ID Q9DDE0_DANRE Unreviewed; 393 AA. AC Q9DDE0; DT 01-MAR-2001, integrated into UniProtKB/TrEMBL. DT 01-MAR-2001, sequence version 1. DT 29-SEP-2021, entry version 154. DE SubName: Full=Meis homeobox 2a {ECO:0000313|Ensembl:ENSDARP00000034815}; DE SubName: Full=Meis2.1 protein {ECO:0000313|EMBL:CAC19011.1}; DE SubName: Full=Myeloid ecotropic viral integration site 2.1 {ECO:0000313|EMBL:AAH66375.1}; GN Name=meis2b {ECO:0000313|ZFIN:ZDB-GENE-000210-23}; GN Synonyms=meis2.1 {ECO:0000313|EMBL:AAH66375.1}, meis2a GN {ECO:0000313|Ensembl:ENSDARP00000034815, GN ECO:0000313|ZFIN:ZDB-GENE-020122-2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:CAC19011.1}; RN [1] {ECO:0000313|EMBL:CAC19011.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11287203; DOI=10.1016/S0925-4773(01)00299-4; RA Zerucha T., Prince V.E.; RT "Cloning and developmental expression of a zebrafish meis2 homeobox gene."; RL Mech. Dev. 102:247-250(2001). RN [2] {ECO:0000313|EMBL:AAH66375.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Embryo {ECO:0000313|EMBL:AAH66375.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSDARP00000121019} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000121019}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [4] {ECO:0000313|Ensembl:ENSDARP00000034815, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000034815, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [5] {ECO:0000313|Ensembl:ENSDARP00000034815} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000034815}; RG Ensembl; RL Submitted (NOV-2014) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}. CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family. CC {ECO:0000256|ARBA:ARBA00009661}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CU539064; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; FP102948; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC066375; AAH66375.1; -; mRNA. DR EMBL; AJ300652; CAC19011.1; -; mRNA. DR RefSeq; XP_009292852.1; XM_009294577.1. DR STRING; 7955.ENSDARP00000121019; -. DR DNASU; 30066; -. DR Ensembl; ENSDART00000033976; ENSDARP00000034815; ENSDARG00000077840. DR Ensembl; ENSDART00000144970; ENSDARP00000121019; ENSDARG00000077840. DR GeneID; 30066; -. DR CTD; 30066; -. DR ZFIN; ZDB-GENE-020122-2; meis2a. DR ZFIN; ZDB-GENE-000210-23; meis2b. DR eggNOG; KOG0773; Eukaryota. DR GeneTree; ENSGT00940000155643; -. DR HOGENOM; CLU_023139_1_1_1; -. DR OMA; MDDAHST; -. DR PhylomeDB; Q9DDE0; -. DR TreeFam; TF318093; -. DR Proteomes; UP000000437; Chromosome 20. DR Bgee; ENSDARG00000077840; Expressed in retina and 46 other tissues. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central. DR GO; GO:0007420; P:brain development; IBA:GO_Central. DR GO; GO:0003209; P:cardiac atrium morphogenesis; IMP:ZFIN. DR GO; GO:0009880; P:embryonic pattern specification; IBA:GO_Central. DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:ZFIN. DR GO; GO:0001654; P:eye development; IBA:GO_Central. DR GO; GO:0007507; P:heart development; IMP:ZFIN. DR GO; GO:0001947; P:heart looping; IMP:ZFIN. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd00086; homeodomain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR008422; Homeobox_KN_domain. DR InterPro; IPR032453; PKNOX/Meis_N. DR Pfam; PF05920; Homeobox_KN; 1. DR Pfam; PF16493; Meis_PKNOX_N; 1. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 1: Evidence at protein level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q9DDE0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. FT DOMAIN 273..336 FT /note="Homeobox" FT /evidence="ECO:0000259|PROSITE:PS50071" FT DNA_BIND 275..337 FT /note="Homeobox" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108" FT REGION 202..281 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 230..256 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 393 AA; 43043 MW; F8ABE55EAF8190E9 CRC64; MLMAQRYEDL AHYGGGMDGV GVPTSMYGDP HAPRPLPQVH HLNHGPPPHA NQHYGAHAPH SIMPSSMGSA VNDALKRDKD QIYGHPLFPL LALVFEKCEL ATCTPREPGV AGGDVCSSDS FNEDIAVFAK QIRAEKPLFS SNPELDNLMI QSIQVLRFHL LELEKVHELC DNFCHRYISC LKGKMPIDLV IDERDGCKSD FDDLSGSSTN LADHNPASWR DMDDAHSTPS VGTPGPSSGG HASQSGDNSS ELGDGLDNSL ASPGTGDEDD QDKKRQKKRG IFPKVATNIM RAWLFQHLTH PYPSEEQKKQ LAQDTGLTIL QVNNWFINAR RRIVQPMIDQ SNRAVSQGTA YSPDGQPMGG FVLDGQQHMG LRPGGPMGGM GMNMGMDGQW HYM //