ID Q9DTF0_9HEPC Unreviewed; 3010 AA. AC Q9DTF0; DT 01-MAR-2001, integrated into UniProtKB/TrEMBL. DT 01-MAR-2001, sequence version 1. DT 28-JUL-2009, entry version 58. DE RecName: Full=Genome polyprotein; OS Hepatitis C virus. OC Viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; OC Hepacivirus. OX NCBI_TaxID=11103; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=HCVT050; RX PubMed=11348851; DOI=10.1016/S1386-6346(00)00141-8; RA Takahashi K., Iwata K., Matsumoto M., Matsumoto H., Nakao K., RA Hatahara T., Ohta Y., Kanai K., Maruo H., Baba K., Hijikata M., RA Mishiro S.; RT "Hepatitis C virus (HCV) genotype 1b sequences from fifteen patients RT with hepatocellular carcinoma: the 'progression score' revisited."; RL Hepatol. Res. 20:161-171(2001). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=92044457; PubMed=1658209; RA Oshima M., Tsuchiya M., Yagasaki M., Orita T., Hasegawa M., RA Tomonoh K., Kojima T., Hirata Y., Yamamoto O., Sho Y.; RT "cDNA clones of Japanese hepatitis C virus genomes derived from a RT single patient show sequence heterogeneity."; RL J. Gen. Virol. 72:2805-2809(1991). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB049087; BAB18800.1; -; Genomic_RNA. DR PIR; A61196; A61196. DR PIR; PQ0246; PQ0246. DR PIR; PQ0251; PQ0251. DR PIR; PQ0252; PQ0252. DR PIR; PQ0254; PQ0254. DR PIR; PS0329; PS0329. DR HSSP; Q8JYS1; 1CWX. DR SMR; Q9DTF0; 902-1026, 1029-1657, 2008-2170, 2420-2981. DR euHCVdb; AB049087; -. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0016021; C:integral to membrane; IEA:InterPro. DR GO; GO:0019028; C:viral capsid; IEA:InterPro. DR GO; GO:0019031; C:viral envelope; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro. DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006915; P:apoptosis; IEA:InterPro. DR GO; GO:0030683; P:evasion by virus of host immune response; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:InterPro. DR GO; GO:0045449; P:regulation of transcription; IEA:InterPro. DR GO; GO:0006410; P:transcription, RNA-dependent; IEA:UniProtKB-KW. DR GO; GO:0019087; P:transformation of host cell by virus; IEA:InterPro. DR GO; GO:0019079; P:viral genome replication; IEA:InterPro. DR InterPro; IPR014001; DEAD-like_N. DR InterPro; IPR011492; DEAD_Flavivir. DR InterPro; IPR001650; DNA/RNA_helicase_C. DR InterPro; IPR002522; HCV_capsid. DR InterPro; IPR002521; HCV_core. DR InterPro; IPR002519; HCV_env. DR InterPro; IPR002531; HCV_NS1. DR InterPro; IPR000745; HCV_NS4a. DR InterPro; IPR001490; HCV_NS4b. DR InterPro; IPR002868; HCV_NS5a. DR InterPro; IPR013193; HCV_NS5a_1b. DR InterPro; IPR014021; Helicase_SF1/SF2_ATP-bd. DR InterPro; IPR002518; Pept_C18_HCV_NS2. DR InterPro; IPR004109; Peptidase_S29. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR InterPro; IPR002166; RNA_pol_HCV. DR InterPro; IPR013192; Znf_HCV_NS5a. DR Pfam; PF07652; Flavi_DEAD; 1. DR Pfam; PF01543; HCV_capsid; 1. DR Pfam; PF01542; HCV_core; 1. DR Pfam; PF01539; HCV_env; 1. DR Pfam; PF01560; HCV_NS1; 1. DR Pfam; PF01538; HCV_NS2; 1. DR Pfam; PF01006; HCV_NS4a; 1. DR Pfam; PF01001; HCV_NS4b; 1. DR Pfam; PF01506; HCV_NS5a; 1. DR Pfam; PF08300; HCV_NS5a_1a; 1. DR Pfam; PF08301; HCV_NS5a_1b; 1. DR Pfam; PF02907; Peptidase_S29; 1. DR Pfam; PF00998; RdRP_3; 1. DR SMART; SM00487; DEXDc; 1. DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1. DR PROSITE; PS51194; HELICASE_CTER; 1. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. PE 4: Predicted; KW ATP-binding; Envelope protein; Helicase; Hydrolase; Membrane; KW Nucleotide-binding; RNA replication; Transmembrane. SQ SEQUENCE 3010 AA; 327156 MW; 7A9C7B1273266FF3 CRC64; MSTNPKPQRK TKRNTNRRPQ DVKFPGGGQI VGGVYLLPRR GPRLGVRATR KTSERSQPRG RRQPIPKARQ PEGRAWAQPG YPWPLYGNEG LGWAGWLLSP RGSRPSWGPT DPRRRSRNLG KVIDTLTCGF ADLMGYIPLV GGPLGGAARA LAHGVRVLED GVNYATGNLP GCSFSIFLLA LLSCLTIPAS AYEVRNVSGV YHVTNDCSNS SIVYEAADMI MHTPGCVPCV RENDCSRCWV ALTPTLAARN SSIPTTTIRR HVDLLVGAAA FCSAMYVGDL CGSIFLVSQL FTFSPRRYWT VQDCNCSIYP GHVSGHRMAW DMMMNWSPTT ALVVSQLLRI PQSVVDMVAG AHWGVLAGLA YYSMVGNWAK VLIVMLLFAG VDGVTHMTGG QVSHNTRSFM SLFTCGPSQK IQLINTNGSW HINRTALNCN DSLQTGFLAA LFYAHNLNSS GCPERMASCR SIDKFAQGWG PITHVVPDTW DQRPYCWHYA PKPCGIVPAS QVCGPVYCFT PSPVVVGTTD RFGVPTYTWG ENETDVLFLN NTRPPQGNWF GCTWMNSTGF TKTCGGPPCN IGGVGNNTLI CPTDCFRKHP EATYTKCGSG PWLTPRCMVD YPYRLWHYPC TVNFTIFKVR MYVGGVEHRL NAACNWTRGE RCDLEDRDRS ELSPLLLSTT EWQVLPCSFT PLPALSTGLI HLHQNIVDVQ YLYGIGSAVV SVVIKWEYVL LLFLLLADAR VCSCLWMMLL IAQAEAALEN LVVLNAASVA GAHGTLSFLV FFCAAWYIKG KLVPGAAYAL YGVWPLLLLL LALPHRAYAM DPEMAASCGG AVFVGLALLT LSPHYKAFLA RLIWWLQYFI TRAEAHLQVW IPPLNVRGGR DAIILLACAV HPELIFDITK ILLAILGPLM VLQAGLTRVP YFVRAQGLIR VCMLVRKVAG GHYFQMALMK LAALTGTYVY DHLTPLRDWA HVGLRDLAVA VEPVVFSDME TKIITWGADT AACGDIISGL PVSARRGREI LLGPADSFRE QGWRLLAPIT AYSQQTRGLL GCIITSLTGR DKNQVEGEVQ VVSTATQSFL ATCVNGVCWT VYHGAGSKTL AGPKGPITQM YTNVDQDLVG WQAPPGARSL TPCTCGSSDL YLVTRHADVI PVRRRGDSRG SLLSPRPVSY LKGSSGGPLL CPSGHAVGIF RAAVCTRGVA KAVDFIPVES METTMRSPVF TDNSSPPAVP QTFQVAHLHA PTGSGKSTKV PAAYAAQGYK VLVLNPSVAA TLSFGAYMSK AHGVDPNIRT GVRTITTGAP ITYSTYGKFL ADGGCSGGAY DIIICDECHS TDSTSILGIG TVLDQAETAG ARLVLLATAT PPGSVTVPHP NIEEVALSNT GEIPFYGKAI PIETIKGGRH LIFCHSKKKC DELAAKLSAL GVNAVAYYRG LDVSVIPTSG NVVVVATDAL MTGYTGDFDS VIDCNTCVTQ TVDFSLDPTF TIETTTVPQD AVSRSQRRGR TGRGRAGIYR FVTPGERPSG MFDSSVLCEC YDAGCAWYEL TPAETSVRLR AYLNTPGLPV CQDHLEFWES VFTGLTHIDA HFLSQTKQAG DNFPYLVAYQ ATVCARAQAP PPSWDQMWKC LIRLKPTLHG PTPLLYRLGA VQNEVTLTHP ITKFIMACMS ADLEVVTSTW VLVGGVLAAL AAYCLTTGSV VIVGRIILSG KPAVIPDREV LYREFDEMEE CASHLPYIEQ GMQLAEQFKQ KALGLLQTAT KQAEAAAPVV ESKWRALETF WAKHMWNFIS GIQYLAGLST LPGNPAIASL MAFTASITSP LTTQHTLLFN ILGGWVAAQL APPSAASAFV GAGIAGAAVG SIGLGKVLVD ILAGYGAGVA GALVAFKVMS GEMPSAEDMV NLLPAILSPG ALVVGVVCAA ILRRHVGPGE GAVQWMNRLI AFASRGNHVS PTHYVPESDA AARVTQILSS LTITQLLKRL HQWINEDCST PCSGSWLRDV WDWICTVLTD FKTWLQSKLL PRLPGVPFFS CQRGYKGVWL GDGVMQTTCP CGAQISGHVK NGSMKIVGPK TCSNTWHGTF PINAYTTGPC TPSPAPNYSR ALWRVAAEEY VEVTRVGEFH YVTGMTTDNV KCPCQVPSPE FFTEVDGVRL HRYAPACKPL LRDEVTFQVG LNQYPVGSQL PCEPEPDVAV LTSMLTDPSH ITAETARRRL ARGSPPSLAS SSASQLSAPS LKATCTTCHD SPDADLIEAN LLWRQEMGGN ITRVESENKV VILDSFDPLR AEEDEREVSV AAEILRKTRK FPPAIPIWAR PDYNPPLLES WKDPDYVPPV VHGCPLPPTK APPIPPPRRK RTVILTESTV SSALAELATK TFGSSGSSAV DSGTATAPPD QPSDDGDTGS DVGSYSSMPP LEGEPGDPDL SDGSWSTVSE EAGEDVVCCS MSYTWTGALI TPCGAEETKL PINALSNSLL RHHNMVYATT SRSASQRQRK VTFDRLQVLD DHYRDVLKEM KAKASTVKAK LLSVEEACKL TPPHSARSKF GYGAKDVRNL SSKAVNHIRS VWKDLLEDTE TPINTTIMAK SEVFCVQPEK GGRKPARLIV FPDLGVRVCE KMALYDVVST LPQAVMGSSY GFQYSPGQRV EFLVNAWKSK KSPMGFAYDT RCFDSTVTES DIRVEESIYQ CCDLAPEARQ VIRSLTERLY IGGPLTNSKG QNCGYRRCRA SGVLTTSCGN TLTCYLKASA ACRAAKLQDC TMLVCGDDLV VICESAGTQE DAANLRVFTE AMTRYSAPPG DPPRPEYDLE LITSCSSNVS VAHDAAGKRV YYLTRDPITP LARAAWETAR HTPVNSWLGN IIMYAPTLWA RMILMTHFFS ILLAQEQLEK ALDCQIYGAV YSIEPLDLPQ IIQRLHGLSA FSLHSYSPGE INRVASCLRK LGVPPLRVWR HRARSVRAKL LSQGGRAATC GKYLFNWAVR TKLKLTPIPA ASQLDLSGWF VAGYSGGDIY HSLSRARPRW FMWCLLLLSV GVGIYLLPNR //