.1; -. DR RefSeq; NP_444452.1; NM_053222.1. DR AlphaFoldDB; Q9EP79; -. DR SMR; Q9EP79; -. DR GlyCosmos; Q9EP79; 1 site, No reported glycans. DR GlyGen; Q9EP79; 1 site. DR PaxDb; 10090-ENSMUSP00000078760; -. DR DNASU; 113849; -. DR Ensembl; ENSMUST00000079832.3; ENSMUSP00000078760.3; ENSMUSG00000060816.4. DR Ensembl; ENSMUST00000226520.2; ENSMUSP00000154082.2; ENSMUSG00000060816.4. DR Ensembl; ENSMUST00000227893.2; ENSMUSP00000154024.2; ENSMUSG00000060816.4. DR Ensembl; ENSMUST00000228394.2; ENSMUSP00000153951.2; ENSMUSG00000060816.4. DR Ensembl; ENSMUST00000228665.2; ENSMUSP00000154275.2; ENSMUSG00000060816.4. DR GeneID; 113849; -. DR KEGG; mmu:113849; -. DR UCSC; uc009cww.1; mouse. DR AGR; MGI:2148512; -. DR CTD; 113849; -. DR MGI; MGI:2148512; Vmn1r52. DR VEuPathDB; HostDB:ENSMUSG00000060816; -. DR eggNOG; ENOG502SNRJ; Eukaryota. DR GeneTree; ENSGT01030000234553; -. DR HOGENOM; CLU_058641_0_0_1; -. DR InParanoid; Q9EP79; -. DR OMA; ISMYERI; -. DR OrthoDB; 4113734at2759; -. DR PhylomeDB; Q9EP79; -. DR BioGRID-ORCS; 113849; 3 hits in 37 CRISPR screens. DR PRO; PR:Q9EP79; -. DR Proteomes; UP000000589; Chromosome 6. DR RNAct; Q9EP79; Protein. DR Bgee; ENSMUSG00000060816; Expressed in lung. DR ExpressionAtlas; Q9EP79; differential. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro. DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW. DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI. DR CDD; cd13949; 7tm_V1R_pheromone; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR004072; Vmron_rcpt_1. DR PANTHER; PTHR24062; VOMERONASAL TYPE-1 RECEPTOR; 1. DR PANTHER; PTHR24062:SF5; VOMERONASAL TYPE-1 RECEPTOR 52-RELATED; 1. DR Pfam; PF03402; V1R; 1. DR PRINTS; PR01534; VOMERONASL1R. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer; KW Transmembrane; Transmembrane helix. FT CHAIN 1..309 FT /note="Vomeronasal type-1 receptor 52" FT /id="PRO_0000239962" FT TOPO_DOM 1..19 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 20..40 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 41..49 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 50..70 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 71..93 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 94..114 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 115..134 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 135..155 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 156..187 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 188..208 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 209..238 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 239..259 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 260..268 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 269..289 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 290..309 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 159 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 85..172 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" SQ SEQUENCE 309 AA; 35050 MW; 918D81704C2EF267 CRC64; MNKDHTLYCS VYIRNAFFSE IGIGISANSC LLLFHTFMFI RGHRPRLTDL PIGFVALIHL VMLLLAAYIT EDFFMSSGGW DDITCKLVIF LHRFFRSLSV CATCLLSVFQ AIILCPQSSH LAKLKQNSPH QLSYFFIFLS IFYTSISSHI LIAAIPTQNI TFVNLIYITN SCSFLPLSSS MQHTFSTLLA FRNVFVIGLM GLSTCYMATL LCRHKTRSQR LQNSKLSPKA TPEQRALRTI LMLMSFFLLM STFDSIISYS RTILQGNPLP FCFQILVAHS YAAVSPLLVL SNEKRITNLL ISMYEKIVL //